Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study.

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Fältnamn	Indikatorer	Metadata
000		09855naa a2201621 4500
001		oai:gup.ub.gu.se/210425
003		SwePub
008		240528s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:de0d4504-5573-4d84-9d35-0885eba43412
009		oai:DiVA.org:uu-233264
024	7	a https://gup.ub.gu.se/publication/2104252 URI
024	7	a https://doi.org/10.1016/S2213-8587(14)70113-52 DOI
024	7	a https://lup.lub.lu.se/record/45235502 URI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2332642 URI
040		a (SwePub)gud (SwePub)lud (SwePub)uu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Vimaleswaran, Karani S4 aut
245	1 0	a Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study.
264	1	c 2014
520		a Background Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation approach to test whether 25(OH)D concentration is causally associated with blood pressure and hypertension risk. Methods In this mendelian randomisation study, we generated an allele score (25[OH]D synthesis score) based on variants of genes that affect 25(OH)D synthesis or substrate availability (CYP2R1 and DHCR7), which we used as a proxy for 25(OH)D concentration. We meta-analysed data for up to 108173 individuals from 35 studies in the D-CarDia collaboration to investigate associations between the allele score and blood pressure measurements. We complemented these analyses with previously published summary statistics from the International Consortium on Blood Pressure (ICBP), the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and the Global Blood Pressure Genetics (Global BPGen) consortium. Findings In phenotypic analyses (up to n=49363), increased 25(OH)D concentration was associated with decreased systolic blood pressure (β per 10% increase, −0·12 mm Hg, 95% CI −0·20 to −0·04; p=0·003) and reduced odds of hypertension (odds ratio [OR] 0·98, 95% CI 0·97–0·99; p=0·0003), but not with decreased diastolic blood pressure (β per 10% increase, −0·02 mm Hg, −0·08 to 0·03; p=0·37). In meta-analyses in which we combined data from D-CarDia and the ICBP (n=146581, after exclusion of overlapping studies), each 25(OH)D-increasing allele of the synthesis score was associated with a change of −0·10 mm Hg in systolic blood pressure (−0·21 to −0·0001; p=0·0498) and a change of −0·08 mm Hg in diastolic blood pressure (−0·15 to −0·02; p=0·01). When D-CarDia and consortia data for hypertension were meta-analysed together (n=142255), the synthesis score was associated with a reduced odds of hypertension (OR per allele, 0·98, 0·96–0·99; p=0·001). In instrumental variable analysis, each 10% increase in genetically instrumented 25(OH)D concentration was associated with a change of −0·29 mm Hg in diastolic blood pressure (−0·52 to −0·07; p=0·01), a change of −0·37 mm Hg in systolic blood pressure (−0·73 to 0·003; p=0·052), and an 8·1% decreased odds of hypertension (OR 0·92, 0·87–0·97; p=0·002). Interpretation Increased plasma concentrations of 25(OH)D might reduce the risk of hypertension. This finding warrants further investigation in an independent, similarly powered study.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
700	1	a Cavadino, Alana4 aut
700	1	a Berry, Diane J4 aut
700	1	a Jorde, Rolf4 aut
700	1	a Dieffenbach, Aida Karina4 aut
700	1	a Lu, Chen4 aut
700	1	a Alves, Alexessander Couto4 aut
700	1	a Heerspink, Hiddo J Lambers4 aut
700	1	a Tikkanen, Emmi4 aut
700	1	a Eriksson, Joelu Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research4 aut0 (Swepub:gu)xerjoe
700	1	a Wong, Andrew4 aut
700	1	a Mangino, Massimo4 aut
700	1	a Jablonski, Kathleen A4 aut
700	1	a Nolte, Ilja M4 aut
700	1	a Houston, Denise K4 aut
700	1	a Ahluwalia, Tarunveer Singh4 aut
700	1	a van der Most, Peter J4 aut
700	1	a Pasko, Dorota4 aut
700	1	a Zgaga, Lina4 aut
700	1	a Thiering, Elisabeth4 aut
700	1	a Vitart, Veronique4 aut
700	1	a Fraser, Ross M4 aut
700	1	a Huffman, Jennifer E4 aut
700	1	a de Boer, Rudolf A4 aut
700	1	a Schöttker, Ben4 aut
700	1	a Saum, Kai-Uwe4 aut
700	1	a McCarthy, Mark I4 aut
700	1	a Dupuis, Josée4 aut
700	1	a Herzig, Karl-Heinz4 aut
700	1	a Sebert, Sylvain4 aut
700	1	a Pouta, Anneli4 aut
700	1	a Laitinen, Jaana4 aut
700	1	a Kleber, Marcus E4 aut
700	1	a Navis, Gerjan4 aut
700	1	a Lorentzon, Mattias,d 1970u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research4 aut0 (Swepub:gu)xlomat
700	1	a Jameson, Karen4 aut
700	1	a Arden, Nigel4 aut
700	1	a Cooper, Jackie A4 aut
700	1	a Acharya, Jayshree4 aut
700	1	a Hardy, Rebecca4 aut
700	1	a Raitakari, Olli4 aut
700	1	a Ripatti, Samuli4 aut
700	1	a Billings, Liana K4 aut
700	1	a Lahti, Jari4 aut
700	1	a Osmond, Clive4 aut
700	1	a Penninx, Brenda W4 aut
700	1	a Rejnmark, Lars4 aut
700	1	a Lohman, Kurt K4 aut
700	1	a Paternoster, Lavinia4 aut
700	1	a Stolk, Ronald P4 aut
700	1	a Hernandez, Dena G4 aut
700	1	a Byberg, Liisau Uppsala universitet,Ortopedi4 aut0 (Swepub:uu)liisbybe
700	1	a Hagström, Emilu Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)emhag677
700	1	a Melhus, Håkanu Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Klinisk farmakogenomik och osteoporos4 aut0 (Swepub:uu)hakamelh
700	1	a Ingelsson, Eriku Uppsala universitet,Molekylär epidemiologi,Uppsala kliniska forskningscentrum (UCR),Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)ering425
700	1	a Mellström, Dan,d 1945u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research4 aut0 (Swepub:gu)xmelda
700	1	a Ljunggren, Östenu Uppsala universitet,Endokrinologi och mineralmetabolism,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)osteljun
700	1	a Tzoulaki, Ioanna4 aut
700	1	a McLachlan, Stela4 aut
700	1	a Theodoratou, Evropi4 aut
700	1	a Tiesler, Carla M T4 aut
700	1	a Jula, Antti4 aut
700	1	a Navarro, Pau4 aut
700	1	a Wright, Alan F4 aut
700	1	a Polasek, Ozren4 aut
700	1	a Wilson, James F4 aut
700	1	a Rudan, Igor4 aut
700	1	a Salomaa, Veikko4 aut
700	1	a Heinrich, Joachim4 aut
700	1	a Campbell, Harry4 aut
700	1	a Price, Jacqueline F4 aut
700	1	a Karlsson, Magnusu Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups4 aut0 (Swepub:lu)orto-mka
700	1	a Lind, Larsu Uppsala universitet,Kardiovaskulär epidemiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)larslind
700	1	a Michaëlsson, Karlu Uppsala universitet,Ortopedi4 aut0 (Swepub:uu)karlmich
700	1	a Bandinelli, Stefania4 aut
700	1	a Frayling, Timothy M4 aut
700	1	a Hartman, Catharina A4 aut
700	1	a Sørensen, Thorkild I A4 aut
700	1	a Kritchevsky, Stephen B4 aut
700	1	a Langdahl, Bente Lomholt4 aut
700	1	a Eriksson, Johan G4 aut
700	1	a Florez, Jose C4 aut
700	1	a Spector, Tim D4 aut
700	1	a Lehtimäki, Terho4 aut
700	1	a Kuh, Diana4 aut
700	1	a Humphries, Steve E4 aut
700	1	a Cooper, Cyrus4 aut
700	1	a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research4 aut0 (Swepub:gu)xohlcl
700	1	a März, Winfried4 aut
700	1	a de Borst, Martin H4 aut
700	1	a Kumari, Meena4 aut
700	1	a Kivimaki, Mika4 aut
700	1	a Wang, Thomas J4 aut
700	1	a Power, Chris4 aut
700	1	a Brenner, Hermann4 aut
700	1	a Grimnes, Guri4 aut
700	1	a van der Harst, Pim4 aut
700	1	a Snieder, Harold4 aut
700	1	a Hingorani, Aroon D4 aut
700	1	a Pilz, Stefan4 aut
700	1	a Whittaker, John C4 aut
700	1	a Järvelin, Marjo-Riitta4 aut
700	1	a Hyppönen, Elina4 aut
710	2	a Göteborgs universitetb Centre for Bone and Arthritis Research4 org
773	0	t The lancet. Diabetes & endocrinologyg 2:9, s. 719-29q 2:9<719-29x 2213-8595x 2213-8587
856	4	u https://portal.research.lu.se/files/1604694/5265854x primaryx freey FULLTEXT
856	4	u http://www.ncbi.nlm.nih.gov/pubmed/24974252?dopt=Abstracty FULLTEXT
856	4	u http://dx.doi.org/10.1016/S2213-8587(14)70113-5y FULLTEXT
856	4	u https://doi.org/10.1016/S2213-8587(14)70113-5y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:751534/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4 8	u https://gup.ub.gu.se/publication/210425
856	4 8	u https://doi.org/10.1016/S2213-8587(14)70113-5
856	4 8	u https://lup.lub.lu.se/record/4523550
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-233264

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