Sökning: (WFRF:(Hornsby Whitney)) > Birth Weight Is Ass...
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000 | 05076naa a2200529 4500 | |
001 | oai:lup.lub.lu.se:ce0c9de5-4f8c-4c8b-b3a1-48ff1099c060 | |
003 | SwePub | |
008 | 230906s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/ce0c9de5-4f8c-4c8b-b3a1-48ff1099c0602 URI |
024 | 7 | a https://doi.org/10.1161/JAHA.123.0302202 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Schuermans, Artu Massachusetts General Hospital,Broad Institute4 aut |
245 | 1 0 | a Birth Weight Is Associated With Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Adulthood |
264 | 1 | c 2023 |
520 | a BACKGROUND: High and low birth weight are independently associated with increased cardiovascular disease risk in adulthood. Clonal hematopoiesis of indeterminate potential (CHIP), the age-related clonal expansion of hematopoietic cells with preleu-kemic somatic mutations, predicts incident cardiovascular disease independent of traditional cardiovascular risk factors. Whether birth weight predicts development of CHIP later in life is unknown. METHODS AND RESULTS: A total of 221 047 adults enrolled in the UK Biobank with whole exome sequences and self-reported birth weight were analyzed. Of those, 22 030 (11.5%) had low (<2.5 kg) and 29 292 (14.7%) high birth weight (>4.0 kg). CHIP prevalence was higher among participants with low (6.0%, P=0.049) and high (6.3%, P<0.001) versus normal birth weight (5.7%, ref.). Multivariable-adjusted logistic regression analyses demonstrated that each 1-kg increase in birth weight was associated with a 3% increased risk of CHIP (odds ratio, 1.03 [95% CI, 1.00–1.06]; P=0.04), driven by a stronger association ob-served between birth weight and DNMT3A CHIP (odds ratio, 1.04 per 1-kg increase [95% CI, 1.01–1.08]; P=0.02). Mendelian randomization analyses supported a causal relationship of longer gestational age at delivery with DNMT3A CHIP. Multivariable Cox regression demonstrated that CHIP was independently and additively associated with incident cardiovascular disease or death across birth weight groups, with highest absolute risks in those with CHIP plus high or low birth weight. CONCLUSIONS: Higher birth weight is associated with increased risk of developing CHIP in midlife, especially DNMT3A CHIP. These findings identify a novel risk factor for CHIP and provide insights into the relationships among early-life environment, CHIP, cancer, and cardiovascular disease. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
653 | a birth weight | |
653 | a cardiovascular disease | |
653 | a clonal hematopoiesis | |
653 | a early life | |
653 | a genetics | |
700 | 1 | a Nakao, Tetsushiu Massachusetts General Hospital,Broad Institute,Brigham and Women's Hospital / Harvard Medical School4 aut |
700 | 1 | a Ruan, Yunfengu Massachusetts General Hospital,Broad Institute4 aut |
700 | 1 | a Koyama, Satoshiu Broad Institute,Massachusetts General Hospital4 aut0 (Swepub:lu)sa2525ko |
700 | 1 | a Yu, Zhiu Massachusetts General Hospital,Broad Institute4 aut |
700 | 1 | a Uddin, Md Mesbahu Massachusetts General Hospital,Broad Institute4 aut |
700 | 1 | a Haidermota, Sarau Broad Institute,Massachusetts General Hospital4 aut |
700 | 1 | a Hornsby, Whitneyu Massachusetts General Hospital,Broad Institute4 aut |
700 | 1 | a Lewandowski, Adam J.u University of Oxford4 aut |
700 | 1 | a Bick, Alexander G.u Vanderbilt University Medical Center4 aut |
700 | 1 | a Niroula, Abhisheku Lund University,Lunds universitet,Institutionen för laboratoriemedicin,Medicinska fakulteten,Department of Laboratory Medicine,Faculty of Medicine,Broad Institute,Dana-Farber Cancer Institute4 aut0 (Swepub:lu)med-anu |
700 | 1 | a Jaiswal, Siddharthau Stanford University School of Medicine4 aut |
700 | 1 | a Ebert, Benjamin L.u Howard Hughes Medical Institute,Dana-Farber Cancer Institute4 aut |
700 | 1 | a Natarajan, Pradeepu Harvard Medical School,Massachusetts General Hospital,Broad Institute4 aut |
700 | 1 | a Honigberg, Michael C.u Harvard Medical School,Broad Institute,Massachusetts General Hospital4 aut |
710 | 2 | a Massachusetts General Hospitalb Broad Institute4 org |
773 | 0 | t Journal of the American Heart Associationg 12:13q 12:13x 2047-9980 |
856 | 4 | u http://dx.doi.org/10.1161/JAHA.123.030220x freey FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/ce0c9de5-4f8c-4c8b-b3a1-48ff1099c060 |
856 | 4 8 | u https://doi.org/10.1161/JAHA.123.030220 |
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