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Intravesical instil...
Intravesical instillations and cancer-specific survival in patients with primary carcinoma in situ of the urinary bladder
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- Jancke, Georg (author)
- Lund University,Lunds universitet,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,Urology - urothelial cancer, Malmö,Lund University Research Groups,Skåne University Hospital, Sweden; Lund University, Sweden,Skane Univ Hosp, Dept Urol, Malmo, Sweden.;Lund Univ, Dept Translat Med, Malmo, Sweden.
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- Liedberg, Fredrik (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Urology - urothelial cancer, Malmö,Lund University Research Groups,Skåne University Hospital, Sweden; Lund University, Sweden,Skane Univ Hosp, Dept Urol, Malmo, Sweden.;Lund Univ, Dept Translat Med, Malmo, Sweden.
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- Aljabery, Firas (author)
- Linköping University Hospital,Region Östergötland, Urologiska kliniken i Östergötland,Linkoping Univ Hosp, Dept Urol, Linkoping, Sweden.
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- Sherif, Amir (author)
- Norrland University Hospital, Sweden,Norrland Univ Hosp, Dept Urol, Umea, Sweden.
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- Ströck, Viveka (author)
- Sahlgrens University Hospital, Sweden,Sahlgrens Univ Hosp, Dept Urol, Gothenburg, Sweden.
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- Malmström, Per-Uno (author)
- Uppsala universitet,Urologkirurgi
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- Hosseini-Aliabad, Abolfazl (author)
- Karolinska University Hospital, Sweden,Karolinska Univ Hosp, Dept Urol, Stockholm, Sweden.
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- Jahnson, Staffan (author)
- Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland,Linkoping Univ Hosp, Dept Urol, Linkoping, Sweden.
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(creator_code:org_t)
- 2017-03-29
- 2017
- English.
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In: Scandinavian journal of urology. - : Taylor & Francis. - 2168-1805 .- 2168-1813. ; 51:2, s. 124-129
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Abstract
Subject headings
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- OBJECTIVE: The aim of this study was to evaluate the use of intravesical treatment and cancer-specific survival of patients with primary carcinoma in situ (CIS).MATERIALS AND METHODS: Data acquisition was based on the Swedish National Registry of Urinary Bladder Cancer by selecting all patients with primary CIS. The analysis covered gender, age, hospital type and hospital volume. Intravesical treatment and death due to bladder cancer were evaluated by multivariate logistic regression and multivariate Cox analysis, respectively.RESULTS: The study included 1041 patients (median age at diagnosis 72 years) with a median follow-up of 65 months. Intravesical instillation therapy was given to 745 patients (72%), and 138 (13%) died from bladder cancer during the observation period. Male gender [odds ratio (OR) = 1.56, 95% confidence interval (CI) 1.13-2.17] and treatment at county (OR = 1.65, 95% CI 1.17-2.33), university (OR =2.12, 95% CI 1.48-3.03) or high-volume (OR = 1.92, 95% CI 1.34-2.75) hospitals were significantly associated with higher odds of intravesical instillations. The age category ≥80 years had a significantly lower chance of receiving intravesical therapy (OR = 0.44, 95% CI 0.26-0.74) and a significantly higher risk of dying from bladder cancer (hazard ratio = 3.03, 95% CI 1.71-5.35).CONCLUSION: Significantly more frequent use of intravesical treatment of primary CIS was found for males and for patients treated at county, university and high-volume hospitals. Age ≥80 years was significantly related to less intravesical treatment and poorer cancer-specific survival.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Cancer-specific survival
- intravesical treatment
- primary CIS
- Cancer-specific survival
- intravesical treatment
- primary CIS
Publication and Content Type
- ref (subject category)
- art (subject category)
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