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Sökning: ((WFRF:(Arslan Alan A.)) pers:(Albanes Demetrius)) > (2015-2019) > Circulating cotinin...

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FältnamnIndikatorerMetadata
00007092naa a2201081 4500
001oai:DiVA.org:umu-156619
003SwePub
008190220s2018 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:1a1191da-5a07-470b-b6e0-32cf5c341afa
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1566192 URI
0247 a https://doi.org/10.1093/ije/dyy1002 DOI
0247 a https://lup.lub.lu.se/record/1a1191da-5a07-470b-b6e0-32cf5c341afa2 URI
040 a (SwePub)umud (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Larose, Tricia L.u Norwegian University of Science and Technology,International Agency for Research on Cancer, World Health Organization4 aut
2451 0a Circulating cotinine concentrations and lung cancer risk in the Lung Cancer Cohort Consortium (LC3)
264 c 2018-06-12
264 1b Oxford University Press,c 2018
338 a print2 rdacarrier
520 a Background: Self-reported smoking is the principal measure used to assess lung cancer risk in epidemiological studies. We evaluated if circulating cotinine—a nicotine metabolite and biomarker of recent tobacco exposure—provides additional information on lung cancer risk.Methods: The study was conducted in the Lung Cancer Cohort Consortium (LC3) involving 20 prospective cohort studies. Pre-diagnostic serum cotinine concentrations were measured in one laboratory on 5364 lung cancer cases and 5364 individually matched controls. We used conditional logistic regression to evaluate the association between circulating cotinine and lung cancer, and assessed if cotinine provided additional risk-discriminative information compared with self-reported smoking (smoking status, smoking intensity, smoking duration), using receiver-operating characteristic (ROC) curve analysis.Results: We observed a strong positive association between cotinine and lung cancer risk for current smokers [odds ratio (OR ) per 500 nmol/L increase in cotinine (OR500): 1.39, 95% confidence interval (CI): 1.32–1.47]. Cotinine concentrations consistent with active smoking (≥115 nmol/L) were common in former smokers (cases: 14.6%; controls: 9.2%) and rare in never smokers (cases: 2.7%; controls: 0.8%). Former and never smokers with cotinine concentrations indicative of active smoking (≥115 nmol/L) also showed increased lung cancer risk. For current smokers, the risk-discriminative performance of cotinine combined with self-reported smoking (AUCintegrated: 0.69, 95% CI: 0.68–0.71) yielded a small improvement over self-reported smoking alone (AUCsmoke: 0.66, 95% CI: 0.64–0.68) (P = 1.5x10–9).Conclusions: Circulating cotinine concentrations are consistently associated with lung cancer risk for current smokers and provide additional risk-discriminative information compared with self-report smoking alone.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Cotinine
653 a biomarker
653 a lung cancer
653 a consortium
653 a case-control
653 a prospective
7001 a Guida, Florence4 aut
7001 a Fanidi, Anouar4 aut
7001 a Langhammer, Arnulf4 aut
7001 a Kveem, Kristian4 aut
7001 a Stevens, Victoria L.4 aut
7001 a Jacobs, Eric J.4 aut
7001 a Smith-Warner, Stephanie A.4 aut
7001 a Giovannucci, Edward4 aut
7001 a Albanes, Demetrius4 aut
7001 a Weinstein, Stephanie J.4 aut
7001 a Freedman, Neal D.4 aut
7001 a Prentice, Ross4 aut
7001 a Pettinger, Mary4 aut
7001 a Thomson, Cynthia A.4 aut
7001 a Cai, Qiuyin4 aut
7001 a Wu, Jie4 aut
7001 a Blot, William J.4 aut
7001 a Arslan, Alan A.4 aut
7001 a Zeleniuch-Jacquotte, Anne4 aut
7001 a Le Marchand, Loic4 aut
7001 a Wilkens, Lynne R.4 aut
7001 a Haiman, Christopher A.4 aut
7001 a Zhang, Xuehong4 aut
7001 a Stampfer, Meir J.4 aut
7001 a Hodge, Allison M.4 aut
7001 a Giles, Graham G.4 aut
7001 a Severi, Gianluca4 aut
7001 a Johansson, Mikaelu Umeå universitet,Onkologi4 aut0 (Swepub:umu)mijo0025
7001 a Grankvist, Kjellu Umeå universitet,Klinisk kemi4 aut0 (Swepub:umu)kjgr0002
7001 a Wang, Renwei4 aut
7001 a Yuan, Jian-Min4 aut
7001 a Gao, Yu-Tang4 aut
7001 a Koh, Woon-Puay4 aut
7001 a Shu, Xiao-Ou4 aut
7001 a Zheng, Wei4 aut
7001 a Xiang, Yong-Bing4 aut
7001 a Li, Honglan4 aut
7001 a Lan, Qing4 aut
7001 a Visvanathan, Kala4 aut
7001 a Bolton, Judith Hoffman4 aut
7001 a Ueland, Per Magne4 aut
7001 a Midttun, Oivind4 aut
7001 a Caporaso, Neil4 aut
7001 a Purdue, Mark4 aut
7001 a Sesso, Howard D.4 aut
7001 a Buring, Julie E.4 aut
7001 a Lee, I-Min4 aut
7001 a Gaziano, J. Michael4 aut
7001 a Manjer, Jonasu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)smi-jma
7001 a Brunnström, Hansu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups,Regional Laboratories Region Skåne4 aut0 (Swepub:lu)med-hsb
7001 a Brennan, Paul4 aut
7001 a Johansson, Mattiasu International Agency for Research on Cancer, World Health Organization4 aut
7102 a Norwegian University of Science and Technologyb International Agency for Research on Cancer, World Health Organization4 org
7102 a Lung Cancer Cohort Consortium
7730 t International Journal of Epidemiologyd : Oxford University Pressg 47:6, s. 1760-1771q 47:6<1760-1771x 0300-5771x 1464-3685
8564 u https://academic.oup.com/ije/article-pdf/47/6/1760/27015961/dyy100.pdf
8564 u http://dx.doi.org/10.1093/ije/dyy100y FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-156619
8564 8u https://doi.org/10.1093/ije/dyy100
8564 8u https://lup.lub.lu.se/record/1a1191da-5a07-470b-b6e0-32cf5c341afa

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