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Sökning: (WFRF:(Gislason G)) > (2020-2024) > Cross-sectional stu...

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FältnamnIndikatorerMetadata
00007045naa a2200985 4500
001oai:gup.ub.gu.se/308705
003SwePub
008240528s2022 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-187892
009oai:DiVA.org:du-38295
009oai:DiVA.org:uu-435003
0247 a https://gup.ub.gu.se/publication/3087052 URI
0247 a https://doi.org/10.1111/cea.140192 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1878922 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:du-382952 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4350032 URI
040 a (SwePub)gud (SwePub)umud (SwePub)dud (SwePub)uu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Krantz, Christinau Uppsala universitet,Institutionen för kvinnors och barns hälsa,Pediatrisk inflammations- och metabolismforskning samt barnhälsa, Paediatric Inflammation, Metabolism and Child Health Research4 aut0 (Swepub:uu)chrah730
2451 0a Cross-sectional study on exhaled nitric oxide in relation to upper airway inflammatory disorders with regard to asthma and perennial sensitization
264 c 2021-10-05
264 1b Wiley,c 2022
520 a Background Fractional exhaled nitric oxide (FeNO) is a well-known marker of type-2 inflammation. FeNO is elevated in asthma and allergic rhinitis, with IgE sensitization as a major determinant. Objective We aimed to see whether there was an independent association between upper airway inflammatory disorders (UAID) and FeNO, after adjustment for asthma and sensitization, in a multi-centre population-based study. Methods A total of 741 subjects with current asthma and 4155 non-asthmatic subjects participating in the second follow-up of the European Community Respiratory Health Survey (ECRHS III) underwent FeNO measurements. Sensitization status was based on measurement of IgE against airborne allergens; information on asthma, UAID and medication was collected through interview-led questionnaires. Independent associations between UAID and FeNO were assessed in adjusted multivariate regression models and test for interaction with perennial sensitization and asthma on the relation between UAID and FeNO were made. Results UAID were associated with higher FeNO after adjusting for perennial sensitization, asthma and other confounders: with 4.4 (0.9-7.9) % higher FeNO in relation to current rhinitis and 4.8 (0.7-9.2) % higher FeNO in relation to rhinoconjunctivitis. A significant interaction with perennial sensitization was found in the relationship between current rhinitis and FeNO (p = .03) and between rhinoconjunctivitis and FeNO (p = .03). After stratification by asthma and perennial sensitization, the association between current rhinitis and FeNO remained in non-asthmatic subjects with perennial sensitization, with 12.1 (0.2-25.5) % higher FeNO in subjects with current rhinitis than in those without. Conclusions & Clinical Relevance Current rhinitis and rhinoconjunctivitis was associated with higher FeNO, with an interaction with perennial sensitization. This further highlights the concept of united airway disease, with correlations between symptoms and inflammation in the upper and lower airways and that sensitization needs to be accounted for in the relation between FeNO and rhinitis.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
653 a asthma
653 a exhaled nitric oxide
653 a FeNO
653 a nasal polyposis
653 a population-based
653 a rhinitis
653 a respiratory-health-survey
653 a allergic rhinitis
653 a geographical variation
653 a potential biomarker
653 a ige sensitization
653 a community
653 a nasal
653 a atopy
653 a aeroallergens
653 a impairment
653 a Allergy
653 a Immunology
653 a FeNO
7001 a Accordini, S.4 aut
7001 a Alving, Kjell,d 1959-u Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa4 aut0 (Swepub:uu)kjeal631
7001 a Corsico, A. G.4 aut
7001 a Demoly, P.4 aut
7001 a Ferreira, D. S.4 aut
7001 a Forsberg, Bertil,c professor,d 1956-u Umeå universitet,Avdelningen för hållbar hälsa4 aut0 (Swepub:umu)befo0001
7001 a Garcia-Aymerich, J.4 aut
7001 a Gislason, T.4 aut
7001 a Heinrich, J.4 aut
7001 a Jogi, R.4 aut
7001 a Johannessen, A.4 aut
7001 a Leynaert, B.4 aut
7001 a Marcon, A.4 aut
7001 a Rovira, J. M. M.4 aut
7001 a Nerpin, Elisabet,d 1962-u Högskolan Dalarna,Medicinsk vetenskap,Uppsala University4 aut0 (Swepub:du)ene
7001 a Nowak, D.4 aut
7001 a Olin, Anna-Carin,d 1960u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine4 aut0 (Swepub:gu)xolina
7001 a Olivieri, M.4 aut
7001 a Pereira-Vega, A.4 aut
7001 a Raherison-Semjen, C.4 aut
7001 a Real, F. G.4 aut
7001 a Sigsgaard, T.4 aut
7001 a Squillacioti, G.4 aut
7001 a Janson, Christeru Uppsala universitet,Arbets- och miljömedicin,Lung- allergi- och sömnforskning4 aut0 (Swepub:uu)chrisjn
7001 a Malinovschi, Andrei,d 1978-u Uppsala universitet,Integrativ Fysiologi,Klinisk fysiologi,Lung- allergi- och sömnforskning4 aut0 (Swepub:uu)anmal535
7001 a Survey III, The European Community Respiratory Health4 aut
7102 a Uppsala universitetb Institutionen för kvinnors och barns hälsa4 org
7730 t Clinical and Experimental Allergyd : Wileyg 52:2, s. 297-311q 52:2<297-311x 0954-7894x 1365-2222
8564 u https://iris.unito.it/bitstream/2318/1827128/1/Clin%20Experimental%20Allergy%20-%202021%20-%20Krantz%20-%20Cross%e2%80%90sectional%20study%20on%20exhaled%20nitric%20oxide%20in%20relation%20to%20upper%20airway.pdf
8564 u https://doi.org/10.1111/cea.14019y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1596839/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://du.diva-portal.org/smash/get/diva2:1597637/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print
8564 u https://uu.diva-portal.org/smash/get/diva2:1529436/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://gup.ub.gu.se/publication/308705
8564 8u https://doi.org/10.1111/cea.14019
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-187892
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:du-38295
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-435003

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