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  • Lallukka, SusannaMinerva Foundation Institute for Medical Research,Helsinki University Central Hospital (författare)

Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • 2017
  • 9 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:1b96c90d-c4e0-4613-abb2-80cba526d8a6
  • https://lup.lub.lu.se/record/1b96c90d-c4e0-4613-abb2-80cba526d8a6URI
  • https://doi.org/10.1160/TH16-09-0716DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Increased liver fat may be caused by insulin resistance and adipose tissue inflammation or by the common I148M variant in PNPLA3 at rs738409, which lacks both of these features. We hypothesised that obesity/insulin resistance rather than liver fat increases circulating coagulation factor activities. We measured plasma prothrombin time (PT, Owren method), activated partial thromboplastin time (APTT), activities of several coagulation factors, VWF:RCo and fibrinogen, and D-dimer concentration in 92 subjects divided into groups based on insulin sensitivity [insulin-resistant (‘IR’) versus insulin-sensitive (‘IS’)] and PNPLA3 genotype (PNPLA3148MM/ MI vs PNPLA3148II). Liver fat content (1H-MRS) was similarly increased in ‘IR’ (13 ± 1%) and PNPLA3148MM/MI (12 ± 2%) as compared to ‘IS’ (6 ± 1%, p<0.05) and PNPLA3148II (8 ± 1%, p<0.05), respectively. FVIII, FIX, FXIII, fibrinogen and VWF:RCo activities were increased, and PT and APTT shortened in ‘IR’ versus ‘IS’, in contrast to these factors being similar between PNPLA3148MM/MI and PNPLA3148II groups. In subjects undergoing a liver biopsy and entirely lacking the I148M variant, insulin-resistant subjects had higher hepatic expression of F8, F9 and FGG than equally obese insulin-sensitive subjects. Expression of pro-inflammatory genes in adipose tissue correlated positively with PT (% of normal), circulating FVIII, FIX, FXI, VWR:RCo and fibrinogen, and expression of anti-inflammatory genes negatively with PT (%), FIX and fibrinogen. We conclude that obesity/insulin resistance rather than an increase in liver fat is associated with a procoagulant plasma profile. This reflects adipose tissue inflammation and increased hepatic production of coagulation factors and their susceptibility for activation.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Luukkonen, Panu K.Helsinki University Central Hospital (författare)
  • Zhou, YouMinerva Foundation Institute for Medical Research (författare)
  • Isokuortti, ElinaHelsinki University Central Hospital (författare)
  • Leivonen, MarjaHelsinki University Central Hospital (författare)
  • Juuti, AnneHelsinki University Central Hospital (författare)
  • Hakkarainen, AnttiHelsinki University Central Hospital (författare)
  • Orho-Melander, MarjuLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)endo-mor (författare)
  • Lundbom, NinaHelsinki University Central Hospital (författare)
  • Olkkonen, Vesa M.Minerva Foundation Institute for Medical Research (författare)
  • Lassila, RiittaHelsinki University Central Hospital (författare)
  • Yki-Järvinen, HanneleHelsinki University Central Hospital (författare)
  • Minerva Foundation Institute for Medical ResearchHelsinki University Central Hospital (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Thrombosis and Haemostasis117:2, s. 286-2940340-6245

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