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Sökning: (WFRF:(Renlund Henrik 1979 )) > Effects of early my...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005451naa a2200505 4500
001oai:DiVA.org:uu-483781
003SwePub
008220907s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4837812 URI
0247 a https://doi.org/10.1093/ehjacc/zuac0202 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Batra, Goravu Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)gorba357
2451 0a Effects of early myocardial reperfusion and perfusion on myocardial necrosis/dysfunction and inflammation in patients with ST-segment and non-ST-segment elevation acute coronary syndrome :b results from the PLATelet inhibition and patients Outcomes (PLATO) trial
264 c 2022-02-25
264 1b Oxford University Press,c 2022
338 a electronic2 rdacarrier
520 a Aims Restoration of myocardial blood flow and perfusion during percutaneous coronary intervention (PCI) measured using Thrombolysis in Myocardial Infarction (TIMI) flow grade (TFG) and perfusion grade (TMPG) is associated with improved outcomes in acute coronary syndrome (ACS). Associations between TFG/TMPG and changes in biomarkers reflecting myocardial damage/dysfunction and inflammation is unknown. Methods and results Among 2606 patients included, TFG was evaluated in 2198 and TMPG in 1874 with ST-segment elevation myocardial infarction (STEMI) or non-ST-segment ACS (NSTE-ACS). Biomarkers reflecting myocardial necrosis [troponin T (TnT)], myocardial dysfunction [N-terminal prohormone brain natriuretic peptide (NT-proBNP)], inflammation [interleukin-6 (IL-6) and C-reactive protein (CRP)], and oxidative stress/ageing/inflammation [growth differentiation factor-15 (GDF-15)] were measured at baseline, discharge, and 1- and 6-month post-randomization. Associations between TFG/TMPG and changes in biomarker levels were evaluated using the Mann-Whitney-Wilcoxon signed test. In total, 1423 (54.6%) patients had STEMI and 1183 (45.4%) NSTE-ACS. Complete reperfusion after PCI with TFG = 3 was achieved in 1110 (85.3%) with STEMI and in 793 (88.5%) with NSTE-ACS. Normal myocardial perfusion with TMPG = 3 was achieved in 475 (41.6%) with STEMI and in 396 (54.0%) with NSTE-ACS. Levels of TnT, NT-proBNP, IL-6, CRP, and GDF-15 were substantially lower at discharge in patients with complete vs. incomplete TFG and STEMI (P < 0.01). This pattern was not observed for patients with NSTE-ACS. Patients with normal vs. abnormal TMPG and NSTE-ACS had lower levels of NT-proBNP at discharge (P = 0.01). Conclusions Successful restoration of epicardial blood flow in STEMI was associated with less myocardial necrosis/dysfunction and inflammation. Attainment of normal myocardial perfusion was associated with less myocardial dysfunction in NSTE-ACS.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a Acute coronary syndrome
653 a Percutaneous coronary intervention
653 a TIMI flow grade
653 a TIMI myocardial perfusion grade
653 a Biomarkers
7001 a Renlund, Henrik,d 1979-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)henre358
7001 a Kunadian, Vijayu Newcastle Univ, Fac Med Sci, Translat & Clin Res Inst, Newcastle Upon Tyne, Tyne & Wear, England.;Newcastle Upon Tyne Hosp NHS Fdn Trust, Freeman Hosp, Cardiothorac Ctr, Newcastle Upon Tyne, Tyne & Wear, England.4 aut
7001 a James, Stefan K.,d 1964-u Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)stjam367
7001 a Storey, Robert F.u Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield, S Yorkshire, England.4 aut
7001 a Steg, P. Gabrielu Univ Paris, Hop Bichat, AP HP, French Alliance Cardiovasc Trials, Paris, France.;INSERM, U1148, Paris, France.4 aut
7001 a Katus, Hugo A.u Univ Klinikum Heidelberg, Med Klin, Heidelberg, Germany.4 aut
7001 a Harrington, Robert A.u Stanford Univ, Dept Med, Stanford, CA 94305 USA. Beth Israel Deaconess Med Ctr, Harvard Med Sch, Dept Med, Cardiovasc Div, Boston, MA USA. Grochowski Hosp, Ctr Postgrad Med Educ, Dept Cardiol, Warsaw, Poland.4 aut
7001 a Gibson, C. Michaelu Uppsala universitet,Klinisk kemi4 aut
7001 a Budaj, Andrzeju Center of Postgraduate Medical Education, Grochowski Hospital, Warsaw, Poland4 aut
7001 a Siegbahn, Agneta,d 1947-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)agsie424
7001 a Wallentin, Lars,d 1943-u Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)larswall
7102 a Uppsala universitetb Uppsala kliniska forskningscentrum (UCR)4 org
7730 t European Heart Journald : Oxford University Pressg 11:4, s. 336-349q 11:4<336-349x 2048-8726x 2048-8734
8564 u https://doi.org/10.1093/ehjacc/zuac020y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1693666/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-483781
8564 8u https://doi.org/10.1093/ehjacc/zuac020

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