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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 28765naa a2202053 4500 | |
| 001 | oai:DiVA.org:umu-123447 | |
| 003 | SwePub | |
| 008 | 160704s2016 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:5473991d-29f0-4f9e-8d92-a4018d3fbb98 | |
| 009 | oai:DiVA.org:uu-299503 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1234472 URI |
| 024 | 7 | a https://doi.org/10.1126/scitranslmed.aad37442 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/5473991d-29f0-4f9e-8d92-a4018d3fbb982 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2995032 URI |
| 040 | a (SwePub)umud (SwePub)lud (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Scott, Robert A.u University of Cambridge,Univ Cambridge, Sch Clin Med, MRC, Epidemiol Unit,Inst Metab Sci, Cambridge Biomedical Campus, Cambridge CB2 0QQ, England.4 aut |
| 245 | 1 0 | a A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease |
| 264 | 1 | b American Association for the Advancement of Science (AAAS),c 2016 |
| 338 | a print2 rdacarrier | |
| 520 | a Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic therapies by predicting cardiovascular and other health endpoints. We therefore investigated the association of variants in six genes that encode drug targets for obesity or T2D with a range of metabolic traits in up to 11,806 individuals by targeted exome sequencing and follow-up in 39,979 individuals by targeted genotyping, with additional in silico follow-up in consortia. We used these data to first compare associations of variants in genes encoding drug targets with the effects of pharmacological manipulation of those targets in clinical trials. We then tested the association of those variants with disease outcomes, including coronary heart disease, to predict cardiovascular safety of these agents. A low-frequency missense variant (Ala316Thr; rs10305492) in the gene encoding glucagon-like peptide-1 receptor (GLP1R), the target of GLP1R agonists, was associated with lower fasting glucose and T2D risk, consistent with GLP1R agonist therapies. The minor allele was also associated with protection against heart disease, thus providing evidence that GLP1R agonists are not likely to be associated with an unacceptable increase in cardiovascular risk. Our results provide an encouraging signal that these agents may be associated with benefit, a question currently being addressed in randomized controlled trials. Genetic variants associated with metabolic traits and multiple disease outcomes can be used to validate therapeutic targets at an early stage in the drug development process. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng |
| 700 | 1 | a Freitag, Daniel F.u University of Strasbourg,Univ Cambridge, Strangeways Res Lab, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England.;Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England.4 aut |
| 700 | 1 | a Li, Liu GlaxoSmithKline, Stat Genet Projects Clin Platforms & Sci PCPS, Res Triangle Pk, NC 27709 USA.,Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA.;NHLBI, Framingham Heart Study, Framingham, MA 01702 USA.,University of North Carolina,National Institute for Public Health and the Environment (RIVM),Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA.,Natl Inst Publ Hlth & Environm RIVM, NL-3720 BA Bilthoven, Netherlands.4 aut0 (Swepub:lu)wbl-lli |
| 700 | 1 | a Chu, Audrey Y.u Brigham and Women's Hospital / Harvard Medical School,Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA.4 aut |
| 700 | 1 | a Surendran, Praveenu University of Cambridge,Univ Cambridge, Strangeways Res Lab, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England.4 aut |
| 700 | 1 | a Young, Robinu University of Cambridge,Univ Cambridge, Strangeways Res Lab, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England.4 aut |
| 700 | 1 | a Grarup, Nielsu University of Copenhagen,Univ Copenhagen, NovoNordisk Fdn, Fac Hlth & Med Sci, Ctr Basic Metab Res, DK-2200 Copenhagen, Denmark.4 aut |
| 700 | 1 | a Stancakova, Alenau University of Eastern Finland,Univ Eastern Finland, Inst Clin Med, Internal Med, FI-70211 Kuopio, Finland.4 aut |
| 700 | 1 | a Chen, Yuningu Boston University,Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA.4 aut |
| 700 | 1 | a Varga, Tibor V.u Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Genet & Mol Epidemiol Unit, Dept Clin Sci, SE-205 Malmo, Sweden.4 aut0 (Swepub:lu)med-tv_ |
| 700 | 1 | a Yaghootkar, Haniehu University of Exeter,Univ Exeter, Sch Med, Genet Complex Traits, Exeter EX1 2LU, Devon, England.4 aut |
| 700 | 1 | a Luan, Jian'anu University of Cambridge,Univ Cambridge, Sch Clin Med, MRC, Epidemiol Unit,Inst Metab Sci, Cambridge Biomedical Campus, Cambridge CB2 0QQ, England.4 aut |
| 700 | 1 | a Zhao, Jing Huau University of Cambridge,Univ Cambridge, Sch Clin Med, MRC, Epidemiol Unit,Inst Metab Sci, Cambridge Biomedical Campus, Cambridge CB2 0QQ, England.4 aut |
| 700 | 1 | a Willems, Sara M.u Erasmus University Medical Center,Univ Cambridge, Sch Clin Med, MRC, Epidemiol Unit,Inst Metab Sci, Cambridge Biomedical Campus, Cambridge CB2 0QQ, England.;Erasmus Univ, Med Ctr, Dept Epidemiol, Genet Epidemiol Unit, NL-3000 CE Rotterdam, Netherlands.4 aut |
| 700 | 1 | a Wessel, Jenniferu Indiana University,Fairbanks Sch Publ Hlth, Dept Epidemiol, Indianapolis, IN 46202 USA.;Indiana Univ Sch Med, Dept Med, Indianapolis, IN 46202 USA.4 aut |
| 700 | 1 | a Wang, Shuaiu Boston University,Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA.4 aut |
| 700 | 1 | a Maruthur, Nisau Johns Hopkins University,Johns Hopkins Univ, Sch Med, Div Gen Internal Med, Baltimore, MD 21205 USA.;Johns Hopkins Univ, Welch Ctr Prevent Epidemol & Clin Res, Baltimore, MD 21205 USA.;Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA.4 aut |
| 700 | 1 | a Michailidou, Kyriakiu University of Cambridge,Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Strangeways Lab, Cambridge CB1 8RN, England.4 aut |
| 700 | 1 | a Pirie, Ailithu University of Cambridge,Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Strangeways Lab, Cambridge CB1 8RN, England.4 aut |
| 700 | 1 | a van der Lee, Sven J.u Erasmus University Medical Center,Erasmus Univ, Dept Epidemiol, Med Ctr, NL-3000 CA Rotterdam, Netherlands.4 aut |
| 700 | 1 | a Gillson, Christopheru University of Cambridge,Univ Cambridge, Sch Clin Med, MRC, Epidemiol Unit,Inst Metab Sci, Cambridge Biomedical Campus, Cambridge CB2 0QQ, England.4 aut |
| 700 | 1 | a Al Olama, Ali Aminu University of Cambridge,Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Strangeways Lab, Cambridge CB1 8RN, England.4 aut |
| 700 | 1 | a Amouyel, Philippeu University of Lille,Univ Lille, Ctr Hosp Reg Univ Lille, INSERM, Inst Pasteur Lille,UMR 1167,RID AGE, F-59000 Lille, France.4 aut |
| 700 | 1 | a Arriola, Larraitzu CIBER Epidemiology and Public Health (CIBERESP),Publ Hlth Div Gipuzkoa, San Sebastian 20013, Spain.;Basque Govt, Inst BIOdonostia, San Sebastian 20014, Spain.;CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain.4 aut |
| 700 | 1 | a Arveiler, Dominiqueu University of Strasbourg,Univ Strasbourg, Dept Epidemiol & Publ Hlth EA3430, F-67085 Strasbourg, France.4 aut |
| 700 | 1 | a Aviles-Olmos, Iciaru University College London,UCL Inst Neurol, Sobell Partment Motor Neurosci, London WC1N 3BG, England.4 aut |
| 700 | 1 | a Balkau, Beverleyu University of Paris-Saclay,Washington University in St. Louis,Johns Hopkins University,Queen Mary University,Harvard University,INSERM, Ctr Rech Epidemiol & Sante Populat CESP, F-94807 Villejuif, France.;Univ Paris 11, F-94805 Villejuif, France.,Washington Univ, Sch Med, Div Stat Genom, Dept Genet, St Louis, MO 63108 USA.,Johns Hopkins Univ, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA.,Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, Clin Pharmacol, London EC1M 6BQ, England.,Massachusetts Gen Hosp, Dept Med, Div Gen Internal Med, Boston, MA 02114 USA.;Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA.4 aut |
| 700 | 1 | a Barricarte, Aureliou Health Research Institute of Navarra (IDISNA),CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain.;Navarre Publ Hlth Inst ISPN, Pamplona 31003, Spain.4 aut |
| 700 | 1 | a Barroso, Inesu University of Cambridge,Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England.;Univ Paris 11, F-94805 Villejuif, France.4 aut |
| 700 | 1 | a Garcia, Sara Benllochu University of Cambridge,Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Strangeways Lab, Cambridge CB1 8RN, England.4 aut |
| 700 | 1 | a Bis, Joshua C.u Washington University in St. Louis,University of Cambridge,Univ Washington, Cardiovasc Hlth Res Unit, Dept Med, Seattle, WA 98101 USA.,Univ Cambridge, Canc Res UK Cambridge Inst, Cambridge CB2 0RE, England.;Univ Cambridge, Li Ka Shing Ctr, Dept Oncol, Cambridge CB2 0RE, England.,Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA.4 aut |
| 700 | 1 | a Blankenberg, Stefanu University Medical Center Hamburg-Eppendorf,Univ Heart Ctr Hamburg, Dept Gen & Intervent Cardiol, D-20246 Hamburg, Germany.4 aut |
| 700 | 1 | a Boehnke, Michaelu University of Michigan,Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA.4 aut |
| 700 | 1 | a Boeing, Heineru German Institute of Human Nutrition,German Inst Human Nutr, Potsdam Rehbruecke, D-14558 Nuthetal, Germany.4 aut |
| 700 | 1 | a Boerwinkle, Ericu Baylor College of Medicine,Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Human Genet Ctr, Houston, TX 77025 USA.;Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA.4 aut |
| 700 | 1 | a Borecki, Ingrid B.4 aut |
| 700 | 1 | a Bork-Jensen, Jetteu University of Copenhagen,Univ Copenhagen, NovoNordisk Fdn, Fac Hlth & Med Sci, Ctr Basic Metab Res, DK-2200 Copenhagen, Denmark.4 aut |
| 700 | 1 | a Bowden, Sarahu University of Birmingham,Univ Birmingham, Inst Canc Studies, Canc Res UK Clin Trials Unit, Birmingham B15 2TT, W Midlands, England.4 aut |
| 700 | 1 | a Caldas, Carlos4 aut |
| 700 | 1 | a Caslake, Murielu University of Glasgow,Univ Glasgow, Glasgow G12 8QQ, Lanark, Scotland.4 aut |
| 700 | 1 | a Cupples, L. Adrienne4 aut |
| 700 | 1 | a Cruchaga, Carlos4 aut |
| 700 | 1 | a Czajkowski, Jaceku Washington University in St. Louis,Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63108 USA.;Washington Univ, Sch Med, Ctr Genome Sci & Syst Biol, St Louis, MO 63108 USA.4 aut |
| 700 | 1 | a den Hoed, Marcelu Uppsala universitet,Uppsala University,Molekylär epidemiologi4 aut0 (Swepub:uu)marde358 |
| 700 | 1 | a Dunn, Janet A.u University of Warwick,Univ Warwick, Warwick Clin Trials Unit, Gibbet Hill Rd, Coventry CV4 7AL, W Midlands, England.4 aut |
| 700 | 1 | a Earl, Helena M.u University of Cambridge,Univ Cambridge, Cambridge CB2 0QQ, England.;Cambridge Univ Hosp Natl Hlth Serv Fdn Trust, Natl Inst Hlth Res, Cambridge Biomed Res Ctr, Cambridge CB2 0QQ, England.4 aut |
| 700 | 1 | a Ehret, Georg B.4 aut |
| 700 | 1 | a Ferrannini, Eleu CNR Istituto per le Tecnologie Applicate ai Beni Culturali (CNR-ITABC),CNR, Inst Clin Physiol, I-56124 Pisa, Italy.4 aut |
| 700 | 1 | a Ferrieres, Jeanu National Institute for Health and Medical Research, France,Ctr Hosp Univ CHU Toulouse, Dept Epidemiol, INSERM, UMR 1027, F-31000 Toulouse, France.4 aut |
| 700 | 1 | a Foltynie, Thomasu University College London,UCL Inst Neurol, Sobell Partment Motor Neurosci, London WC1N 3BG, England.4 aut |
| 700 | 1 | a Ford, Ianu University of Glasgow,Univ Glasgow, Glasgow G12 8QQ, Lanark, Scotland.4 aut |
| 700 | 1 | a Forouhi, Nita G.u University of Cambridge,Univ Cambridge, Sch Clin Med, MRC, Epidemiol Unit,Inst Metab Sci, Cambridge Biomedical Campus, Cambridge CB2 0QQ, England.4 aut |
| 700 | 1 | a Gianfagna, Francescou Istituto Neurologico Mediterraneo Neuromed,Univ Insubria, Dept Clin & Expt Med, Res Ctr Epidemiol & Prevent Med, I-21100 Varese, Italy.;IRCCS, Dept Epidemiol & Prevent, Ist Neurol Mediterraneo Neuromed, I-86077 Pozzilli, Italy.4 aut |
| 700 | 1 | a Gonzalez, Carlosu Catalan Institute of Oncology,Catalan Inst Oncol ICO, Barcelona 08908, Spain.4 aut |
| 700 | 1 | a Grioni, Sarau Istituto Nazionale dei Tumori,Epidemiol & Prevent Unit, I-20133 Milan, Italy.4 aut |
| 700 | 1 | a Hiller, Louiseu University of Warwick,Univ Warwick, Warwick Clin Trials Unit, Gibbet Hill Rd, Coventry CV4 7AL, W Midlands, England.4 aut |
| 700 | 1 | a Jansson, Jan-Håkanu Umeå University,Umeå universitet,Medicin,Research Unit, 931 41 Skellefteå, Sweden,Res Unit, S-93141 Skelleftea, Sweden.;Umea Univ, Dept Publ Hlth & Clin Med, S-90185 Umea, Sweden.4 aut0 (Swepub:umu)jaja0006 |
| 700 | 1 | a Jorgensen, Marit E.u University of Southern Denmark,Steno Diabet Ctr, DK-2820 Gentofte, Denmark.;Southern Denmark Univ, Natl Inst Publ Hlth, DK-1353 Odense, Denmark.4 aut |
| 700 | 1 | a Jukema, J. Wouteru Leiden University Medical Centre,Umea Univ, Dept Publ Hlth & Clin Med, S-90185 Umea, Sweden.4 aut |
| 700 | 1 | a Kaaks, Rudolfu German Cancer Research Centre,German Canc Res Ctr, D-69120 Heidelberg, Germany.4 aut |
| 700 | 1 | a Kee, Franku Queen's University Belfast,Queens Univ Belfast, UK Clin Res Collaborat UKCRC, Ctr Excellence Publ Hlth, Belfast BT12 6BJ, Antrim, North Ireland.4 aut |
| 700 | 1 | a Kerrison, Nicola D.u University of Cambridge,Univ Cambridge, Sch Clin Med, MRC, Epidemiol Unit,Inst Metab Sci, Cambridge Biomedical Campus, Cambridge CB2 0QQ, England.4 aut |
| 700 | 1 | a Key, Timothy J.u University of Oxford,Univ Oxford, S Parks Rd, Oxford OX1 2JD, England.4 aut |
| 700 | 1 | a Kontto, Jukkau Finnish National Institute for Health and Welfare,Natl Inst Hlth & Welfare, FI-00271 Helsinki, Finland.4 aut |
| 700 | 1 | a Kote-Jarai, Zsofiau Institute of Cancer Research London,Inst Canc Res, Sutton SM2 5NG, Surrey, England.4 aut |
| 700 | 1 | a Kraja, Aldi T.u Washington University in St. Louis,Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63108 USA.;Washington Univ, Sch Med, Ctr Genome Sci & Syst Biol, St Louis, MO 63108 USA.4 aut |
| 700 | 1 | a Kuulasmaa, Kariu Finnish National Institute for Health and Welfare,Natl Inst Hlth & Welfare, FI-00271 Helsinki, Finland.4 aut |
| 700 | 1 | a Kuusisto, Johannau Kuopio University Hospital,Univ Eastern Finland, Inst Clin Med, Internal Med, FI-70211 Kuopio, Finland.4 aut |
| 700 | 1 | a Linneberg, Allanu University of Copenhagen,Res Ctr Prevent & Hlth, DK-2600 Copenhagen, Denmark.;Rigshosp, Dept Clin Expt, DK-2100 Copenhagen, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, DK-2200 Copenhagen, Denmark.4 aut |
| 700 | 1 | a Liu, Chunyuu NHLBI, Framingham Heart Study, Populat Sci Branch, NIH, Bethesda, MD 20892 USA.4 aut |
| 700 | 1 | a Marenne, Galleu Wellcome Trust Sanger Institute,Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England.4 aut |
| 700 | 1 | a Mohlke, Karen L.4 aut |
| 700 | 1 | a Morris, Andrew P.u University of Oxford,Univ Liverpool, Dept Biostat, Liverpool L69 3GL, Merseyside, England.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England.4 aut |
| 700 | 1 | a Muir, Kennethu University of Warwick,Univ Manchester, Inst Populat Hlth, Ctr Epidemiol, Oxford Rd, Manchester M13 9PT, Lancs, England.;Univ Warwick, Coventry CV4 7AL, W Midlands, England.4 aut |
| 700 | 1 | a Mueller-Nurasyid, Martinau German Centre for Cardiovascular Research,German Res Ctr Environm Hlth, Inst Genet Epidemiol, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany.;Univ Munich, Dept Med 1, D-80336 Munich, Germany.;DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, D-80802 Munich, Germany.4 aut |
| 700 | 1 | a Munroe, Patricia B.4 aut |
| 700 | 1 | a Navarro, Carmenu Murcia Regional Health Council,CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain.;Murcia Reg Hlth Council, Dept Epidemiol, IMIB Arrixaca, Murcia 30008, Spain.4 aut |
| 700 | 1 | a Nielsen, Sune F.u University of Copenhagen,Univ Copenhagen, Copenhagen Univ Hosp, Herlev Hosp, Dept Clin Biochem, DK-2730 Copenhagen, Denmark.4 aut |
| 700 | 1 | a Nilsson, Peter M.u Lund University,Lunds universitet,Medicinska fakulteten,Faculty of Medicine,Lund Univ, S-20502 Malmo, Sweden.4 aut0 (Swepub:lu)medf-pni |
| 700 | 1 | a Nordestgaard, Borge G.u University of Copenhagen,Univ Copenhagen, Copenhagen Univ Hosp, Herlev Hosp, Dept Clin Biochem, DK-2730 Copenhagen, Denmark.4 aut |
| 700 | 1 | a Packard, Chris J.u University of Glasgow,Univ Glasgow, Glasgow G12 8QQ, Lanark, Scotland.4 aut |
| 700 | 1 | a Palli, Domenicou Cancer Research and Prevention Institute (ISPO),Canc Res & Prevent Inst ISPO, I-50141 Florence, Italy.4 aut |
| 700 | 1 | a Panico, Salvatoreu University of Naples Federico II,Univ Naples Federico II, Dipartimento Med Clin & Chirurg, I-80131 Naples, Italy.4 aut |
| 700 | 1 | a Peloso, Gina M.u Helsinki University Central Hospital,Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.;Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA.4 aut |
| 700 | 1 | a Perola, Markusu Finnish National Institute for Health and Welfare,University of Helsinki,Institute for Molecular Medicine Finland (FIMM),Canc Res & Prevent Inst ISPO, I-50141 Florence, Italy.;Univ Helsinki, Inst Mol Med Finland FIMM, FI-00014 Helsinki, Finland.4 aut0 (Swepub:lu)med-mkp |
| 700 | 1 | a Peters, Annetteu DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, D-80802 Munich, Germany.;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, D-85764 Neuherberg, Germany.4 aut |
| 700 | 1 | a Poole, Christopher J.u University Hospital Coventry and Warwickshire,Univ Warwick, Coventry CV4 7AL, W Midlands, England.;Univ Hosp Coventry & Warwickshire, Arden Canc Ctr, Dept Med Oncol, Coventry CV2 2DX, W Midlands, England.4 aut |
| 700 | 1 | a Quiros, J. Ramnu Publ Hlth Directorate, Oviedo 33006, Asturias, Spain.4 aut |
| 700 | 1 | a Rolandsson, Olovu Umeå University,Umeå universitet,Allmänmedicin,Umea Univ, S-90187 Umea, Sweden.4 aut0 (Swepub:umu)olro0005 |
| 700 | 1 | a Sacerdote, Carlottau Human Genetics Foundation (HuGeF),Univ Turin, Citta Salute & Sci Hosp, Unit Canc Epidemiol, I-10126 Turin, Italy.;Ctr Canc Prevent CPO, I-10126 Turin, Italy.;Human Genet Fdn, I-10126 Turin, Italy.4 aut |
| 700 | 1 | a Salomaa, Veikkou Finnish National Institute for Health and Welfare,Natl Inst Hlth & Welfare, FI-00271 Helsinki, Finland.4 aut |
| 700 | 1 | a Sanchez, Mara-Joseu Andalusian School Of Public Health (EASP),CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain.;Univ Granada, Hosp Univ Granada, Inst Invest Biosanitaria Ibs GRANADA, Escuela Andaluza Salud Publ, Granada 18012, Spain.4 aut |
| 700 | 1 | a Sattar, Naveedu University of Glasgow,Univ Glasgow, Glasgow G12 8QQ, Lanark, Scotland.4 aut |
| 700 | 1 | a Sharp, Stephen J.u University of Cambridge,University of Minnesota,Univ Cambridge, Sch Clin Med, MRC, Epidemiol Unit,Inst Metab Sci, Cambridge Biomedical Campus, Cambridge CB2 0QQ, England.,Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN 55455 USA.4 aut |
| 700 | 1 | a Sims, Rebeccau Cardiff University,Cardiff Univ, MRC Ctr, Inst Psychol Med & Clin Neurosci, Cardiff CF24 4HQ, S Glam, Wales.4 aut |
| 700 | 1 | a Slimani, Nadiau International Agency for Research on Cancer, World Health Organization,Int Agcy Res Canc, F-69372 Lyon, France.4 aut |
| 700 | 1 | a Smith, Jennifer A.u University of Michigan,Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.4 aut |
| 700 | 1 | a Thompson, Deborah J.u University of Cambridge,Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Strangeways Lab, Cambridge CB1 8RN, England.4 aut |
| 700 | 1 | a Trompet, Stellau Leiden University Medical Centre,Leiden Univ, Med Ctr, NL-2333 AA Leiden, Netherlands.4 aut |
| 700 | 1 | a Tumino, Rosariou Civic and M.P Arezzo Hospital,ASP Ragusa, Civ MP Arezzo Hosp, Canc Registry & Histopathol Unit, I-97100 Ragusa, Italy.4 aut |
| 700 | 1 | a van der A, Daphne L.4 aut |
| 700 | 1 | a van der Schouw, Yvonne T.u University Medical Center Utrecht,Univ Med Ctr Utrecht, NL-3508 GA Utrecht, Netherlands.4 aut |
| 700 | 1 | a Virtamo, Jarmou Finnish National Institute for Health and Welfare,Natl Inst Hlth & Welfare, FI-00271 Helsinki, Finland.4 aut |
| 700 | 1 | a Walker, Marku University of Newcastle upon Tyne,Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England.4 aut |
| 700 | 1 | a Walter, Klaudiau Wellcome Trust Sanger Institute,Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England.4 aut |
| 700 | 1 | a Abraham, Jean E.u University of Cambridge,Univ Cambridge, Dept Oncol, Strangeways Lab, Ctr Canc Genet Epidemiol, Worts Causeway, Cambridge CB1 8RN, England.4 aut |
| 700 | 1 | a Amundadottir, Laufey T.u National Cancer Institute, USA,NCI, Lab Translat Genom, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.4 aut |
| 700 | 1 | a Aponte, Jennifer L.4 aut |
| 700 | 1 | a Butterworth, Adams.u University of Cambridge,Univ Cambridge, Strangeways Res Lab, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England.4 aut |
| 700 | 1 | a Dupuis, Joseeu Boston University,Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA.4 aut |
| 700 | 1 | a Easton, Douglas F.u University of Cambridge,Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Strangeways Lab, Cambridge CB1 8RN, England.;Univ Cambridge, Dept Oncol, Strangeways Lab, Ctr Canc Genet Epidemiol, Worts Causeway, Cambridge CB1 8RN, England.4 aut |
| 700 | 1 | a Eeles, Rosalind A.u Royal Marsden NHS Foundation Trust,Inst Canc Res, Sutton SM2 5NG, Surrey, England.;Royal Marsden NHS Fdn Trust, London SW3 6JJ, England.;Royal Marsden NHS Fdn Trust, Surrey SW3 6JJ, England.4 aut |
| 700 | 1 | a Erdmann, Jeanetteu British Columbia Children's Hospital,Med Univ Lubeck, Inst Integrat & Expt Genom, D-23562 Lubeck, Germany.4 aut |
| 700 | 1 | a Franks, Paul W.u Umeå University,Lund University,Lunds universitet,Umeå universitet,Medicin,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, SE-205 Malmö, Sweden; Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Genet & Mol Epidemiol Unit, Dept Clin Sci, SE-205 Malmo, Sweden.;Umea Univ, Dept Publ Hlth & Clin Med, S-90185 Umea, Sweden.;Harvard Univ, TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.4 aut0 (Swepub:lu)med-plf |
| 700 | 1 | a Frayling, Timothy M.u University of Exeter,Univ Exeter, Sch Med, Genet Complex Traits, Exeter EX1 2LU, Devon, England.4 aut |
| 700 | 1 | a Hansen, Torbenu University of Copenhagen,Univ Copenhagen, NovoNordisk Fdn, Fac Hlth & Med Sci, Ctr Basic Metab Res, DK-2200 Copenhagen, Denmark.4 aut |
| 700 | 1 | a Howson, Joanna M. M.u University of Cambridge,Univ Cambridge, Strangeways Res Lab, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England.4 aut |
| 700 | 1 | a Jorgensen, Torbenu Aalborg University,Res Ctr Prevent & Hlth, DK-2600 Capital Region, Denmark.;Univ Copenhagen, Inst Hlth Sci, Dept Publ Hlth, DK-1014 Copenhagen, Denmark.;Aalborg Univ, Fac Med, DK-9220 Aalborg, Denmark.4 aut |
| 700 | 1 | a Kooner, Jaspalu Ealing Hospital,Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW3 6LY, England.;Imperial Coll Healthcare NHS Trust, London W2 1NY, England.;Ealing Hosp NHS Trust, Southall UB1 3HW, Middx, England.4 aut |
| 700 | 1 | a Laakso, Markkuu University of Eastern Finland,Univ Kuopio, Dept Med, FI-70211 Kuopio, Finland.4 aut |
| 700 | 1 | a Langenberg, Claudiau Univ Cambridge, Sch Clin Med, MRC, Epidemiol Unit,Inst Metab Sci, Cambridge Biomedical Campus, Cambridge CB2 0QQ, England.4 aut |
| 700 | 1 | a McCarthy, Mark I.u University of Oxford,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab OCDEM, Oxford OX3 7LE, England.4 aut |
| 700 | 1 | a Pankow, James S.4 aut |
| 700 | 1 | a Pedersen, Olufu University of Copenhagen,Univ Copenhagen, NovoNordisk Fdn, Fac Hlth & Med Sci, Ctr Basic Metab Res, DK-2200 Copenhagen, Denmark.4 aut |
| 700 | 1 | a Riboli, Eliou Imperial College London,Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London W2 1PG, England.4 aut |
| 700 | 1 | a Rotter, Jerome I.u Broad Institute,Harbor Univ Calif Los Angeles, Med Ctr, Los Angeles Biomed Res Inst, Inst Translat Genom & Populat Sci, Torrance, CA 90502 USA.4 aut |
| 700 | 1 | a Saleheen, Danishu University of Pennsylvania,Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA.4 aut |
| 700 | 1 | a Samani, Nilesh J.u Glenfield Hospital,Univ Leicester, Glenfield Hosp, Dept Cardiovasc Sci, Leicester LE3 9QP, Leics, England.;Glenfield Hosp, Natl Inst Hlth Res, Leicester Cardiovasc Biomed Res Unit, Leicester LE3 9QP, Leics, England.4 aut |
| 700 | 1 | a Schunkert, Heribertu Technical University of Munich,DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, D-80802 Munich, Germany.;Tech Univ Munich, Deutsch Herzzentrum Munchen, D-80636 Munich, Germany.4 aut |
| 700 | 1 | a Vollenweider, Peteru Lausanne University Hospital,Lausanne Univ Hosp CHUV, Dept Internal Med, Internal Med, BH10-462, CH-1011 Lausanne, Switzerland.4 aut |
| 700 | 1 | a O'Rahilly, Stephenu National Institute for Health Research, United Kingdom,Univ Cambridge, Wellcome Trust MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England.;MRC Metab Dis Unit, Cambridge CB2 0QQ, England.;Natl Inst Hlth Res, Cambridge Biomed Res Ctr, Cambridge CB2 0QQ, England.4 aut |
| 700 | 1 | a Deloukas, Panosu Queen Mary University,Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London EC1M 6BQ, England.4 aut |
| 700 | 1 | a Danesh, Johnu University of Strasbourg,Univ Cambridge, Strangeways Res Lab, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England.;Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England.4 aut |
| 700 | 1 | a Goodarzi, Mark O.u Cedars-Sinai Medical Center,Cedars Sinai Med Ctr, Div Endocrinol Diabet & Metab, Los Angeles, CA 90048 USA.4 aut |
| 700 | 1 | a Kathiresan, Sekaru Massachusetts General Hospital,Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.;Broad Inst Harvard & MIT, Cambridge, MA 02142 USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Cardiol Div, Boston, MA 02114 USA.;Harvard Univ, Sch Med, Boston, MA 02114 USA.4 aut |
| 700 | 1 | a Meigs, James B.4 aut |
| 700 | 1 | a Ehm, Margaret G.u GlaxoSmithKline, PCPS, Genet, Res Triangle Pk, NC 27709 USA.4 aut |
| 700 | 1 | a Wareham, Nicholas J.u University of Cambridge,Univ Cambridge, Sch Clin Med, MRC, Epidemiol Unit,Inst Metab Sci, Cambridge Biomedical Campus, Cambridge CB2 0QQ, England.4 aut |
| 700 | 1 | a Waterworth, Dawn M.u GlaxoSmithKline, PCPS, Genet, Philadelphia, PA 19104 USA.4 aut |
| 710 | 2 | a University of Cambridgeb Univ Cambridge, Sch Clin Med, MRC, Epidemiol Unit,Inst Metab Sci, Cambridge Biomedical Campus, Cambridge CB2 0QQ, England.4 org |
| 773 | 0 | t Science Translational Medicined : American Association for the Advancement of Science (AAAS)g 8:341q 8:341x 1946-6234x 1946-6242 |
| 856 | 4 | u https://europepmc.org/articles/pmc5219001?pdf=render |
| 856 | 4 | u http://dx.doi.org/10.1126/scitranslmed.aad3744y FULLTEXT |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-123447 |
| 856 | 4 8 | u https://doi.org/10.1126/scitranslmed.aad3744 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/5473991d-29f0-4f9e-8d92-a4018d3fbb98 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-299503 |
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