Bravo capsule system optimizes intragastric pH monitoring over prolonged time: Effects of ghrelin on gastric acid and hormone secretion in the rat

Bravo capsule system optimizes intragastric pH monitoring over prolonged time : Effects of ghrelin on gastric acid and hormone secretion in the rat

Rudholm, Tobias (author): Department of Medicine Solna, Karolinska Institutet

Hellstrom, Per M., 1954- (author): Department of Medicine Solna, Karolinska Institutet,Gastro/Hellström

Theodorsson, Elvar (author): Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Klinisk kemi,Department of Neurochemistry, Linköping University Hospital

Campbell, Colin Allan (author): Neurology and GI CEDD, GlaxoSmithKline, Harlow, UK, Essex CM19 5AW, United Kingdom

McLean, Peter Geoffrey (author): Neurology and GI CEDD, GlaxoSmithKline, Harlow, UK, Essex CM19 5AW, United Kingdom

(creator_code:org_t)

Baishideng Publishing Group Inc. 2008
2008
English.
In: World Journal of Gastroenterology. - : Baishideng Publishing Group Inc.. - 1007-9327 .- 2219-2840. ; 14:40, s. 6180-6187

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Abstract Subject headings

Aim: To evaluate measurements of intragastric pH with the Bravo capsule system over a prolonged time. Methods: A Bravo capsule was placed inside the rat gastric body and pH was studied for periods up to five consecutive. days. For comparison, a gastric fistula model was used. Effects of ghrelin and esomeprazole, with or without pentagastrin, on gastric pH were studied. In addition, effects of esomeprazole on plasma ghrelin, gastrin and somatostatin were analyzed. Results: All rats recovered after surgery. The average 24-h pH during free feeding was 2.3 +/- 0.1 (n = 20) with a variation of 18% +/- 6% over 5 d. Ghrelin, 2400 pmol/kg, t.i.d. increased pH from 1.7 +/- 0.1 to 3.1 +/- 0.3 (P < 0.01) as recorded with the Bravo system. After esomeprazole (1 mg/kg, 3 mg/kg and 5 mg/kg) there was a dose-dependent pH increase of maximally 3.4 +/- 0.1, with day-to-day variation over the entire period of 8% +/- 3%. The fistula and pH studies generated similar results. Acid inhibition with esomeprazole increased plasma ghrelin from 10 +/- 2 pmol/L to 65 +/- 26 pmol/L (P < 0.001), and somatostatin from 10 +/- 2 pmol/L to 67 +/- 18 pmol/L (P < 0.001). Conclusion: pH measurements with the Bravo capsule are reliable, and comparable to those of the gastric fistula model. The Bravo system optimizes accurate intragastric pH monitoring over prolonged periods and allows both short- and long-term evaluation of effects of drugs and hormones.

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)

By the author/editor: Rudholm, Tobias; Hellstrom, Per M ...; Theodorsson, Elv ...; Campbell, Colin ...; McLean, Peter Ge ...; Naslund, Erik

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Gastroenterology ...

By the university: Linköping University; Uppsala University; Red Cross University College; Högskolan Dalarna; Karolinska Institutet

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