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Sökning: (WFRF:(Heneka Michael)) > Higher CSF Tau Leve...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005455naa a2200505 4500
001oai:lup.lub.lu.se:251e56c7-e696-4550-922a-160962904ba6
003SwePub
008191115s2019 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/251e56c7-e696-4550-922a-160962904ba62 URI
0247 a https://doi.org/10.1523/JNEUROSCI.1279-19.20192 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Berron, Davidu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,German Center for Neurodegenerative Diseases (DZNE) Magdeburg,Otto von Guericke University Magdeburg4 aut0 (Swepub:lu)da1401be
2451 0a Higher CSF Tau Levels Are Related to Hippocampal Hyperactivity and Object Mnemonic Discrimination in Older Adults
264 1c 2019
300 a 10 s.
520 a Mnemonic discrimination, the ability to distinguish similar events in memory, relies on subregions in the human medial temporal lobes (MTLs). Tau pathology is frequently found within the MTL of older adults and therefore likely to affect mnemonic discrimination, even in healthy older individuals. The MTL subregions that are known to be affected early by tau pathology, the perirhinal-transentorhinal region (area 35) and the anterior-lateral entorhinal cortex (alEC), have recently been implicated in the mnemonic discrimination of objects rather than scenes. Here we used an object-scene mnemonic discrimination task in combination with fMRI recordings and analyzed the relationship between subregional MTL activity, memory performance, and levels of total and phosphorylated tau as well as Aβ42/40 ratio in CSF. We show that activity in alEC was associated with mnemonic discrimination of similar objects but not scenes in male and female cognitively unimpaired older adults. Importantly, CSF tau levels were associated with increased fMRI activity in the hippocampus, and both increased hippocampal activity as well as tau levels were associated with mnemonic discrimination of objects, but again not scenes. This suggests that dysfunction of the alEC-hippocampus object mnemonic discrimination network might be a marker for tau-related cognitive decline.SIGNIFICANCE STATEMENT Subregions in the human medial temporal lobe are critically involved in episodic memory and, at the same time, affected by tau pathology. Impaired object mnemonic discrimination performance as well as aberrant activity within the entorhinal-hippocampal circuitry have been reported in earlier studies involving older individuals, but it has thus far remained elusive whether and how tau pathology is implicated in this specific impairment. Using task-related fMRI in combination with measures of tau pathology in CSF, we show that measures of tau pathology are associated with increased hippocampal activity and reduced mnemonic discrimination of similar objects but not scenes. This suggests that object mnemonic discrimination tasks could be promising markers for tau-related cognitive decline.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653 a ageing
653 a CSF
653 a entorhinal cortex
653 a fMRI
653 a hippocampus
653 a mnemonic discrimination
7001 a Cardenas-Blanco, Arturou Otto von Guericke University Magdeburg,German Center for Neurodegenerative Diseases (DZNE) Magdeburg4 aut
7001 a Bittner, Danielu University Hospital Magdeburg4 aut
7001 a Metzger, Coraline D.u German Center for Neurodegenerative Diseases (DZNE) Magdeburg,Otto von Guericke University Magdeburg4 aut
7001 a Spottke, Annikau German Center for Neurodegenerative Diseases (DZNE), Bonn,University Hospital Bonn4 aut
7001 a Heneka, Michael T.u University of Bonn,German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut
7001 a Fliessbach, Klausu University of Bonn,German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut
7001 a Schneider, Anjau University of Bonn,German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut
7001 a Teipel, Stefan J.u Universitätsmedizin Rostock4 aut
7001 a Wagner, Michaelu University of Bonn,German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut
7001 a Speck, Oliveru German Center for Neurodegenerative Diseases (DZNE) Magdeburg,Otto von Guericke University Magdeburg4 aut
7001 a Jessen, Franku University Hospital of Cologne,German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut
7001 a Düzel, Emrahu German Center for Neurodegenerative Diseases (DZNE) Magdeburg,Otto von Guericke University Magdeburg,University College London4 aut
7102 a Klinisk minnesforskningb Forskargrupper vid Lunds universitet4 org
7730 t The Journal of Neuroscience : the official journal of the Society for Neuroscienceg 39:44, s. 8788-8797q 39:44<8788-8797x 1529-2401
8564 u http://dx.doi.org/10.1523/JNEUROSCI.1279-19.2019x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/251e56c7-e696-4550-922a-160962904ba6
8564 8u https://doi.org/10.1523/JNEUROSCI.1279-19.2019

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