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Impact of presentat...
Impact of presentation and transfer delays on complete ST-segment resolution before primary percutaneous coronary intervention : insights from the ATLANTIC trial.
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- Fabris, Enrico (författare)
- Isala Clinics, Zwolle, the Netherlands, University of Trieste, Trieste, Italy
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- Van't Hof, Arnoud (författare)
- Isala Clinics, Zwolle, the Netherlands
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- Hamm, Christian W (författare)
- Kerckhoff Heart and Thorax Center, Bad Nauheim, Germany
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- Lapostolle, Frédéric (författare)
- Hôpital Avicenne, Bobigny, France
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- Lassen, Jens Flensted (författare)
- Aarhus University Hospital, Aarhus N, Denmark
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- Goodman, Shaun G (författare)
- St. Michael’s Hospital, University of Toronto, Toronto, Canada
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- Ten Berg, Jurriën M (författare)
- Antonius Hospital Nieuwegein, Nieuwegein, the Netherlands
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- Bolognese, Leonardo (författare)
- Cardiovascular and Neurological Department, Azienda Ospedaliera Arezzo, Arezzo, Italy
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- Cequier, Angel (författare)
- University of Barcelona, Barcelona, Spain
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- Chettibi, Mohamed (författare)
- Centre Hospitalo Universitaire Frantz Fanon, Blida, Algeria
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- Hammett, Christopher H (författare)
- Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia
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- Huber, Kurt (författare)
- Wilhelminen Hospital and Sigmund Freud Private University, Medical School, Vienna, Austria
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- Janzon, Magnus (författare)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Merkely, Béla (författare)
- Heart and Vascular Center, Semmelweis University, Budapest, Hungary
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- Storey, Robert F (författare)
- University of Sheffield, Sheffield, United Kingdom
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- Zeymer, Uwe (författare)
- Klinikum Ludwigshafen and Institut für Herzinfarktforschung, Ludwigshafen, Germany
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- Cantor, Warren J (författare)
- University of Toronto, Newmarket, Ontario, Canada;
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- Rousseau, Hélène (författare)
- Hospital Lariboisiere, ACTION Study Group, Paris, France
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- Vicaut, Eric (författare)
- Hospital Lariboisiere, ACTION Study Group, Paris, France
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- Montalescot, Gilles (författare)
- Sorbonne Université Paris 6, ACTION Study Group, Hospital Pitie-Salpetriere (AP-HP), Paris, France
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(creator_code:org_t)
- 2017
- 2017
- Engelska.
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Ingår i: EuroIntervention. - 1774-024X .- 1969-6213. ; 13:1, s. 69-77
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.4...
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Abstract
Ämnesord
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- AIMS: The aim of this study was to identify predictors of complete ST-segment resolution (STR) pre-primary percutaneous coronary intervention (PCI) in patients enrolled in the ATLANTIC trial.METHODS AND RESULTS: ECGs recorded at the time of inclusion (pre-hospital [pre-H]-ECG) and in the catheterisation laboratory before angiography (pre-PCI-ECG) were analysed by an independent core laboratory. Complete STR was defined as ≥70%. Complete STR occurred pre-PCI in 12.8% (204/1,598) of patients and predicted lower 30-day composite MACCE (OR=0.10, 95% CI: 0.002-0.57, p=0.001) and total mortality (OR=0.16, 95% CI: 0.004-0.95, p=0.035). Independent predictors of complete STR included the time from index event to pre-H-ECG (OR=0.94, 95% CI: 0.89-1.00, p=0.035), use of heparins before pre-PCI-ECG (OR=1.75, 95% CI: 1.25-2.45, p=0.001) and time from pre-H-ECG to pre-PCI-ECG (OR=1.09, 95% CI: 1.03-1.16, p=0.005). In the pre-H ticagrelor group, patients with complete STR had a significantly longer delay between pre-H-ECG and pre-PCI-ECG compared to patients without complete STR (median 53 [44-73] vs. 49 [38.5-61] mins, p=0.001); however, this was not observed in the control group (in-hospital ticagrelor) (50 [40-67] vs. 49 [39-61] mins, p=0.258).CONCLUSIONS: Short patient delay, early administration of anticoagulant and ticagrelor if a long transfer delay is expected may help to achieve reperfusion prior to PCI. Pre-H treatment may be beneficial in patients with longer transfer delays, allowing the drug to become biologically active.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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Fabris, Enrico
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Van't Hof, Arnou ...
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Hamm, Christian ...
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Lapostolle, Fréd ...
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Lassen, Jens Fle ...
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Goodman, Shaun G
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Ten Berg, Jurrië ...
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Bolognese, Leona ...
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Cequier, Angel
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Chettibi, Mohame ...
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Hammett, Christo ...
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Huber, Kurt
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Janzon, Magnus
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Merkely, Béla
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Storey, Robert F
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Zeymer, Uwe
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Cantor, Warren J
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Rousseau, Hélène
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Vicaut, Eric
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Montalescot, Gil ...
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