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Subcortical volumet...
Subcortical volumetric abnormalities in bipolar disorder
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Hibar, D. P. (author)
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Westlye, L. T. (author)
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Van Erp, T. G. M. (author)
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show more...
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Rasmussen, J. (author)
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Leonardo, C. D. (author)
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Faskowitz, J. (author)
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Haukvik, U. K. (author)
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Hartberg, C. B. (author)
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Doan, N. T. (author)
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- Agartz, I. (author)
- Karolinska Institutet
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Dale, A. M. (author)
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Gruber, O. (author)
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Krämer, B. (author)
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Trost, S. (author)
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Liberg, B. (author)
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- Abé, C. (author)
- Karolinska Institutet
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- Ekman, C. J. (author)
- Karolinska Institutet
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- Ingvar, M. (author)
- Karolinska Institutet
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- Landén, Mikael, 1966 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Fears, S. C. (author)
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Freimer, N. B. (author)
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Bearden, C. E. (author)
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Sprooten, E. (author)
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Glahn, D. C. (author)
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Pearlson, G. D. (author)
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Emsell, L. (author)
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Kenney, J. (author)
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Scanlon, C. (author)
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McDonald, C. (author)
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Cannon, D. M. (author)
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Almeida, J. (author)
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Versace, A. (author)
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Caseras, X. (author)
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Lawrence, N. S. (author)
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Phillips, M. L. (author)
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Dima, D. (author)
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Delvecchio, G. (author)
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Frangou, S. (author)
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Satterthwaite, T. D. (author)
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Wolf, D. (author)
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Houenou, J. (author)
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Henry, C. (author)
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Malt, U. F. (author)
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BØen, E. (author)
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Elvs'shagen, T. (author)
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Young, A. H. (author)
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Lloyd, A. J. (author)
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Goodwin, G. M. (author)
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Mackay, C. E. (author)
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Bourne, C. (author)
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Bilderbeck, A. (author)
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Abramovic, L. (author)
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Boks, M. P. (author)
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Van Haren, N. E. M. (author)
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Ophoff, R. A. (author)
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Kahn, R. S. (author)
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Bauer, M. (author)
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Pfennig, A. (author)
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Alda, M. (author)
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Hajek, T. (author)
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Mwangi, B. (author)
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Soares, J. C. (author)
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Nickson, T. (author)
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Dimitrova, R. (author)
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Sussmann, J. E. (author)
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Hagenaars, S. (author)
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Whalley, H. C. (author)
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McIntosh, A. M. (author)
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Thompson, P. M. (author)
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Andreassen, O. A. (author)
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Elvsashagen, T (author)
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(creator_code:org_t)
- 2016-02-09
- 2016
- English.
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In: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 21:12, s. 1710-1716
- Related links:
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https://www.nature.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Considerable uncertainty exists about the defining brain changes associated with bipolar disorder (BD). Understanding and quantifying the sources of uncertainty can help generate novel clinical hypotheses about etiology and assist in the development of biomarkers for indexing disease progression and prognosis. Here we were interested in quantifying case-control differences in intracranial volume (ICV) and each of eight subcortical brain measures: nucleus accumbens, amygdala, caudate, hippocampus, globus pallidus, putamen, thalamus, lateral ventricles. In a large study of 1710 BD patients and 2594 healthy controls, we found consistent volumetric reductions in BD patients for mean hippocampus (Cohen's d=-0.232; P=3.50 × 10 -7) and thalamus (d=-0.148; P=4.27 × 10 -3) and enlarged lateral ventricles (d=-0.260; P=3.93 × 10 -5) in patients. No significant effect of age at illness onset was detected. Stratifying patients based on clinical subtype (BD type I or type II) revealed that BDI patients had significantly larger lateral ventricles and smaller hippocampus and amygdala than controls. However, when comparing BDI and BDII patients directly, we did not detect any significant differences in brain volume. This likely represents similar etiology between BD subtype classifications. Exploratory analyses revealed significantly larger thalamic volumes in patients taking lithium compared with patients not taking lithium. We detected no significant differences between BDII patients and controls in the largest such comparison to date. Findings in this study should be interpreted with caution and with careful consideration of the limitations inherent to meta-analyzed neuroimaging comparisons. © 2016 Macmillan Publishers Limited, part of Springer Nature.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Hibar, D. P.
-
Westlye, L. T.
-
Van Erp, T. G. M ...
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Rasmussen, J.
-
Leonardo, C. D.
-
Faskowitz, J.
-
show more...
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Haukvik, U. K.
-
Hartberg, C. B.
-
Doan, N. T.
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Agartz, I.
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Dale, A. M.
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Gruber, O.
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Krämer, B.
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Trost, S.
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Liberg, B.
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Abé, C.
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Ekman, C. J.
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Ingvar, M.
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Landén, Mikael, ...
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Fears, S. C.
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Freimer, N. B.
-
Bearden, C. E.
-
Sprooten, E.
-
Glahn, D. C.
-
Pearlson, G. D.
-
Emsell, L.
-
Kenney, J.
-
Scanlon, C.
-
McDonald, C.
-
Cannon, D. M.
-
Almeida, J.
-
Versace, A.
-
Caseras, X.
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Lawrence, N. S.
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Phillips, M. L.
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Dima, D.
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Delvecchio, G.
-
Frangou, S.
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Satterthwaite, T ...
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Wolf, D.
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Houenou, J.
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Henry, C.
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Malt, U. F.
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BØen, E.
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Elvs'shagen, T.
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Young, A. H.
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Lloyd, A. J.
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Goodwin, G. M.
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Mackay, C. E.
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Bourne, C.
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Bilderbeck, A.
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Abramovic, L.
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Boks, M. P.
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Van Haren, N. E. ...
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Ophoff, R. A.
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Kahn, R. S.
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Bauer, M.
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Pfennig, A.
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Alda, M.
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Hajek, T.
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Mwangi, B.
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Soares, J. C.
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Nickson, T.
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Dimitrova, R.
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Sussmann, J. E.
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Hagenaars, S.
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Whalley, H. C.
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McIntosh, A. M.
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Thompson, P. M.
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Andreassen, O. A ...
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Elvsashagen, T
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Molecular Psychi ...
- By the university
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University of Gothenburg
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Karolinska Institutet