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Birth Weight, Head ...
Birth Weight, Head Circumference, and Prenatal Exposure to Acrylamide from Maternal Diet : The European Prospective Mother-Child Study (NewGeneris)
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Pedersen, Marie (author)
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- von Stedingk, Hans (author)
- Stockholms universitet,Institutionen för material- och miljökemi (MMK)
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Botsivali, Maria (author)
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Agramunt, Silvia (author)
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Alexander, Jan (author)
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Brunborg, Gunnar (author)
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Chatzi, Leda (author)
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Fleming, Sarah (author)
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Fthenou, Eleni (author)
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Granum, Berit (author)
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Gutzkow, Kristine B. (author)
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Hardie, Laura J. (author)
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Knudsen, Lisbeth E. (author)
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Kyrtopoulos, Soterios A. (author)
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Mendez, Michelle A. (author)
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Merlo, Domenico F. (author)
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Nielsen, Jeanette K. (author)
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- Rydberg, Per (author)
- Stockholms universitet,Institutionen för material- och miljökemi (MMK)
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- Segerback, Dan (author)
- Karolinska Institutet
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Sunyer, Jordi (author)
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Wright, John (author)
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- Törnqvist, Margareta (author)
- Stockholms universitet,Institutionen för material- och miljökemi (MMK)
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Kleinjans, Jos C. (author)
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Kogevinas, Manolis (author)
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(creator_code:org_t)
- Environmental Health Perspectives, 2012
- 2012
- English.
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In: Journal of Environmental Health Perspectives. - : Environmental Health Perspectives. - 0091-6765 .- 1552-9924. ; 120:12, s. 1739-1745
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- BACKGROUND: Acrylamide is a common dietary exposure that crosses the human placenta. It is classified as a probable human carcinogen, and developmental toxicity has been observed in rodents. OBJECTIVES: We examined the associations between prenatal exposure to acrylamide and birth outcomes in a prospective European mother child study. METHODS: Hemoglobin (Hb) adducts of acrylamide and its metabolite glycidamide were measured in cord blood (reflecting cumulated exposure in the last months of pregnancy) from 1,101 singleton pregnant women recruited in Denmark, England, Greece, Norway, and Spain during 2006-2010. Maternal diet was estimated through food-frequency questionnaires. RESULTS: Both acrylamide and glycidamide Hb adducts were associated with a statistically significant reduction in birth weight and head circumference. The estimated difference in birth weight for infants in the highest versus lowest quartile of acrylamide Hb adduct levels after adjusting for gestational age and country was -132 g (95% CI: -207, -56); the corresponding difference for head circumference was -0.33 cm (95% CI: -0.61, -0.06). Findings were similar in infants of nonsmokers, were consistent across countries, and remained after adjustment for Factors associated with reduced birth weight. Maternal consumption of foods rich in acrylamide, such as fried potatoes, was associated with cord blood acrylamide adduct levels and with reduced birth weight. CONCLUSIONS: Dietary exposure to acrylamide was associated with reduced birth weight and head circumference. Consumption of specific foods during pregnancy was associated with higher acrylamide exposure in utero. IF confirmed, these findings suggest that dietary intake of acrylamide should be reduced among pregnant women.
Subject headings
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Keyword
- biomarker
- children
- diet
- intrauterine growth restriction
- in utero exposure
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Pedersen, Marie
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von Stedingk, Ha ...
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Botsivali, Maria
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Agramunt, Silvia
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Alexander, Jan
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Brunborg, Gunnar
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show more...
-
Chatzi, Leda
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Fleming, Sarah
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Fthenou, Eleni
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Granum, Berit
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Gutzkow, Kristin ...
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Hardie, Laura J.
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Knudsen, Lisbeth ...
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Kyrtopoulos, Sot ...
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Mendez, Michelle ...
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Merlo, Domenico ...
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Nielsen, Jeanett ...
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Rydberg, Per
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Segerback, Dan
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Sunyer, Jordi
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Wright, John
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Törnqvist, Marga ...
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Kleinjans, Jos C ...
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Kogevinas, Manol ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Earth and Relate ...
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and Environmental Sc ...
- Articles in the publication
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Journal of Envir ...
- By the university
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Stockholm University
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Karolinska Institutet