(WFRF:(Penninx BWJH)) pers:(Abdellaoui A)
Sökning: (WFRF:(Penninx BWJH)) pers:(Abdellaoui A) > Genetic effects inf...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05945naa a2201417 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:135537117 | |
| 003 | SwePub | |
| 008 | 240818s2017 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1355371172 URI |
| 024 | 7 | a https://doi.org/10.1038/tp.2016.2922 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Bigdeli, TB4 aut |
| 245 | 1 0 | a Genetic effects influencing risk for major depressive disorder in China and Europe |
| 264 | c 2017-03-28 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2017 |
| 520 | a Major depressive disorder (MDD) is a common, complex psychiatric disorder and a leading cause of disability worldwide. Despite twin studies indicating its modest heritability (~30–40%), extensive heterogeneity and a complex genetic architecture have complicated efforts to detect associated genetic risk variants. We combined single-nucleotide polymorphism (SNP) summary statistics from the CONVERGE and PGC studies of MDD, representing 10 502 Chinese (5282 cases and 5220 controls) and 18 663 European (9447 cases and 9215 controls) subjects. We determined the fraction of SNPs displaying consistent directions of effect, assessed the significance of polygenic risk scores and estimated the genetic correlation of MDD across ancestries. Subsequent trans-ancestry meta-analyses combined SNP-level evidence of association. Sign tests and polygenic score profiling weakly support an overlap of SNP effects between East Asian and European populations. We estimated the trans-ancestry genetic correlation of lifetime MDD as 0.33; female-only and recurrent MDD yielded estimates of 0.40 and 0.41, respectively. Common variants downstream of GPHN achieved genome-wide significance by Bayesian trans-ancestry meta-analysis (rs9323497; log10 Bayes Factor=8.08) but failed to replicate in an independent European sample (P=0.911). Gene-set enrichment analyses indicate enrichment of genes involved in neuronal development and axonal trafficking. We successfully demonstrate a partially shared polygenic basis of MDD in East Asian and European populations. Taken together, these findings support a complex etiology for MDD and possible population differences in predisposing genetic factors, with important implications for future genetic studies. | |
| 700 | 1 | a Ripke, S4 aut |
| 700 | 1 | a Peterson, RE4 aut |
| 700 | 1 | a Trzaskowski, M4 aut |
| 700 | 1 | a Bacanu, SA4 aut |
| 700 | 1 | a Abdellaoui, A4 aut |
| 700 | 1 | a Andlauer, TFM4 aut |
| 700 | 1 | a Beekman, ATF4 aut |
| 700 | 1 | a Berger, K4 aut |
| 700 | 1 | a Blackwood, DHR4 aut |
| 700 | 1 | a Boomsma, DI4 aut |
| 700 | 1 | a Breen, G4 aut |
| 700 | 1 | a Buttenschon, HN4 aut |
| 700 | 1 | a Byrne, EM4 aut |
| 700 | 1 | a Cichon, S4 aut |
| 700 | 1 | a Clarke, TK4 aut |
| 700 | 1 | a Couvy-Duchesne, B4 aut |
| 700 | 1 | a Craddock, N4 aut |
| 700 | 1 | a de Geus, EJC4 aut |
| 700 | 1 | a Degenhardt, F4 aut |
| 700 | 1 | a Dunn, EC4 aut |
| 700 | 1 | a Edwards, AC4 aut |
| 700 | 1 | a Fanous, AH4 aut |
| 700 | 1 | a Forstner, AJ4 aut |
| 700 | 1 | a Frank, J4 aut |
| 700 | 1 | a Gill, M4 aut |
| 700 | 1 | a Gordon, SD4 aut |
| 700 | 1 | a Grabe, HJ4 aut |
| 700 | 1 | a Hamilton, SP4 aut |
| 700 | 1 | a Hardiman, O4 aut |
| 700 | 1 | a Hayward, C4 aut |
| 700 | 1 | a Heath, AC4 aut |
| 700 | 1 | a Henders, AK4 aut |
| 700 | 1 | a Herms, S4 aut |
| 700 | 1 | a Hickie, IB4 aut |
| 700 | 1 | a Hoffmann, P4 aut |
| 700 | 1 | a Homuth, G4 aut |
| 700 | 1 | a Hottenga, JJ4 aut |
| 700 | 1 | a Ising, M4 aut |
| 700 | 1 | a Jansen, R4 aut |
| 700 | 1 | a Kloiber, S4 aut |
| 700 | 1 | a Knowles, JA4 aut |
| 700 | 1 | a Lang, M4 aut |
| 700 | 1 | a Li, QS4 aut |
| 700 | 1 | a Lucae, S4 aut |
| 700 | 1 | a MacIntyre, DJ4 aut |
| 700 | 1 | a Madden, PAF4 aut |
| 700 | 1 | a Martin, NG4 aut |
| 700 | 1 | a McGrath, PJ4 aut |
| 700 | 1 | a McGuffin, P4 aut |
| 700 | 1 | a McIntosh, AM4 aut |
| 700 | 1 | a Medland, SE4 aut |
| 700 | 1 | a Mehta, D4 aut |
| 700 | 1 | a Middeldorp, CM4 aut |
| 700 | 1 | a Milaneschi, Y4 aut |
| 700 | 1 | a Montgomery, GW4 aut |
| 700 | 1 | a Mors, O4 aut |
| 700 | 1 | a Muller-Myhsok, B4 aut |
| 700 | 1 | a Nauck, M4 aut |
| 700 | 1 | a Nyholt, DR4 aut |
| 700 | 1 | a Nothen, MM4 aut |
| 700 | 1 | a Owen, MJ4 aut |
| 700 | 1 | a Penninx, BWJH4 aut |
| 700 | 1 | a Pergadia, ML4 aut |
| 700 | 1 | a Perlis, RH4 aut |
| 700 | 1 | a Peyrot, WJ4 aut |
| 700 | 1 | a Porteous, DJ4 aut |
| 700 | 1 | a Potash, JB4 aut |
| 700 | 1 | a Rice, JP4 aut |
| 700 | 1 | a Rietschel, M4 aut |
| 700 | 1 | a Riley, BP4 aut |
| 700 | 1 | a Rivera, M4 aut |
| 700 | 1 | a Schoevers, R4 aut |
| 700 | 1 | a Schulze, TG4 aut |
| 700 | 1 | a Shi, J4 aut |
| 700 | 1 | a Shyn, SI4 aut |
| 700 | 1 | a Smit, JH4 aut |
| 700 | 1 | a Smoller, JW4 aut |
| 700 | 1 | a Streit, F4 aut |
| 700 | 1 | a Strohmaier, J4 aut |
| 700 | 1 | a Teumer, A4 aut |
| 700 | 1 | a Treutlein, J4 aut |
| 700 | 1 | a Van der Auwera, S4 aut |
| 700 | 1 | a van Grootheest, G4 aut |
| 700 | 1 | a van Hemert, AM4 aut |
| 700 | 1 | a Volzke, H4 aut |
| 700 | 1 | a Webb, BT4 aut |
| 700 | 1 | a Weissman, MM4 aut |
| 700 | 1 | a Wellmann, J4 aut |
| 700 | 1 | a Willemsen, G4 aut |
| 700 | 1 | a Witt, SH4 aut |
| 700 | 1 | a Levinson, DF4 aut |
| 700 | 1 | a Lewis, CM4 aut |
| 700 | 1 | a Wray, NR4 aut |
| 700 | 1 | a Flint, J4 aut |
| 700 | 1 | a Sullivan, PFu Karolinska Institutet4 aut |
| 700 | 1 | a Kendler, KS4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Translational psychiatryd : Springer Science and Business Media LLCg 7:3, s. e1074-q 7:3<e1074-x 2158-3188 |
| 856 | 4 | u https://www.nature.com/articles/tp2016292.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:135537117 |
| 856 | 4 8 | u https://doi.org/10.1038/tp.2016.292 |
Hitta via bibliotek
- Translational psychiatry (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
Hitta mer i SwePub
- Av författaren/redakt...
- Bigdeli, TB
- Ripke, S
- Peterson, RE
- Trzaskowski, M
- Bacanu, SA
- Abdellaoui, A
- visa fler...
- Andlauer, TFM
- Beekman, ATF
- Berger, K
- Blackwood, DHR
- Boomsma, DI
- Breen, G
- Buttenschon, HN
- Byrne, EM
- Cichon, S
- Clarke, TK
- Couvy-Duchesne, ...
- Craddock, N
- de Geus, EJC
- Degenhardt, F
- Dunn, EC
- Edwards, AC
- Fanous, AH
- Forstner, AJ
- Frank, J
- Gill, M
- Gordon, SD
- Grabe, HJ
- Hamilton, SP
- Hardiman, O
- Hayward, C
- Heath, AC
- Henders, AK
- Herms, S
- Hickie, IB
- Hoffmann, P
- Homuth, G
- Hottenga, JJ
- Ising, M
- Jansen, R
- Kloiber, S
- Knowles, JA
- Lang, M
- Li, QS
- Lucae, S
- MacIntyre, DJ
- Madden, PAF
- Martin, NG
- McGrath, PJ
- McGuffin, P
- McIntosh, AM
- Medland, SE
- Mehta, D
- Middeldorp, CM
- Milaneschi, Y
- Montgomery, GW
- Mors, O
- Muller-Myhsok, B
- Nauck, M
- Nyholt, DR
- Nothen, MM
- Owen, MJ
- Penninx, BWJH
- Pergadia, ML
- Perlis, RH
- Peyrot, WJ
- Porteous, DJ
- Potash, JB
- Rice, JP
- Rietschel, M
- Riley, BP
- Rivera, M
- Schoevers, R
- Schulze, TG
- Shi, J
- Shyn, SI
- Smit, JH
- Smoller, JW
- Streit, F
- Strohmaier, J
- Teumer, A
- Treutlein, J
- Van der Auwera, ...
- van Grootheest, ...
- van Hemert, AM
- Volzke, H
- Webb, BT
- Weissman, MM
- Wellmann, J
- Willemsen, G
- Witt, SH
- Levinson, DF
- Lewis, CM
- Wray, NR
- Flint, J
- Sullivan, PF
- Kendler, KS
- visa färre...
- Artiklar i publikationen
- Translational ps ...
- Av lärosätet
- Karolinska Institutet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
