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Tumour-specific HMG...
Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer
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Brennan, Donal J. (author)
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- Brändstedt, Jenny (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Patologi, Malmö,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Pathology, Malmö,Lund University Research Groups
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Rexhepaj, Elton (author)
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Foley, Michael (author)
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- Pontén, Fredrik (author)
- Uppsala universitet,Institutionen för genetik och patologi,Fredrik Pontén
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- Uhlén, Mathias (author)
- KTH,Proteomik
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Gallagher, William M. (author)
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O'Connor, Darran P. (author)
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O'Herlihy, Colm (author)
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- Jirström, Karin (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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(creator_code:org_t)
- 2010-04-01
- 2010
- English.
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In: BMC Cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 10, s. 125-
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Abstract
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- Background: Our group previously reported that tumour-specific expression of the rate-limiting enzyme in the mevalonate pathway, 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMG-CoAR) is associated with more favourable tumour parameters and a good prognosis in breast cancer. In the present study, the prognostic value of HMG-CoAR expression was examined in tumours from a cohort of patients with primary epithelial ovarian cancer. Methods: HMG-CoAR expression was assessed using immunohistochemistry (IHC) on tissue microarrays (TMA) consisting of 76 ovarian cancer cases, analysed using automated algorithms to develop a quantitative scoring model. Kaplan Meier analysis and Cox proportional hazards modelling were used to estimate the risk of recurrence free survival (RFS). Results: Seventy-two tumours were suitable for analysis. Cytoplasmic HMG-CoAR expression was present in 65% (n = 46) of tumours. No relationship was seen between HMG-CoAR and age, histological subtype, grade, disease stage, estrogen receptor or Ki-67 status. Patients with tumours expressing HMG-CoAR had a significantly prolonged RFS (p = 0.012). Multivariate Cox regression analysis revealed that HMG-CoAR expression was an independent predictor of improved RFS (RR = 0.49, 95% CI (0.25-0.93); p = 0.03) when adjusted for established prognostic factors such as residual disease, tumour stage and grade. Conclusion: HMG-CoAR expression is an independent predictor of prolonged RFS in primary ovarian cancer. As HMG-CoAR inhibitors, also known as statins, have demonstrated anti-neoplastic effects in vitro, further studies are required to evaluate HMG-CoAR expression as a surrogate marker of response to statin treatment, especially in conjunction with current chemotherapeutic regimens.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- REDUCTASE EXPRESSION
- PERILLYL ALCOHOL
- CELL-CYCLE
- STATIN USE
- FOLLOW-UP
- RISK
- MEVALONATE
- INHIBITION
- LOVASTATIN
- MEDICINE
- MEDICIN
- Biology
- Biologi
- Obstetrics and gynaecology
- Pathology
- Pathology
- Obstetrik och gynekologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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BMC Cancer
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Brennan, Donal J ...
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Brändstedt, Jenn ...
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Rexhepaj, Elton
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Foley, Michael
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Pontén, Fredrik
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Uhlén, Mathias
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show more...
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Gallagher, Willi ...
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O'Connor, Darran ...
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O'Herlihy, Colm
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Jirström, Karin
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NATURAL SCIENCES
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BMC Cancer
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Royal Institute of Technology
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Lund University
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Uppsala University