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Search: (L773:1552 5279 OR L773:1552 5260) lar1:(lu) pers:(Hansson Oskar) > (2015-2019) > The impact of prean...

  • Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital (author)

The impact of preanalytical variables on measuring cerebrospinal fluid biomarkers for Alzheimer's disease diagnosis : A review

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-06-22
  • Wiley,2018
  • 21 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:e34b682d-f621-46a7-8948-f65fd44a3858
  • https://lup.lub.lu.se/record/e34b682d-f621-46a7-8948-f65fd44a3858URI
  • https://doi.org/10.1016/j.jalz.2018.05.008DOI
  • https://gup.ub.gu.se/publication/269616URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:for swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Introduction: Cerebrospinal fluid (CSF) biomarkers have the potential to improve the diagnostic accuracy of Alzheimer's disease, yet there is a lack of harmonized preanalytical CSF handling protocols. Methods: This systematic review summarizes the current literature on the influence of preanalytical variables on CSF biomarker concentration. We evaluated the evidence for three core CSF biomarkers: β-amyloid 42, total tau, and phosphorylated tau. Results: The clinically important variables with the largest amount of conflicting data included the temperature at which samples are stored, the time nonfrozen samples can be stored, and possible effects of additives such as detergents, blood contamination, and centrifugation. Conversely, we discovered that there is consensus that tube material has a significant effect. Discussion: A unified CSF handling protocol is recommended to reduce preanalytical variability and facilitate comparison of CSF biomarkers across studies and laboratories. In future, experiments should use a gold standard with fresh CSF collected in low binding tubes.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Mikulskis, AlvydasBiogen, Inc. (author)
  • Fagan, Anne M.Washington University in St. Louis (author)
  • Teunissen, CharlotteAmsterdam UMC - Vrije Universiteit Amsterdam (author)
  • Zetterberg, HenrikGothenburg University,Göteborgs universitet,University of Gothenburg,University College London,Sahlgrenska University Hospital,UK Dementia Research Institute,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (author)
  • Vanderstichele, HugoADx NeuroSciences (author)
  • Molinuevo, Jose LuisPasqual Maragall Foundation for Research on Alzheimer (author)
  • Shaw, Leslie M.University of Pennsylvania (author)
  • Vandijck, ManuFujirebio Europe N.V. (author)
  • Verbeek, Marcel M.Radboud University Nijmegen (author)
  • Savage, MaryMerck Sharp And Dohme Corp., US (author)
  • Mattsson, NiklasLund University,Lunds universitet,Brain Injury After Cardiac Arrest,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-nmn (author)
  • Lewczuk, PiotrUniversity Hospital Erlangen,Medical University of Bialystok,Friedrich-Alexander University Erlangen-Nürnberg (author)
  • Batrla, RichardRoche Diagnostics International (author)
  • Rutz, SandraRoche Diagnostics, Germany (author)
  • Dean, Robert A.Indiana University (author)
  • Blennow, KajGothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
  • Klinisk minnesforskningForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Alzheimer's and Dementia: Wiley14:10, s. 1313-13331552-52601552-5279

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