Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma

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Cerhan, James R. (author)

Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma

Article/chapterEnglish2014

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2014-09-28
Springer Science and Business Media LLC,2014
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LIBRIS-ID:oai:DiVA.org:uu-238436
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-238436URI
https://doi.org/10.1038/ng.3105DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:130053526URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 x 10(-21)), rs2523607 at 6p21.33 (HLA-B; P = 2.40 x 10(-10)), rs79480871 at 2p23.3 (NCOA1; P = 4.23 x 10(-8)) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 x 10(-13) and 3.63 x 10(-11), respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.

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Berndt, Sonja I. (author)
Vijai, Joseph (author)
Ghesquieres, Herve (author)
McKay, James (author)
Wang, Sophia S. (author)
Wang, Zhaoming (author)
Yeager, Meredith (author)
Conde, Lucia (author)
de Bakker, Paul I. W. (author)
Nieters, Alexandra (author)
Cox, David (author)
Burdett, Laurie (author)
Monnereau, Alain (author)
Flowers, Christopher R. (author)
De Roos, Anneclaire J. (author)
Brooks-Wilson, Angela R. (author)
Lan, Qing (author)
Severi, Gianluca (author)
Melbye, Mads (author)
Gu, Jian (author)
Jackson, Rebecca D. (author)
Kane, EleanorKarolinska Institutet (author)
Teras, Lauren R. (author)
Purdue, Mark P. (author)
Vajdic, Claire M. (author)
Spinelli, John J. (author)
Giles, Graham G. (author)
Albanes, Demetrius (author)
Kelly, Rachel S. (author)
Zucca, Mariagrazia (author)
Bertrand, Kimberly A. (author)
Zeleniuch-Jacquotte, Anne (author)
Lawrence, Charles (author)
Hutchinson, Amy (author)
Zhi, Degui (author)
Habermann, Thomas M. (author)
Link, Brian K. (author)
Novak, Anne J. (author)
Dogan, Ahmet (author)
Asmann, Yan W. (author)
Liebow, Mark (author)
Thompson, Carrie A. (author)
Ansell, Stephen M. (author)
Witzig, Thomas E. (author)
Weiner, George J. (author)
Veron, Amelie S. (author)
Zelenika, Diana (author)
Tilly, Herve (author)
Haioun, Corinne (author)
Molina, Thierry Jo (author)
Hjalgrim, HenrikKarolinska Institutet (author)
Glimelius, BengtUppsala universitet,Enheten för onkologi(Swepub:uu)bengglim (author)
Adami, Hans-Olov (author)
Bracci, Paige M. (author)
Riby, Jacques (author)
Smith, Martyn T. (author)
Holly, Elizabeth A. (author)
Cozen, Wendy (author)
Hartge, Patricia (author)
Morton, Lindsay M. (author)
Severson, Richard K. (author)
Tinker, Lesley F. (author)
North, Kari E. (author)
Becker, Nikolaus (author)
Benavente, Yolanda (author)
Boffetta, Paolo (author)
Brennan, Paul (author)
Foretova, Lenka (author)
Maynadie, Marc (author)
Staines, Anthony (author)
Lightfoot, Tracy (author)
Crouch, Simon (author)
Smith, Alex (author)
Roman, Eve (author)
Diver, W. Ryan (author)
Offit, Kenneth (author)
Zelenetz, Andrew (author)
Klein, Robert J. (author)
Villano, Danylo J. (author)
Zheng, Tongzhang (author)
Zhang, Yawei (author)
Holford, Theodore R. (author)
Kricker, Anne (author)
Turner, Jenny (author)
Southey, Melissa C. (author)
Clavel, Jacqueline (author)
Virtamo, Jarmo (author)
Weinstein, Stephanie (author)
Riboli, Elio (author)
Vineis, Paolo (author)
Kaaks, Rudolph (author)
Trichopoulos, Dimitrios (author)
Vermeulen, Roel C. H. (author)
Boeing, Heiner (author)
Tjonneland, Anne (author)
Angelucci, Emanuele (author)
Di Lollo, Simonetta (author)
Rais, Marco (author)
Birmann, Brenda M. (author)
Laden, Francine (author)
Giovannucci, Edward (author)
Kraft, Peter (author)
Huang, Jinyan (author)
Ma, Baoshan (author)
Ye, Yuanqing (author)
Chiu, Brian C. H. (author)
Sampson, Joshua (author)
Liang, Liming (author)
Park, Ju-Hyun (author)
Chung, Charles C. (author)
Weisenburger, Dennis D. (author)
Chatterjee, Nilanjan (author)
Fraumeni, Joseph F., Jr. (author)
Slager, Susan L. (author)
Wu, Xifeng (author)
de Sanjose, Silvia (author)
Smedby, Karin E. (author)
Salles, Gilles (author)
Skibola, Christine F. (author)
Rothman, Nathaniel (author)
Chanock, Stephen J. (author)
Karolinska InstitutetEnheten för onkologi (creator_code:org_t)

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In:Nature Genetics: Springer Science and Business Media LLC46:11, s. 1233-12381061-40361546-1718

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By the author/editor: Cerhan, James R.; Berndt, Sonja I.; Vijai, Joseph; Ghesquieres, Her ...; McKay, James; Wang, Sophia S.; show more...; Wang, Zhaoming; Yeager, Meredith; Conde, Lucia; de Bakker, Paul ...; Nieters, Alexand ...; Cox, David; Burdett, Laurie; Monnereau, Alain; Flowers, Christo ...; De Roos, Annecla ...; Brooks-Wilson, A ...; Lan, Qing; Severi, Gianluca; Melbye, Mads; Gu, Jian; Jackson, Rebecca ...; Kane, Eleanor; Teras, Lauren R.; Purdue, Mark P.; Vajdic, Claire M ...; Spinelli, John J ...; Giles, Graham G.; Albanes, Demetri ...; Kelly, Rachel S.; Zucca, Mariagraz ...; Bertrand, Kimber ...; Zeleniuch-Jacquo ...; Lawrence, Charle ...; Hutchinson, Amy; Zhi, Degui; Habermann, Thoma ...; Link, Brian K.; Novak, Anne J.; Dogan, Ahmet; Asmann, Yan W.; Liebow, Mark; Thompson, Carrie ...; Ansell, Stephen ...; Witzig, Thomas E ...; Weiner, George J ...; Veron, Amelie S.; Zelenika, Diana; Tilly, Herve; Haioun, Corinne; Molina, Thierry ...; Hjalgrim, Henrik; Glimelius, Bengt; Adami, Hans-Olov; Bracci, Paige M.; Riby, Jacques; Smith, Martyn T.; Holly, Elizabeth ...; Cozen, Wendy; Hartge, Patricia; Morton, Lindsay ...; Severson, Richar ...; Tinker, Lesley F ...; North, Kari E.; Becker, Nikolaus; Benavente, Yolan ...; Boffetta, Paolo; Brennan, Paul; Foretova, Lenka; Maynadie, Marc; Staines, Anthony; Lightfoot, Tracy; Crouch, Simon; Smith, Alex; Roman, Eve; Diver, W. Ryan; Offit, Kenneth; Zelenetz, Andrew; Klein, Robert J.; Villano, Danylo ...; Zheng, Tongzhang; Zhang, Yawei; Holford, Theodor ...; Kricker, Anne; Turner, Jenny; Southey, Melissa ...; Clavel, Jacqueli ...; Virtamo, Jarmo; Weinstein, Steph ...; Riboli, Elio; Vineis, Paolo; Kaaks, Rudolph; Trichopoulos, Di ...; Vermeulen, Roel ...; Boeing, Heiner; Tjonneland, Anne; Angelucci, Emanu ...; Di Lollo, Simone ...; Rais, Marco; Birmann, Brenda ...; Laden, Francine; Giovannucci, Edw ...; Kraft, Peter; Huang, Jinyan; Ma, Baoshan; Ye, Yuanqing; Chiu, Brian C. H ...; Sampson, Joshua; Liang, Liming; Park, Ju-Hyun; Chung, Charles C ...; Weisenburger, De ...; Chatterjee, Nila ...; Fraumeni, Joseph ...; Slager, Susan L.; Wu, Xifeng; de Sanjose, Silv ...; Smedby, Karin E.; Salles, Gilles; Skibola, Christi ...; Rothman, Nathani ...; Chanock, Stephen ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

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