Search: (L773:1552 5279 OR L773:1552 5260) lar1:(lu) pers:(Hansson Oskar)
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The impact of prean...
The impact of preanalytical variables on measuring cerebrospinal fluid biomarkers for Alzheimer's disease diagnosis : A review
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- Hansson, Oskar (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Mikulskis, Alvydas (author)
- Biogen, Inc.
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- Fagan, Anne M. (author)
- Washington University in St. Louis
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- Teunissen, Charlotte (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Zetterberg, Henrik (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,University College London,Sahlgrenska University Hospital,UK Dementia Research Institute,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Vanderstichele, Hugo (author)
- ADx NeuroSciences
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- Molinuevo, Jose Luis (author)
- Pasqual Maragall Foundation for Research on Alzheimer
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- Shaw, Leslie M. (author)
- University of Pennsylvania
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- Vandijck, Manu (author)
- Fujirebio Europe N.V.
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- Verbeek, Marcel M. (author)
- Radboud University Nijmegen
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- Savage, Mary (author)
- Merck Sharp And Dohme Corp., US
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- Mattsson, Niklas (author)
- Lund University,Lunds universitet,Brain Injury After Cardiac Arrest,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Lewczuk, Piotr (author)
- University Hospital Erlangen,Medical University of Bialystok,Friedrich-Alexander University Erlangen-Nürnberg
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- Batrla, Richard (author)
- Roche Diagnostics International
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- Rutz, Sandra (author)
- Roche Diagnostics, Germany
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- Dean, Robert A. (author)
- Indiana University
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- Blennow, Kaj (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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(creator_code:org_t)
- 2018-06-22
- 2018
- English 21 s.
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In: Alzheimer's and Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 14:10, s. 1313-1333
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Abstract
Subject headings
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- Introduction: Cerebrospinal fluid (CSF) biomarkers have the potential to improve the diagnostic accuracy of Alzheimer's disease, yet there is a lack of harmonized preanalytical CSF handling protocols. Methods: This systematic review summarizes the current literature on the influence of preanalytical variables on CSF biomarker concentration. We evaluated the evidence for three core CSF biomarkers: β-amyloid 42, total tau, and phosphorylated tau. Results: The clinically important variables with the largest amount of conflicting data included the temperature at which samples are stored, the time nonfrozen samples can be stored, and possible effects of additives such as detergents, blood contamination, and centrifugation. Conversely, we discovered that there is consensus that tube material has a significant effect. Discussion: A unified CSF handling protocol is recommended to reduce preanalytical variability and facilitate comparison of CSF biomarkers across studies and laboratories. In future, experiments should use a gold standard with fresh CSF collected in low binding tubes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease diagnosis
- Biomarkers
- Cerebrospinal fluid
- Phosphorylated tau
- Preanalytical variables
- Total tau
- β-Amyloid 42
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- By the author/editor
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Hansson, Oskar
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Mikulskis, Alvyd ...
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Fagan, Anne M.
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Teunissen, Charl ...
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Zetterberg, Henr ...
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Vanderstichele, ...
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show more...
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Molinuevo, Jose ...
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Shaw, Leslie M.
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Vandijck, Manu
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Verbeek, Marcel ...
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Savage, Mary
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Mattsson, Niklas
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Lewczuk, Piotr
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Batrla, Richard
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Rutz, Sandra
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Dean, Robert A.
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Blennow, Kaj
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer's and ...
- By the university
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Lund University
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University of Gothenburg