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Lack of Association...
Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies
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Assimes, Themistocles L. (author)
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Holm, Hilma (author)
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Kathiresan, Sekar (author)
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show more...
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Reilly, Muredach P. (author)
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Thorleifsson, Gudmar (author)
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Voight, Benjamin F. (author)
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Erdmann, Jeanette (author)
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Willenborg, Christina (author)
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Vaidya, Dhananjay (author)
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Xie, Changchun (author)
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Patterson, Chris C. (author)
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Morgan, Thomas M. (author)
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Burnett, Mary Susan (author)
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Li, Mingyao (author)
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Hlatky, Mark A. (author)
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Knowles, Joshua W. (author)
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Thompson, John R. (author)
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Absher, Devin (author)
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Iribarren, Carlos (author)
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Go, Alan (author)
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Fortmann, Stephen P. (author)
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Sidney, Stephen (author)
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Risch, Neil (author)
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Tang, Hua (author)
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Myers, Richard M. (author)
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Berger, Klaus (author)
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Stoll, Monika (author)
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Shah, Svati H. (author)
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Thorgeirsson, Gudmundur (author)
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Andersen, Karl (author)
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Havulinna, Aki S. (author)
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Herrera, J. Enrique (author)
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Faraday, Nauder (author)
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Kim, Yoonhee (author)
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Kral, Brian G. (author)
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Mathias, Rasika A. (author)
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Ruczinski, Ingo (author)
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Suktitipat, Bhoom (author)
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Wilson, Alexander F. (author)
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Yanek, Lisa R. (author)
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Becker, Lewis C. (author)
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Linsel-Nitschke, Patrick (author)
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Lieb, Wolfgang (author)
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Koenig, Inke R. (author)
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Hengstenberg, Christian (author)
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Fischer, Marcus (author)
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Stark, Klaus (author)
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Reinhard, Wibke (author)
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Winogradow, Janina (author)
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Grassl, Martina (author)
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Grosshennig, Anika (author)
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Preuss, Michael (author)
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Schreiber, Stefan (author)
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Wichmann, H-Erich (author)
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Meisinger, Christa (author)
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Yee, Jean (author)
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Friedlander, Yechiel (author)
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Do, Ron (author)
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Meigs, James B. (author)
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Williams, Gordon (author)
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Nathan, David M. (author)
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MacRae, Calum A. (author)
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Qu, Liming (author)
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Wilensky, Robert L. (author)
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Matthai, William H., Jr. (author)
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Qasim, Atif N. (author)
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Hakonarson, Hakon (author)
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Pichard, Augusto D. (author)
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Kent, Kenneth M. (author)
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Satler, Lowell (author)
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Lindsay, Joseph M. (author)
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Waksman, Ron (author)
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Knouff, Christopher W. (author)
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Waterworth, Dawn M. (author)
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Walker, Max C. (author)
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Mooser, Vincent E. (author)
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Marrugat, Jaume (author)
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Lucas, Gavin (author)
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Subirana, Isaac (author)
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Sala, Joan (author)
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Ramos, Rafael (author)
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Martinelli, Nicola (author)
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Olivieri, Oliviero (author)
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Trabetti, Elisabetta (author)
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Malerba, Giovanni (author)
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Pignatti, Pier Franco (author)
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Guiducci, Candace (author)
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Mirel, Daniel (author)
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Parkin, Melissa (author)
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Hirschhorn, Joel N. (author)
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Asselta, Rosanna (author)
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Duga, Stefano (author)
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Musunuru, Kiran (author)
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Daly, Mark J. (author)
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Purcell, Shaun (author)
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Eifert, Sandra (author)
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Braund, Peter S. (author)
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Wright, Benjamin J. (author)
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Balmforth, Anthony J. (author)
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Ball, Stephen G. (author)
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Ouwehand, Willem H. (author)
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Deloukas, Panos (author)
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Scholz, Michael (author)
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Cambien, Francois (author)
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Huge, Andreas (author)
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Scheffold, Thomas (author)
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Salomaa, Veikko (author)
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Girelli, Domenico (author)
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Granger, Christopher B. (author)
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Peltonen, Leena (author)
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McKeown, Pascal P. (author)
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Altshuler, David (author)
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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Devaney, Joseph M. (author)
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Epstein, Stephen E. (author)
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Rader, Daniel J. (author)
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Elosua, Roberto (author)
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Engert, James C. (author)
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Anand, Sonia S. (author)
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Hall, Alistair S. (author)
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Ziegler, Andreas (author)
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O'Donnell, Christopher J. (author)
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Spertus, John A. (author)
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Siscovick, David (author)
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Schwartz, Stephen M. (author)
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Becker, Diane (author)
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Thorsteinsdottir, Unnur (author)
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Stefansson, Kari (author)
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Schunkert, Heribert (author)
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Samani, Nilesh J. (author)
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Quertermous, Thomas (author)
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(creator_code:org_t)
- Elsevier BV, 2010
- 2010
- English.
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In: Journal of the American College of Cardiology. - : Elsevier BV. - 0735-1097. ; 56:19, s. 1552-1563
- Related links:
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http://dx.doi.org/10...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Objectives We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery disease (CAD). Background Recent prospective studies suggest that carriers of the 719Arg allele in KIF6 are at increased risk of clinical CAD compared with noncarriers. Methods The KIF6 Trp719Arg polymorphism (rs20455) was genotyped in 19 case-control studies of nonfatal CAD either as part of a genome-wide association study or in a formal attempt to replicate the initial positive reports. Results A total of 17,000 cases and 39,369 controls of European descent as well as a modest number of South Asians, African Americans, Hispanics, East Asians, and admixed cases and controls were successfully genotyped. None of the 19 studies demonstrated an increased risk of CAD in carriers of the 719Arg allele compared with noncarriers. Regression analyses and fixed-effects meta-analyses ruled out with high degree of confidence an increase of >= 2% in the risk of CAD among European 719Arg carriers. We also observed no increase in the risk of CAD among 719Arg carriers in the subset of Europeans with early-onset disease (younger than 50 years of age for men and younger than 60 years of age for women) compared with similarly aged controls as well as all non-European subgroups. Conclusions The KIF6 Trp719Arg polymorphism was not associated with the risk of clinical CAD in this large replication study. (J Am Coll Cardiol 2010;56:1552-63) (C) 2010 by the American College of Cardiology Foundation
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- myocardial
- kinesin-like protein 6
- coronary artery disease
- KIF6
- polymorphism
- infarction
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Assimes, Themist ...
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Holm, Hilma
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Kathiresan, Seka ...
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Reilly, Muredach ...
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Thorleifsson, Gu ...
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Voight, Benjamin ...
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show more...
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Erdmann, Jeanett ...
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Willenborg, Chri ...
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Vaidya, Dhananja ...
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Xie, Changchun
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Patterson, Chris ...
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Morgan, Thomas M ...
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Burnett, Mary Su ...
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Li, Mingyao
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Hlatky, Mark A.
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Knowles, Joshua ...
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Thompson, John R ...
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Absher, Devin
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Iribarren, Carlo ...
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Go, Alan
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Fortmann, Stephe ...
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Sidney, Stephen
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Risch, Neil
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Tang, Hua
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Myers, Richard M ...
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Berger, Klaus
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Stoll, Monika
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Shah, Svati H.
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Thorgeirsson, Gu ...
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Andersen, Karl
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Havulinna, Aki S ...
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Herrera, J. Enri ...
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Faraday, Nauder
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Kim, Yoonhee
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Kral, Brian G.
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Mathias, Rasika ...
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Ruczinski, Ingo
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Suktitipat, Bhoo ...
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Wilson, Alexande ...
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Yanek, Lisa R.
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Becker, Lewis C.
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Linsel-Nitschke, ...
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Lieb, Wolfgang
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Koenig, Inke R.
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Hengstenberg, Ch ...
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Fischer, Marcus
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Stark, Klaus
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Reinhard, Wibke
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Winogradow, Jani ...
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Grassl, Martina
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Grosshennig, Ani ...
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Preuss, Michael
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Schreiber, Stefa ...
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Wichmann, H-Eric ...
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Meisinger, Chris ...
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Yee, Jean
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Friedlander, Yec ...
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Do, Ron
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Meigs, James B.
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Williams, Gordon
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Nathan, David M.
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MacRae, Calum A.
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Qu, Liming
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Wilensky, Robert ...
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Matthai, William ...
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Qasim, Atif N.
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Hakonarson, Hako ...
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Pichard, Augusto ...
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Kent, Kenneth M.
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Satler, Lowell
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Lindsay, Joseph ...
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Waksman, Ron
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Knouff, Christop ...
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Waterworth, Dawn ...
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Walker, Max C.
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Mooser, Vincent ...
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Marrugat, Jaume
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Lucas, Gavin
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Subirana, Isaac
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Sala, Joan
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Ramos, Rafael
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Martinelli, Nico ...
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Olivieri, Olivie ...
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Trabetti, Elisab ...
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Malerba, Giovann ...
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Pignatti, Pier F ...
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Guiducci, Candac ...
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Mirel, Daniel
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Parkin, Melissa
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Hirschhorn, Joel ...
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Asselta, Rosanna
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Duga, Stefano
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Musunuru, Kiran
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Daly, Mark J.
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Purcell, Shaun
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Eifert, Sandra
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Braund, Peter S.
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Wright, Benjamin ...
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Balmforth, Antho ...
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Ball, Stephen G.
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Ouwehand, Willem ...
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Deloukas, Panos
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Scholz, Michael
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Cambien, Francoi ...
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Huge, Andreas
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Scheffold, Thoma ...
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Salomaa, Veikko
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Girelli, Domenic ...
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Granger, Christo ...
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Peltonen, Leena
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McKeown, Pascal ...
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Altshuler, David
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Melander, Olle
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Devaney, Joseph ...
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Epstein, Stephen ...
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Rader, Daniel J.
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Elosua, Roberto
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Engert, James C.
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Anand, Sonia S.
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Hall, Alistair S ...
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Ziegler, Andreas
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O'Donnell, Chris ...
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Spertus, John A.
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Siscovick, David
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Schwartz, Stephe ...
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Becker, Diane
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Thorsteinsdottir ...
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Stefansson, Kari
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Schunkert, Herib ...
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Samani, Nilesh J ...
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Quertermous, Tho ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Lund University