Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

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Fältnamn	Indikatorer	Metadata
000		09986naa a2202269 4500
001		oai:DiVA.org:uu-131527
003		SwePub
008		101004s2010 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:7c7e3cf9-9e3d-4371-9139-74000ff2b213
009		oai:prod.swepub.kib.ki.se:120004916
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1315272 URI
024	7	a https://doi.org/10.1038/ng.5212 DOI
024	7	a https://lup.lub.lu.se/record/15698742 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1200049162 URI
040		a (SwePub)uud (SwePub)lud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Saxena, Richa4 aut
245	1 0	a Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
264		c 2010-01-17
264	1	b Springer Science and Business Media LLC,c 2010
338		a print2 rdacarrier
520		a Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance used in the diagnosis of type 2 diabetes. We report a meta-analysis of nine genome-wide association studies (n = 15,234 nondiabetic individuals) and a follow-up of 29 independent loci (n = 6,958–30,620). We identify variants at the GIPR locus associated with 2-h glucose level (rs10423928, β (s.e.m.) = 0.09 (0.01) mmol/l per A allele, P = 2.0 × 10−15). The GIPR A-allele carriers also showed decreased insulin secretion (n = 22,492; insulinogenic index, P = 1.0 × 10−17; ratio of insulin to glucose area under the curve, P = 1.3 × 10−16) and diminished incretin effect (n = 804; P = 4.3 × 10−4). We also identified variants at ADCY5 (rs2877716, P = 4.2 × 10−16), VPS13C (rs17271305, P = 4.1 × 10−8), GCKR (rs1260326, P = 7.1 × 10−11) and TCF7L2 (rs7903146, P = 4.2 × 10−10) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies (n = 35,869 cases, 89,798 controls, OR = 1.12, 95% CI 1.09–1.15, P = 4.8 × 10−18).
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Annan klinisk medicin0 (SwePub)302992 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Other Clinical Medicine0 (SwePub)302992 hsv//eng
653		a MEDICINE
653		a MEDICIN
700	1	a Hivert, Marie-France4 aut
700	1	a Langenberg, Claudia4 aut
700	1	a Tanaka, Toshiko4 aut
700	1	a Pankow, James S4 aut
700	1	a Vollenweider, Peter4 aut
700	1	a Lyssenko, Valeriyau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-vly
700	1	a Bouatia-Naji, Nabila4 aut
700	1	a Dupuis, Josée4 aut
700	1	a Jackson, Anne U4 aut
700	1	a Kao, W H Linda4 aut
700	1	a Li, Man4 aut
700	1	a Glazer, Nicole L4 aut
700	1	a Manning, Alisa K4 aut
700	1	a Luan, Jian'an4 aut
700	1	a Stringham, Heather M4 aut
700	1	a Prokopenko, Inga4 aut
700	1	a Johnson, Toby4 aut
700	1	a Grarup, Niels4 aut
700	1	a Boesgaard, Trine W4 aut
700	1	a Lecoeur, Cécile4 aut
700	1	a Shrader, Peter4 aut
700	1	a O'Connell, Jeffrey4 aut
700	1	a Ingelsson, Eriku Karolinska Institutet,Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)ering425
700	1	a Couper, David J4 aut
700	1	a Rice, Kenneth4 aut
700	1	a Song, Kijoung4 aut
700	1	a Andreasen, Camilla H4 aut
700	1	a Dina, Christian4 aut
700	1	a Köttgen, Anna4 aut
700	1	a Le Bacquer, Olivier4 aut
700	1	a Pattou, François4 aut
700	1	a Taneera, Jalalu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)stem-jta
700	1	a Steinthorsdottir, Valgerdur4 aut
700	1	a Rybin, Denis4 aut
700	1	a Ardlie, Kristin4 aut
700	1	a Sampson, Michael4 aut
700	1	a Qi, Lu4 aut
700	1	a van Hoek, Mandy4 aut
700	1	a Weedon, Michael N4 aut
700	1	a Aulchenko, Yurii S4 aut
700	1	a Voight, Benjamin F4 aut
700	1	a Grallert, Harald4 aut
700	1	a Balkau, Beverley4 aut
700	1	a Bergman, Richard N4 aut
700	1	a Bielinski, Suzette J4 aut
700	1	a Bonnefond, Amelie4 aut
700	1	a Bonnycastle, Lori L4 aut
700	1	a Borch-Johnsen, Knut4 aut
700	1	a Böttcher, Yvonne4 aut
700	1	a Brunner, Eric4 aut
700	1	a Buchanan, Thomas A4 aut
700	1	a Bumpstead, Suzannah J4 aut
700	1	a Cavalcanti-Proença, Christine4 aut
700	1	a Charpentier, Guillaume4 aut
700	1	a Chen, Yii-Der Ida4 aut
700	1	a Chines, Peter S4 aut
700	1	a Collins, Francis S4 aut
700	1	a Cornelis, Marilyn4 aut
700	1	a J Crawford, Gabriel4 aut
700	1	a Delplanque, Jerome4 aut
700	1	a Doney, Alex4 aut
700	1	a Egan, Josephine M4 aut
700	1	a Erdos, Michael R4 aut
700	1	a Firmann, Mathieu4 aut
700	1	a Forouhi, Nita G4 aut
700	1	a Fox, Caroline S4 aut
700	1	a Goodarzi, Mark O4 aut
700	1	a Graessler, Jürgen4 aut
700	1	a Hingorani, Aroon4 aut
700	1	a Isomaa, Bo4 aut
700	1	a Jørgensen, Torben4 aut
700	1	a Kivimaki, Mika4 aut
700	1	a Kovacs, Peter4 aut
700	1	a Krohn, Knut4 aut
700	1	a Kumari, Meena4 aut
700	1	a Lauritzen, Torsten4 aut
700	1	a Lévy-Marchal, Claire4 aut
700	1	a Mayor, Vladimir4 aut
700	1	a McAteer, Jarred B4 aut
700	1	a Meyre, David4 aut
700	1	a Mitchell, Braxton D4 aut
700	1	a Mohlke, Karen L4 aut
700	1	a Morken, Mario A4 aut
700	1	a Narisu, Narisu4 aut
700	1	a Palmer, Colin N A4 aut
700	1	a Pakyz, Ruth4 aut
700	1	a Pascoe, Laura4 aut
700	1	a Payne, Felicity4 aut
700	1	a Pearson, Daniel4 aut
700	1	a Rathmann, Wolfgang4 aut
700	1	a Sandbaek, Annelli4 aut
700	1	a Sayer, Avan Aihie4 aut
700	1	a Scott, Laura J4 aut
700	1	a Sharp, Stephen J4 aut
700	1	a Sijbrands, Eric4 aut
700	1	a Singleton, Andrew4 aut
700	1	a Siscovick, David S4 aut
700	1	a Smith, Nicholas L4 aut
700	1	a Sparsø, Thomas4 aut
700	1	a Swift, Amy J4 aut
700	1	a Syddall, Holly4 aut
700	1	a Thorleifsson, Gudmar4 aut
700	1	a Tönjes, Anke4 aut
700	1	a Tuomi, Tiinamaija4 aut
700	1	a Tuomilehto, Jaakko4 aut
700	1	a Valle, Timo T4 aut
700	1	a Waeber, Gérard4 aut
700	1	a Walley, Andrew4 aut
700	1	a Waterworth, Dawn M4 aut
700	1	a Zeggini, Eleftheria4 aut
700	1	a Zhao, Jing Hua4 aut
700	1	a Illig, Thomas4 aut
700	1	a Wichmann, H Erich4 aut
700	1	a Wilson, James F4 aut
700	1	a van Duijn, Cornelia4 aut
700	1	a Hu, Frank B4 aut
700	1	a Morris, Andrew D4 aut
700	1	a Frayling, Timothy M4 aut
700	1	a Hattersley, Andrew T4 aut
700	1	a Thorsteinsdottir, Unnur4 aut
700	1	a Stefansson, Kari4 aut
700	1	a Nilsson, Peteru Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-pni
700	1	a Syvänen, Ann-Christineu Uppsala universitet,Molekylär medicin4 aut0 (Swepub:uu)anncsyva
700	1	a Shuldiner, Alan R4 aut
700	1	a Walker, Mark4 aut
700	1	a Bornstein, Stefan R4 aut
700	1	a Schwarz, Peter4 aut
700	1	a Williams, Gordon H4 aut
700	1	a Nathan, David M4 aut
700	1	a Kuusisto, Johanna4 aut
700	1	a Laakso, Markku4 aut
700	1	a Cooper, Cyrus4 aut
700	1	a Marmot, Michael4 aut
700	1	a Ferrucci, Luigi4 aut
700	1	a Mooser, Vincent4 aut
700	1	a Stumvoll, Michael4 aut
700	1	a Loos, Ruth J F4 aut
700	1	a Altshuler, David4 aut
700	1	a Psaty, Bruce M4 aut
700	1	a Rotter, Jerome I4 aut
700	1	a Boerwinkle, Eric4 aut
700	1	a Hansen, Torben4 aut
700	1	a Pedersen, Oluf4 aut
700	1	a Florez, Jose C4 aut
700	1	a McCarthy, Mark I4 aut
700	1	a Boehnke, Michael4 aut
700	1	a Barroso, Inês4 aut
700	1	a Sladek, Robert4 aut
700	1	a Froguel, Philippe4 aut
700	1	a Meigs, James B4 aut
700	1	a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr
700	1	a Wareham, Nicholas J4 aut
700	1	a Watanabe, Richard M4 aut
710	2	a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org
773	0	t Nature Geneticsd : Springer Science and Business Media LLCg 42:2, s. 142-148q 42:2<142-148x 1061-4036x 1546-1718
856	4	u https://cdr.lib.unc.edu/downloads/pr76fb134
856	4	u http://dx.doi.org/10.1038/ng.521y FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-131527
856	4 8	u https://doi.org/10.1038/ng.521
856	4 8	u https://lup.lub.lu.se/record/1569874
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:120004916

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Av författaren/redakt...: Saxena, Richa; Hivert, Marie-Fr ...; Langenberg, Clau ...; Tanaka, Toshiko; Pankow, James S; Vollenweider, Pe ...; visa fler...; Lyssenko, Valeri ...; Bouatia-Naji, Na ...; Dupuis, Josée; Jackson, Anne U; Kao, W H Linda; Li, Man; Glazer, Nicole L; Manning, Alisa K; Luan, Jian'an; Stringham, Heath ...; Prokopenko, Inga; Johnson, Toby; Grarup, Niels; Boesgaard, Trine ...; Lecoeur, Cécile; Shrader, Peter; O'Connell, Jeffr ...; Ingelsson, Erik; Couper, David J; Rice, Kenneth; Song, Kijoung; Andreasen, Camil ...; Dina, Christian; Köttgen, Anna; Le Bacquer, Oliv ...; Pattou, François; Taneera, Jalal; Steinthorsdottir ...; Rybin, Denis; Ardlie, Kristin; Sampson, Michael; Qi, Lu; van Hoek, Mandy; Weedon, Michael ...; Aulchenko, Yurii ...; Voight, Benjamin ...; Grallert, Harald; Balkau, Beverley; Bergman, Richard ...; Bielinski, Suzet ...; Bonnefond, Ameli ...; Bonnycastle, Lor ...; Borch-Johnsen, K ...; Böttcher, Yvonne; Brunner, Eric; Buchanan, Thomas ...; Bumpstead, Suzan ...; Cavalcanti-Proen ...; Charpentier, Gui ...; Chen, Yii-Der Id ...; Chines, Peter S; Collins, Francis ...; Cornelis, Marily ...; J Crawford, Gabr ...; Delplanque, Jero ...; Doney, Alex; Egan, Josephine ...; Erdos, Michael R; Firmann, Mathieu; Forouhi, Nita G; Fox, Caroline S; Goodarzi, Mark O; Graessler, Jürge ...; Hingorani, Aroon; Isomaa, Bo; Jørgensen, Torbe ...; Kivimaki, Mika; Kovacs, Peter; Krohn, Knut; Kumari, Meena; Lauritzen, Torst ...; Lévy-Marchal, Cl ...; Mayor, Vladimir; McAteer, Jarred ...; Meyre, David; Mitchell, Braxto ...; Mohlke, Karen L; Morken, Mario A; Narisu, Narisu; Palmer, Colin N ...; Pakyz, Ruth; Pascoe, Laura; Payne, Felicity; Pearson, Daniel; Rathmann, Wolfga ...; Sandbaek, Annell ...; Sayer, Avan Aihi ...; Scott, Laura J; Sharp, Stephen J; Sijbrands, Eric; Singleton, Andre ...; Siscovick, David ...; Smith, Nicholas ...; Sparsø, Thomas; Swift, Amy J; Syddall, Holly; Thorleifsson, Gu ...; Tönjes, Anke; Tuomi, Tiinamaij ...; Tuomilehto, Jaak ...; Valle, Timo T; Waeber, Gérard; Walley, Andrew; Waterworth, Dawn ...; Zeggini, Elefthe ...; Zhao, Jing Hua; Illig, Thomas; Wichmann, H Eric ...; Wilson, James F; van Duijn, Corne ...; Hu, Frank B; Morris, Andrew D; Frayling, Timoth ...; Hattersley, Andr ...; Thorsteinsdottir ...; Stefansson, Kari; Nilsson, Peter; Syvänen, Ann-Chr ...; Shuldiner, Alan ...; Walker, Mark; Bornstein, Stefa ...; Schwarz, Peter; Williams, Gordon ...; Nathan, David M; Kuusisto, Johann ...; Laakso, Markku; Cooper, Cyrus; Marmot, Michael; Ferrucci, Luigi; Mooser, Vincent; Stumvoll, Michae ...; Loos, Ruth J F; Altshuler, David; Psaty, Bruce M; Rotter, Jerome I; Boerwinkle, Eric; Hansen, Torben; Pedersen, Oluf; Florez, Jose C; McCarthy, Mark I; Boehnke, Michael; Barroso, Inês; Sladek, Robert; Froguel, Philipp ...; Meigs, James B; Groop, Leif; Wareham, Nichola ...; Watanabe, Richar ...; visa färre...

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