(WFRF:(Siscovick David)) lar1:(gu)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06982naa a2201165 4500 | |
| 001 | oai:gup.ub.gu.se/123622 | |
| 003 | SwePub | |
| 008 | 240528s2010 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/1236222 URI |
| 024 | 7 | a https://doi.org/10.1016/S0140-6736(10)60588-02 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Wang, Thomas J4 aut |
| 245 | 1 0 | a Common genetic determinants of vitamin D insufficiency: a genome-wide association study. |
| 264 | 1 | c 2010 |
| 520 | a BACKGROUND: Vitamin D is crucial for maintenance of musculoskeletal health, and might also have a role in extraskeletal tissues. Determinants of circulating 25-hydroxyvitamin D concentrations include sun exposure and diet, but high heritability suggests that genetic factors could also play a part. We aimed to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency. METHODS: We undertook a genome-wide association study of 25-hydroxyvitamin D concentrations in 33 996 individuals of European descent from 15 cohorts. Five epidemiological cohorts were designated as discovery cohorts (n=16 125), five as in-silico replication cohorts (n=9367), and five as de-novo replication cohorts (n=8504). 25-hydroxyvitamin D concentrations were measured by radioimmunoassay, chemiluminescent assay, ELISA, or mass spectrometry. Vitamin D insufficiency was defined as concentrations lower than 75 nmol/L or 50 nmol/L. We combined results of genome-wide analyses across cohorts using Z-score-weighted meta-analysis. Genotype scores were constructed for confirmed variants. FINDINGS: Variants at three loci reached genome-wide significance in discovery cohorts for association with 25-hydroxyvitamin D concentrations, and were confirmed in replication cohorts: 4p12 (overall p=1.9x10(-109) for rs2282679, in GC); 11q12 (p=2.1x10(-27) for rs12785878, near DHCR7); and 11p15 (p=3.3x10(-20) for rs10741657, near CYP2R1). Variants at an additional locus (20q13, CYP24A1) were genome-wide significant in the pooled sample (p=6.0x10(-10) for rs6013897). Participants with a genotype score (combining the three confirmed variants) in the highest quartile were at increased risk of having 25-hydroxyvitamin D concentrations lower than 75 nmol/L (OR 2.47, 95% CI 2.20-2.78, p=2.3x10(-48)) or lower than 50 nmol/L (1.92, 1.70-2.16, p=1.0x10(-26)) compared with those in the lowest quartile. INTERPRETATION: Variants near genes involved in cholesterol synthesis, hydroxylation, and vitamin D transport affect vitamin D status. Genetic variation at these loci identifies individuals who have substantially raised risk of vitamin D insufficiency. FUNDING: Full funding sources listed at end of paper (see Acknowledgments). | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 700 | 1 | a Zhang, Feng4 aut |
| 700 | 1 | a Richards, J Brent4 aut |
| 700 | 1 | a Kestenbaum, Bryan4 aut |
| 700 | 1 | a van Meurs, Joyce B4 aut |
| 700 | 1 | a Berry, Diane4 aut |
| 700 | 1 | a Kiel, Douglas P4 aut |
| 700 | 1 | a Streeten, Elizabeth A4 aut |
| 700 | 1 | a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine4 aut0 (Swepub:gu)xohlcl |
| 700 | 1 | a Koller, Daniel L4 aut |
| 700 | 1 | a Peltonen, Leena4 aut |
| 700 | 1 | a Cooper, Jason D4 aut |
| 700 | 1 | a O'Reilly, Paul F4 aut |
| 700 | 1 | a Houston, Denise K4 aut |
| 700 | 1 | a Glazer, Nicole L4 aut |
| 700 | 1 | a Vandenput, Liesbeth,d 1974u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine4 aut0 (Swepub:gu)xvanli |
| 700 | 1 | a Peacock, Munro4 aut |
| 700 | 1 | a Shi, Julia4 aut |
| 700 | 1 | a Rivadeneira, Fernando4 aut |
| 700 | 1 | a McCarthy, Mark I4 aut |
| 700 | 1 | a Anneli, Pouta4 aut |
| 700 | 1 | a de Boer, Ian H4 aut |
| 700 | 1 | a Mangino, Massimo4 aut |
| 700 | 1 | a Kato, Bernet4 aut |
| 700 | 1 | a Smyth, Deborah J4 aut |
| 700 | 1 | a Booth, Sarah L4 aut |
| 700 | 1 | a Jacques, Paul F4 aut |
| 700 | 1 | a Burke, Greg L4 aut |
| 700 | 1 | a Goodarzi, Mark4 aut |
| 700 | 1 | a Cheung, Ching-Lung4 aut |
| 700 | 1 | a Wolf, Myles4 aut |
| 700 | 1 | a Rice, Kenneth4 aut |
| 700 | 1 | a Goltzman, David4 aut |
| 700 | 1 | a Hidiroglou, Nick4 aut |
| 700 | 1 | a Ladouceur, Martin4 aut |
| 700 | 1 | a Wareham, Nicholas J4 aut |
| 700 | 1 | a Hocking, Lynne J4 aut |
| 700 | 1 | a Hart, Deborah4 aut |
| 700 | 1 | a Arden, Nigel K4 aut |
| 700 | 1 | a Cooper, Cyrus4 aut |
| 700 | 1 | a Malik, Suneil4 aut |
| 700 | 1 | a Fraser, William D4 aut |
| 700 | 1 | a Hartikainen, Anna-Liisa4 aut |
| 700 | 1 | a Zhai, Guangju4 aut |
| 700 | 1 | a Macdonald, Helen M4 aut |
| 700 | 1 | a Forouhi, Nita G4 aut |
| 700 | 1 | a Loos, Ruth Jf4 aut |
| 700 | 1 | a Reid, David M4 aut |
| 700 | 1 | a Hakim, Alan4 aut |
| 700 | 1 | a Dennison, Elaine4 aut |
| 700 | 1 | a Liu, Yongmei4 aut |
| 700 | 1 | a Power, Chris4 aut |
| 700 | 1 | a Stevens, Helen E4 aut |
| 700 | 1 | a Jaana, Laitinen4 aut |
| 700 | 1 | a Vasan, Ramachandran S4 aut |
| 700 | 1 | a Soranzo, Nicole4 aut |
| 700 | 1 | a Bojunga, Jörg4 aut |
| 700 | 1 | a Psaty, Bruce M4 aut |
| 700 | 1 | a Lorentzon, Mattias,d 1970u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine4 aut0 (Swepub:gu)xlomat |
| 700 | 1 | a Foroud, Tatiana4 aut |
| 700 | 1 | a Harris, Tamara B4 aut |
| 700 | 1 | a Hofman, Albert4 aut |
| 700 | 1 | a Jansson, John-Olov,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xjanjo |
| 700 | 1 | a Cauley, Jane A4 aut |
| 700 | 1 | a Uitterlinden, Andre G4 aut |
| 700 | 1 | a Gibson, Quince4 aut |
| 700 | 1 | a Järvelin, Marjo-Riitta4 aut |
| 700 | 1 | a Karasik, David4 aut |
| 700 | 1 | a Siscovick, David S4 aut |
| 700 | 1 | a Econs, Michael J4 aut |
| 700 | 1 | a Kritchevsky, Stephen B4 aut |
| 700 | 1 | a Florez, Jose C4 aut |
| 700 | 1 | a Todd, John A4 aut |
| 700 | 1 | a Dupuis, Josee4 aut |
| 700 | 1 | a Hyppönen, Elina4 aut |
| 700 | 1 | a Spector, Timothy D4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för invärtesmedicin4 org |
| 773 | 0 | t Lancetg 376:9736, s. 180-8q 376:9736<180-8x 1474-547X |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/123622 |
| 856 | 4 8 | u https://doi.org/10.1016/S0140-6736(10)60588-0 |
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