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Association between...
Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries : a cross-sectional analysis in the EPIC-InterAct study
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- Zheng, Ju-Sheng (författare)
- University of Cambridge
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- Sharp, Stephen J. (författare)
- University of Cambridge
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- Imamura, Fumiaki (författare)
- University of Cambridge
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- Koulman, Albert (författare)
- MRC Human Nutrition Research,NIHR Cambridge Biomedical Research Centre
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- Schulze, Matthias B. (författare)
- German Institute of Human Nutrition
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- Ye, Zheng (författare)
- University of Cambridge
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- Griffin, Jules (författare)
- University of Cambridge
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- Guevara, Marcela (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)
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- María Huerta, José (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council
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- Kröger, Janine (författare)
- German Institute of Human Nutrition
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- Sluijs, Ivonne (författare)
- University Medical Center Utrecht
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- Agudo, Antonio (författare)
- Bellvitge University Hospital-IDIBELL
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- Barricarte, Aurelio (författare)
- Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)
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- Boeing, Heiner (författare)
- German Institute of Human Nutrition
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- Colorado-Yohar, Sandra (författare)
- University of Antioquia
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- Dow, Courtney (författare)
- Centre for Research in Epidemiology and Population Health (CESP),Stabilite genetique et oncogenese,University of Paris-Saclay
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- Dorronsoro, Miren (författare)
- Public Health Division of Gipuzkoa
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- Dinesen, Pia T. (författare)
- Aalborg University
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- Fagherazzi, Guy (författare)
- University of Paris-Saclay,Stabilite genetique et oncogenese,Centre for Research in Epidemiology and Population Health (CESP)
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- Franks, Paul W. (författare)
- Umeå University,Lunds universitet,Umeå universitet,Medicin,Lund University, Malmö, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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- Feskens, Edith J. M. (författare)
- Wageningen University
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- Kühn, Tilman (författare)
- German Cancer Research Centre
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- Katzke, Verena Andrea (författare)
- German Cancer Research Centre
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- Key, Timothy J. (författare)
- University of Oxford
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- Khaw, Kay-Tee (författare)
- University of Cambridge
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- de Magistris, Maria Santucci (författare)
- University of Naples Federico II
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- Romana Mancini, Francesca (författare)
- University of Paris-Saclay,Stabilite genetique et oncogenese,Centre for Research in Epidemiology and Population Health (CESP)
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- Molina-Portillo, Elena (författare)
- CIBER Epidemiology and Public Health (CIBERESP),University of Granada
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- Nilsson, Peter M. (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Olsen, Anja (författare)
- Danish Cancer Society
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- Overvad, Kim (författare)
- Aarhus University,Aalborg University
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- Palli, Domenico (författare)
- Cancer Research and Prevention Institute (ISPO)
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- Ramón Quirós, Jose (författare)
- Public Health Directorate
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- Rolandsson, Olov (författare)
- Umeå University,Umeå universitet,Allmänmedicin
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- Ricceri, Fulvio (författare)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Spijkerman, Annemieke M. W. (författare)
- National Institute for Public Health and the Environment (RIVM)
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- Slimani, Nadia (författare)
- International Agency for Research on Cancer, World Health Organization
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- Tagliabue, Giovanna (författare)
- Istituto Nazionale dei Tumori
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- Tjonneland, Anne (författare)
- Danish Cancer Society
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- Tumino, Rosario (författare)
- Civic and M.P Arezzo Hospital
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- van der Schouw, Yvonne T. (författare)
- University Medical Center Utrecht
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- Langenberg, Claudia (författare)
- University of Cambridge
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- Riboli, Elio (författare)
- Imperial College London
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- Forouhi, Nita G. (författare)
- University of Cambridge
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- Wareham, Nicholas J. (författare)
- University of Cambridge
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(creator_code:org_t)
- 2017-11-17
- 2017
- Engelska.
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Ingår i: BMC Medicine. - : BioMed Central. - 1741-7015. ; 15
- Relaterad länk:
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https://doi.org/10.1...
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visa fler...
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https://umu.diva-por... (primary) (Raw object)
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https://bmcmedicine....
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background: Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic diseases, but evidence about associations of SFAs with metabolic markers of different pathogenic pathways is limited. We aimed to examine the associations between plasma phospholipid SFAs and the metabolic markers of lipid, hepatic, glycaemic and inflammation pathways. Methods: We measured nine individual plasma phospholipid SFAs and derived three SFA groups (odd-chain: C15:0 + C17:0, even-chain: C14:0 + C16:0 + C18:0, and very-long-chain: C20:0 + C22:0 + C23:0 + C24:0) in individuals from the subcohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study across eight European countries. Using linear regression in 15,919 subcohort members, adjusted for potential confounders and corrected for multiple testing, we examined cross-sectional associations of SFAs with 13 metabolic markers. Multiplicative interactions of the three SFA groups with pre-specified factors, including body mass index (BMI) and alcohol consumption, were tested. Results: Higher levels of odd-chain SFA group were associated with lower levels of major lipids (total cholesterol (TC), triglycerides, apolipoprotein A-1 (ApoA1), apolipoprotein B (ApoB)) and hepatic markers (alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transferase (GGT)). Higher even-chain SFA group levels were associated with higher levels of low-density lipoprotein cholesterol (LDL-C), TC/high-density lipoprotein cholesterol (HDL-C) ratio, triglycerides, ApoB, ApoB/A1 ratio, ALT, AST, GGT and CRP, and lower levels of HDL-C and ApoA1. Very-long-chain SFA group levels showed inverse associations with triglycerides, ApoA1 and GGT, and positive associations with TC, LDL-C, TC/HDL-C, ApoB and ApoB/A1. Associations were generally stronger at higher levels of BMI or alcohol consumption. Conclusions: Subtypes of SFAs are associated in a differential way with metabolic markers of lipid metabolism, liver function and chronic inflammation, suggesting that odd-chain SFAs are associated with lower metabolic risk and even-chain SFAs with adverse metabolic risk, whereas mixed findings were obtained for very-long-chain SFAs. The clinical and biochemical implications of these findings may vary by adiposity and alcohol intake.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Saturated fatty acids
- Odd-chain
- Even-chain
- Very-long-chain
- Metabolic markers
- Lipids
- Hepatic
- ycaemic
- Inflammation
- Even-chain
- Glycaemic
- Hepatic
- Inflammation
- Lipids
- Metabolic markers
- Odd-chain
- Saturated fatty acids
- Very-long-chain
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Zheng, Ju-Sheng
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Sharp, Stephen J ...
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Imamura, Fumiaki
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Koulman, Albert
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Schulze, Matthia ...
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Ye, Zheng
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visa fler...
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Griffin, Jules
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Guevara, Marcela
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María Huerta, Jo ...
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Kröger, Janine
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Sluijs, Ivonne
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Agudo, Antonio
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Barricarte, Aure ...
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Boeing, Heiner
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Colorado-Yohar, ...
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Dow, Courtney
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Dorronsoro, Mire ...
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Dinesen, Pia T.
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Fagherazzi, Guy
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Franks, Paul W.
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Feskens, Edith J ...
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Kühn, Tilman
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Katzke, Verena A ...
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Key, Timothy J.
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Khaw, Kay-Tee
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de Magistris, Ma ...
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Romana Mancini, ...
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Molina-Portillo, ...
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Nilsson, Peter M ...
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Olsen, Anja
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Overvad, Kim
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Palli, Domenico
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Ramón Quirós, Jo ...
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Rolandsson, Olov
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Ricceri, Fulvio
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Spijkerman, Anne ...
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Slimani, Nadia
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Tagliabue, Giova ...
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Tjonneland, Anne
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Tumino, Rosario
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van der Schouw, ...
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Langenberg, Clau ...
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Riboli, Elio
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Forouhi, Nita G.
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Wareham, Nichola ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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BMC Medicine
- Av lärosätet
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Umeå universitet
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Lunds universitet