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Markers of imminent...
Markers of imminent myocardial infarction
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- Gustafsson, Stefan (author)
- Uppsala University,Uppsala universitet,Klinisk epidemiologi
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- Lampa, Erik, 1977- (author)
- Uppsala University,Uppsala universitet,Klinisk epidemiologi
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- Jensevik, Karin (author)
- Uppsala University,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Butterworth, Adam S. (author)
- University of Cambridge
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- Elmståhl, Sölve (author)
- Lund University,Lunds universitet,Geriatrik,Forskargrupper vid Lunds universitet,Geriatrics,Lund University Research Groups,Skåne University Hospital
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- Engström, Gunnar (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Hveem, Kristian (author)
- Norwegian University of Science and Technology
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- Johansson, Mattias (author)
- International Agency for Research on Cancer, World Health Organization
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- Langhammer, Arnulf (author)
- Norwegian University of Science and Technology
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- Lind, Lars (author)
- Uppsala University,Uppsala universitet,Klinisk epidemiologi
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Läll, Kristi (author)
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- Masala, Giovanna (author)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
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- Metspalu, Andres (author)
- University of Tartu
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- Moreno-Iribas, Conchi (author)
- Health Research Institute of Navarra (IDISNA)
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- Nilsson, Peter M. (author)
- Skåne University Hospital
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- Perola, Markus (author)
- Finnish National Institute for Health and Welfare
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- Simell, Birgit (author)
- Finnish National Institute for Health and Welfare
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Sipsma, Hemmo (author)
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- Åsvold, Bjørn Olav (author)
- St. Olav’s University Hospital,Norwegian University of Science and Technology
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- Ingelsson, Erik, 1975- (author)
- Uppsala University,Uppsala universitet,Molekylär epidemiologi
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- Hammar, Ulf (author)
- Uppsala University,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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- Ganna, Andrea (author)
- Broad Institute,University of Helsinki,Massachusetts General Hospital
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- Svennblad, Bodil (author)
- Uppsala University,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Medicinsk epidemiologi
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- Fall, Tove, 1979- (author)
- Uppsala University,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi
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- Sundström, Johan, Professor, 1971- (author)
- Uppsala University,Uppsala universitet,Klinisk epidemiologi,The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Nature Cardiovascular Research. - : Springer Nature. - 2731-0590.
- Related links:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Myocardial infarction is a leading cause of death globally but is notoriously difficult to predict. We aimed to identify biomarkers of an imminent first myocardial infarction and design relevant prediction models. Here, we constructed a new case–cohort consortium of 2,018 persons without prior cardiovascular disease from six European cohorts, among whom 420 developed a first myocardial infarction within 6 months after the baseline blood draw. We analyzed 817 proteins and 1,025 metabolites in biobanked blood and 16 clinical variables. Forty-eight proteins, 43 metabolites, age, sex and systolic blood pressure were associated with the risk of an imminent first myocardial infarction. Brain natriuretic peptide was most consistently associated with the risk of imminent myocardial infarction. Using clinically readily available variables, we devised a prediction model for an imminent first myocardial infarction for clinical use in the general population, with good discriminatory performance and potential for motivating primary prevention efforts.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Gustafsson, Stef ...
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Lampa, Erik, 197 ...
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Jensevik, Karin
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Butterworth, Ada ...
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Elmståhl, Sölve
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Engström, Gunnar
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show more...
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Hveem, Kristian
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Johansson, Matti ...
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Langhammer, Arnu ...
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Lind, Lars
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Läll, Kristi
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Masala, Giovanna
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Metspalu, Andres
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Moreno-Iribas, C ...
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Nilsson, Peter M ...
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Perola, Markus
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Simell, Birgit
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Sipsma, Hemmo
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Åsvold, Bjørn Ol ...
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Ingelsson, Erik, ...
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Hammar, Ulf
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Ganna, Andrea
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Svennblad, Bodil
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Fall, Tove, 1979 ...
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Sundström, Johan ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Nature Cardiovas ...
- By the university
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Uppsala University
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Lund University