Sökning: WFRF:(Heid Iris M.) > The association of ...
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000 | 05085naa a2200817 4500 | |
001 | oai:lup.lub.lu.se:0fb60118-e55e-415e-8d89-3475b8618c02 | |
003 | SwePub | |
008 | 160401s2007 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:115087682 | |
024 | 7 | a https://lup.lub.lu.se/record/6632612 URI |
024 | 7 | a https://doi.org/10.1371/journal.pgen.00300612 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1150876822 URI |
040 | a (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Lyon, Helen N.4 aut |
245 | 1 0 | a The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts |
264 | c 2007-04-27 | |
264 | 1 | b Public Library of Science (PLoS),c 2007 |
520 | a A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) by Herbert and colleagues. The association between increased BMI and homozygosity for the minor allele was first observed in data from a genome-wide association scan of 86,604 SNPs in 923 related individuals from the Framingham Heart Study offspring cohort. The association was reproduced in four additional cohorts, but was not seen in a fifth cohort. To further assess the general reproducibility of this association, we genotyped rs7566605 in nine large cohorts from eight populations across multiple ethnicities (total n = 16,969). We tested this variant for association with BMI in each sample under a recessive model using family-based, population-based, and case-control designs. We observed a significant (p < 0.05) association in five cohorts but saw no association in three other cohorts. There was variability in the strength of association evidence across examination cycles in longitudinal data from unrelated individuals in the Framingham Heart Study Offspring cohort. A combined analysis revealed significant independent validation of this association in both unrelated (p = 0.046) and family-based (p = 0.004) samples. The estimated risk conferred by this allele is small, and could easily be masked by small sample size, population stratification, or other confounders. These validation studies suggest that the original association is less likely to be spurious, but the failure to observe an association in every data set suggests that the effect of SNP rs7566605 on BMI may be heterogeneous across population samples. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
700 | 1 | a Emilsson, Valur4 aut |
700 | 1 | a Hinney, Anke4 aut |
700 | 1 | a Heid, Iris M.4 aut |
700 | 1 | a Lasky-Su, Jessica4 aut |
700 | 1 | a Zhu, Xiaofeng4 aut |
700 | 1 | a Thorleifsson, Gudmar4 aut |
700 | 1 | a Gunnarsdottir, Steinunn4 aut |
700 | 1 | a Walters, G. Bragi4 aut |
700 | 1 | a Thorsteinsdottir, Unnur4 aut |
700 | 1 | a Kong, Augustine4 aut |
700 | 1 | a Gulcher, Jeffrey4 aut |
700 | 1 | a Nguyen, Thuy Trang4 aut |
700 | 1 | a Scherag, Andre4 aut |
700 | 1 | a Pfeufer, Arne4 aut |
700 | 1 | a Meitinger, Thomas4 aut |
700 | 1 | a Broenner, Guenter4 aut |
700 | 1 | a Rief, Winfried4 aut |
700 | 1 | a Soto-Quiros, Manuel E.4 aut |
700 | 1 | a Avila, Lydiana4 aut |
700 | 1 | a Klanderman, Barbara4 aut |
700 | 1 | a Raby, Benjamin A.4 aut |
700 | 1 | a Silverman, Edwin K.4 aut |
700 | 1 | a Weiss, Scott T.4 aut |
700 | 1 | a Laird, Nan4 aut |
700 | 1 | a Ding, Xiao4 aut |
700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr |
700 | 1 | a Tuomi, Tiinamaija4 aut |
700 | 1 | a Isomaa, Bo4 aut |
700 | 1 | a Bengtsson, Kristina4 aut |
700 | 1 | a Butler, Johannah L.4 aut |
700 | 1 | a Cooper, Richard S.4 aut |
700 | 1 | a Fox, Caroline S.4 aut |
700 | 1 | a O'Donnell, Christopher J.4 aut |
700 | 1 | a Vollmert, Caren4 aut |
700 | 1 | a Celedon, Juan C.4 aut |
700 | 1 | a Wichmann, H. Erich4 aut |
700 | 1 | a Hebebrand, Johannes4 aut |
700 | 1 | a Stefansson, Kari4 aut |
700 | 1 | a Lange, Christophu Karolinska Institutet4 aut |
700 | 1 | a Hirschhorn, Joel N.4 aut |
710 | 2 | a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t PLoS Geneticsd : Public Library of Science (PLoS)g 3:4q 3:4x 1553-7404 |
856 | 4 | u http://dx.doi.org/10.1371/journal.pgen.0030061x freey FULLTEXT |
856 | 4 | u https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0030061&type=printable |
856 | 4 8 | u https://lup.lub.lu.se/record/663261 |
856 | 4 8 | u https://doi.org/10.1371/journal.pgen.0030061 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:115087682 |
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