PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: (WFRF:(Young J Hunter)) pers:(Wareham Nicholas J) > PCSK9 genetic varia...

Details
MARC

Schmidt, Amand F.UCL, Inst Cardiovasc Sci, London NW1 2DA, England.;UCL, UCL Inst Hlth Informat, Farr Inst Hlth Informat Res, London, England. (author)

PCSK9 genetic variants and risk of type 2 diabetes : a mendelian randomisation study

Article/chapterEnglish2017

Publisher, publication year, extent ...

ELSEVIER SCIENCE INC,2017
electronicrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:uu-319119
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-319119URI
https://doi.org/10.1016/S2213-8587(16)30396-5DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Background Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest hyperglycaemia, increased bodyweight, and modestly increased risk of type 2 diabetes, which in no way off sets their substantial benefi ts. We sought to investigate the associations of LDL cholesterol-lowering PCSK9 variants with type 2 diabetes and related biomarkers to gauge the likely eff ects of PCSK9 inhibitors on diabetes risk. Methods In this mendelian randomisation study, we used data from cohort studies, randomised controlled trials, case control studies, and genetic consortia to estimate associations of PCSK9 genetic variants with LDL cholesterol, fasting blood glucose, HbA 1c, fasting insulin, bodyweight, waist-to-hip ratio, BMI, and risk of type 2 diabetes, using a standardised analysis plan, meta-analyses, and weighted gene-centric scores. Findings Data were available for more than 550 000 individuals and 51 623 cases of type 2 diabetes. Combined analyses of four independent PCSK9 variants (rs11583680, rs11591147, rs2479409, and rs11206510) scaled to 1 mmol/L lower LDL cholesterol showed associations with increased fasting glucose (0.09 mmol/L, 95% CI 0.02 to 0.15), bodyweight (1.03 kg, 0.24 to 1.82), waist-to-hip ratio (0.006, 0.003 to 0.010), and an odds ratio for type diabetes of 1.29 (1.11 to 1.50). Based on the collected data, we did not identify associations with HbA 1c (0.03%, -0.01 to 0.08), fasting insulin (0.00%, -0.06 to 0.07), and BMI (0.11 kg/m(2), -0.09 to 0.30). Interpretation PCSK9 variants associated with lower LDL cholesterol were also associated with circulating higher fasting glucose concentration, bodyweight, and waist-to-hip ratio, and an increased risk of type 2 diabetes. In trials of PCSK9 inhibitor drugs, investigators should carefully assess these safety outcomes and quantify the risks and benefi ts of PCSK9 inhibitor treatment, as was previously done for statins.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

Swerdlow, Daniel I.UCL, Inst Cardiovasc Sci, London NW1 2DA, England.;Imperial Coll London, Dept Med, Fac Med, London, England. (author)
Holmes, Michael V.Univ Oxford, Clin Trial Serv Unit, Nuffield Dept Populat Hlth, Oxford, England.;Univ Oxford, Epidemiol Studies Unit CTSU, Nuffield Dept Populat Hlth, Oxford, England.;Univ Oxford, Med Res Council, Populat Hlth Res Unit, Oxford, England. (author)
Patel, Riyaz S.UCL, Inst Cardiovasc Sci, London NW1 2DA, England.;UCL, UCL Inst Hlth Informat, Farr Inst Hlth Informat Res, London, England.;St Bartholomews Hosp, Barts Heart Ctr, London, England. (author)
Fairhurst-Hunter, ZammyUniv Oxford, Wellcome Trust Ctr Human Genet, Oxford, England. (author)
Lyall, Donald M.Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland. (author)
Hartwig, Fernando PiresUniv Fed Pelotas, Postgrad Program Epidemiol, Pelotas, Brazil. (author)
Horta, Bernardo LessaUniv Fed Pelotas, Postgrad Program Epidemiol, Pelotas, Brazil. (author)
Hypponen, ElinaUniv South Australia, Ctr Populat Hlth Res, Sansom Inst Hlth Res, Adelaide, SA, Australia.;UCL Great Ormond St Inst Child Hlth, Populat Policy & Practice, London, England.;South Australian Hlth & Med Res Inst, Adelaide, SA, Australia. (author)
Power, ChristineUCL Great Ormond St Inst Child Hlth, Populat Policy & Practice, London, England. (author)
Moldovan, MaxUniv South Australia, Sch Hlth Sci, Adelaide, SA, Australia.;EMBL Australia, South Australian Hlth & Med Res Inst, Adelaide, SA, Australia. (author)
van Iperen, ErikNetherlands Heart Inst, Durrer Ctr Cardiovasc Res, Utrecht, Netherlands.;Acad Med Ctr, Dept Clin Epidemiol Biostat & Bioinformat, Amsterdam, Netherlands. (author)
Hovingh, G. KeesAcad Med Ctr, Dept Vasc Med, Amsterdam, Netherlands. (author)
Demuth, IljaCharite Univ Med Berlin, Charite Res Grp Geriatr, Berlin, Germany.;Charite Univ Med Berlin, Inst Med & Human Genet, Berlin, Germany. (author)
Norman, KristinaCharite Univ Med Berlin, Charite Res Grp Geriatr, Berlin, Germany. (author)
Steinhagen-Thiessen, ElisabethCharite Univ Med Berlin, Charite Res Grp Geriatr, Berlin, Germany. (author)
Demuth, JuriE CA Econ GmbH, Berlin, Germany. (author)
Bertram, LarsImperial Coll London, Neuroepidemiol & Ageing Res Unit, Fac Med, London, England.;Univ Lubeck, Lubeck Interdisciplinary Platform Genome Analyt L, Inst Neurogenet, Lubeck, Germany.;Univ Lubeck, Lubeck Interdisciplinary Platform Genome Analyt L, Inst Integrat & Expt Genom, Lubeck, Germany. (author)
Liu, TianMax Planck Inst Human Dev, Berlin, Germany.;Max Planck Inst Mol Genet, Berlin, Germany. (author)
Coassin, StefanMed Univ Innsbruck, Dept Med Genet Mol & Clin Pharmacol, Div Genet Epidemiol Innsbruck, Innsbruck, Austria. (author)
Willeit, JohannMed Univ Innsbruck, Dept Neurol, Innsbruck, Austria. (author)
Kiechl, StefanMed Univ Innsbruck, Dept Neurol, Innsbruck, Austria. (author)
Willeit, KarinMed Univ Innsbruck, Dept Neurol, Innsbruck, Austria. (author)
Mason, DanBradford Royal Infirm, Bradford Inst Hlth Res, Bradford, W Yorkshire, England. (author)
Wright, JohnBradford Royal Infirm, Bradford Inst Hlth Res, Bradford, W Yorkshire, England. (author)
Morris, RichardUniv Bristol, Sch Social & Community Med, Bristol, Avon, England. (author)
Wanamethee, GoyaUCL, Dept Primary Care & Populat Hlth, London, England. (author)
Whincup, PeterSt Georges Univ London, Populat Hlth Res Inst, London, England. (author)
Ben-Shlomo, YoavUniv Bristol, Sch Social & Community Med, Bristol, Avon, England. (author)
McLachlan, StelaUniv Edinburgh, Ctr Populat Hlth Sci, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland. (author)
Price, Jackie F.Univ Edinburgh, Ctr Populat Hlth Sci, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland. (author)
Kivimaki, MikaUCL, UCL Inst Epidemiol & Hlth Care, Dept Epidemiol & Publ Hlth, London, England. (author)
Welch, CatherineUCL, UCL Inst Epidemiol & Hlth Care, Dept Epidemiol & Publ Hlth, London, England. (author)
Sanchez-Galvez, AdelaidaUCL, UCL Inst Epidemiol & Hlth Care, Dept Epidemiol & Publ Hlth, London, England. (author)
Marques-Vidal, PedroUniv Lausanne Hosp, Dept Med, Internal Med Unit, Lausanne, Switzerland. (author)
Nicolaides, AndrewImperial Coll London, Dept Vasc Surg, Fac Med, London, England.;Univ Nicosia, Nicosia Med Sch, Dept Surg, Nicosia, Cyprus. (author)
Panayiotou, Andrie G.Cyprus Univ Technol, Cyprus Int Inst Environm & Publ Hlth, Limassol, Cyprus. (author)
Onland-Moret, N. CharlotteUniv Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands. (author)
van der Schouw, Yvonne T.Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands. (author)
Matullo, GiuseppeHuman Genet Fdn, Turin, Italy.;Univ Turin, Dept Med Sci, Turin, Italy. (author)
Fiorito, GiovanniHuman Genet Fdn, Turin, Italy.;Univ Turin, Dept Med Sci, Turin, Italy. (author)
Guarrera, SimonettaHuman Genet Fdn, Turin, Italy.;Univ Turin, Dept Med Sci, Turin, Italy. (author)
Sacerdote, CarlottaSan Giovanni Battista Hosp, Canc Epidemiol Unit, Turin, Italy.;CPO Piemonte, Ctr Oncol Prevent, Turin, Italy. (author)
Wareham, Nicholas J.Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Inst Metab Sci, Cambridge, England. (author)
Langenberg, ClaudiaUniv Cambridge, Sch Clin Med, MRC Epidemiol Unit, Inst Metab Sci, Cambridge, England. (author)
Scott, RobertUniv Cambridge, Sch Clin Med, MRC Epidemiol Unit, Inst Metab Sci, Cambridge, England. (author)
Luan, Jian'anUniv Cambridge, Sch Clin Med, MRC Epidemiol Unit, Inst Metab Sci, Cambridge, England. (author)
Bobak, MartinUCL, UCL Inst Epidemiol & Hlth Care, Dept Epidemiol & Publ Hlth, London, England. (author)
Malyutina, Sofi A.Novosibirsk State Med Univ, Novosibirsk, Russia.;Russian Acad Med Sci, Inst Internal & Prevent Med, Siberian Branch, Novosibirsk, Russia. (author)
Pajak, AndrzejJagiellonian Univ, Coll Med, Krakow, Poland. (author)
Kubinova, RuzenaNatl Inst Publ Hlth, Prague, Czech Republic. (author)
Tamosiunas, AbdonasLithuanian Univ Hlth Sci, Kaunas, Lithuania. (author)
Pikhart, HynekUCL, UCL Inst Epidemiol & Hlth Care, Dept Epidemiol & Publ Hlth, London, England. (author)
Husemoen, Lise Lotte NystrupCapital Reg Denmark, Res Ctr Prevent & Hlth, Copenhagen, Denmark. (author)
Grarup, NielsUniv Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Basic Metab Res, Copenhagen, Denmark. (author)
Pedersen, OlufUniv Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Basic Metab Res, Copenhagen, Denmark. (author)
Hansen, TorbenUniv Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Basic Metab Res, Copenhagen, Denmark. (author)
Linneberg, AllanCapital Reg Denmark, Res Ctr Prevent & Hlth, Copenhagen, Denmark.;Rigshosp, Dept Clin Expt Res, Copenhagen, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark. (author)
Simonsen, Kenneth StarupCapital Reg Denmark, Res Ctr Prevent & Hlth, Copenhagen, Denmark. (author)
Cooper, JackieUCL, Ctr Cardiovasc Genet, London, England. (author)
Humphries, Steve E.UCL, Ctr Cardiovasc Genet, London, England. (author)
Brilliant, MurrayMarshfield Clin Res Fdn, Ctr Human Genet, Marshfield, WI USA. (author)
Kitchner, TerrieMarshfield Clin Res Fdn, Ctr Human Genet, Marshfield, WI USA. (author)
Hakonarson, HakonChildrens Hosp Philadelphia, Philadelphia, PA 19104 USA. (author)
Carrell, David S.Grp Hlth Res Inst, Seattle, WA USA. (author)
McCarty, Catherine A.Essentia Inst Rural Hlth, Duluth, MN USA. (author)
Kirchner, H. LesterGeisinger Med Clin, Ctr Hlth Res, Danville, PA USA. (author)
Larson, Eric B.Grp Hlth Res Inst, Seattle, WA USA. (author)
Crosslin, David R.Grp Hlth Res Inst, Seattle, WA USA. (author)
de Andrade, MarizaMayo Clin, Div Biomed Stat & Informat, Rochester, MN USA. (author)
Roden, Dan M.Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37212 USA.;Vanderbilt Univ, Sch Med, Dept Pharmacol, Nashville, TN 37212 USA. (author)
Denny, Joshua C.Vanderbilt Univ, Sch Med, Dept Biomed Informat, Nashville, TN 37212 USA. (author)
Carty, CaraGeorge Washington Univ, Washington, DC USA. (author)
Hancock, StephenUniv Newcastle, Newcastle, NSW, Australia. (author)
Attia, JohnUniv Newcastle, Newcastle, NSW, Australia. (author)
Holliday, ElizabethUniv Newcastle, Newcastle, NSW, Australia. (author)
Donnell, Martin O'Populat Hlth Res Inst, Hamilton, ON, Canada. (author)
Yusuf, SalimPopulat Hlth Res Inst, Hamilton, ON, Canada. (author)
Chong, MichaelPopulat Hlth Res Inst, Hamilton, ON, Canada. (author)
Pare, GuillaumePopulat Hlth Res Inst, Hamilton, ON, Canada. (author)
van der Harst, PimNetherlands Heart Inst, Durrer Ctr Cardiovasc Res, Utrecht, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands. (author)
Said, M. AbdullahUniv Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands. (author)
Eppinga, Ruben N.Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands. (author)
Verweij, NiekUniv Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands. (author)
Snieder, HaroldUniv Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands. (author)
Christen, TimLeiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands. (author)
Mook-Kanamori, Dennis O.Leiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands. (author)
Gustafsson, StefanUppsala universitet,Molekylär epidemiologi(Swepub:uu)stegu732 (author)
Lind, LarsUppsala universitet,Molekylär epidemiologi(Swepub:uu)larslind (author)
Ingelsson, ErikUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Stanford Univ, Dept Med, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA.(Swepub:uu)ering425 (author)
Pazoki, RahaErasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands. (author)
Franco, OscarErasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands. (author)
Hofman, AlbertErasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands. (author)
Uitterlinden, AndreErasmus Univ, Med Ctr, Dept Internal Med, Rotterdam, Netherlands. (author)
Dehghan, AbbasImperial Coll London, Sch Publ Hlth, MRC PHE Ctr Environm & Hlth, Dept Biostat & Epidemiol, London, England.;Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands. (author)
Teumer, AlexanderUniv Med Greifswald, Inst Community Med, Greifswald, Germany.;German Ctr Cardiovasc Res DZHK, Greifswald, Germany. (author)
Baumeister, SebastianUniv Med Greifswald, Inst Community Med, Greifswald, Germany.;Univ Regensburg, Dept Epidemiol & Prevent Med, Regensburg, Germany. (author)
Doerr, MarcusUniv Med Greifswald, Dept Internal Med B, Greifswald, Germany.;German Ctr Cardiovasc Res DZHK, Greifswald, Germany. (author)
Lerch, Markus M.Univ Med Greifswald, Dept Med A, Greifswald, Germany. (author)
Voelker, UweUniv Med Greifswald, Interfac Inst Genet & Funct Genom, Greifswald, Germany.;German Ctr Cardiovasc Res DZHK, Greifswald, Germany. (author)
Voelzke, HenryUniv Med Greifswald, Inst Community Med, Greifswald, Germany.;German Ctr Cardiovasc Res DZHK, Greifswald, Germany. (author)
Ward, JoeyUniv Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland. (author)
Pell, Jill P.Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland. (author)
Smith, Daniel J.Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland. (author)
Meade, TomLondon Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London, England. (author)
Maitland-van der Zee, Anke H.Acad Med Ctr, Dept Resp Med, Amsterdam, Netherlands.;Univ Utrecht, Fac Sci, Utrecht Inst Pharmaceut Sci, Div Pharmacoepidemiol & Clin Pharmacol, Utrecht, Netherlands. (author)
Baranova, Ekaterina V.Univ Utrecht, Fac Sci, Utrecht Inst Pharmaceut Sci, Div Pharmacoepidemiol & Clin Pharmacol, Utrecht, Netherlands. (author)
Young, RobinUniv Glasgow, Robertson Ctr Biostat, Glasgow, Lanark, Scotland. (author)
Ford, IanUniv Glasgow, Robertson Ctr Biostat, Glasgow, Lanark, Scotland. (author)
Campbell, ArchieUniv Edinburgh, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland. (author)
Padmanabhan, SandoshUniv Glasgow, Cardiovasc & Med Sci, Glasgow, Lanark, Scotland. (author)
Bots, Michiel L.Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands. (author)
Grobbee, Diederick E.Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands. (author)
Froguel, PhilippeImperial Coll London, Fac Med, Dept Genom Common Dis, London, England.;Univ Lille, Inst Pasteur Lille, EGID, CNRS,UMR 8199, Lille, France. (author)
Thuillier, DorotheeUniv Lille, Inst Pasteur Lille, EGID, CNRS,UMR 8199, Lille, France. (author)
Balkau, BeverleyINSERM, U1018, Ctr Rech Epidemiol & Sante Populat CESP, Renal & Cardiovasc Epidemiol, Villejuif, France. (author)
Bonnefond, AmelieImperial Coll London, Fac Med, Dept Genom Common Dis, London, England.;Univ Lille, Inst Pasteur Lille, EGID, CNRS,UMR 8199, Lille, France. (author)
Cariou, BertrandUniv Nantes, CHU Nantes, Inst Thorax, INSERM,CNRS, Nantes, France. (author)
Smart, MelissaUniv Essex, Inst Social & Econ Res, Colchester, Essex, England. (author)
Bao, YanchunUniv Essex, Inst Social & Econ Res, Colchester, Essex, England. (author)
Kumari, MeenaUniv Essex, Inst Social & Econ Res, Colchester, Essex, England. (author)
Mahajan, AnubhaUniv Oxford, Wellcome Trust Ctr Human Genet, Oxford, England. (author)
Ridker, Paul M.Harvard Med Sch, Brigham & Womens Hosp, Ctr Cardiovasc Dis Prevent, Boston, MA USA. (author)
Chasman, Daniel I.Harvard Med Sch, Brigham & Womens Hosp, Ctr Cardiovasc Dis Prevent, Boston, MA USA. (author)
Reiner, Alex P.Univ Washington, Fred Hutchinson Canc Res Ctr, Dept Epidemiol, Seattle, WA 98195 USA. (author)
Lange, Leslie A.Univ Colorado, Anschutz Med Campus, Denver, CO 80202 USA. (author)
Ritchie, Marylyn D.Geisinger Hlth Syst, Biomed & Translat Informat, Danville, PA USA.;Penn State Univ, Huck Inst Life Sci, Dept Biochem & Mol Biol, University Pk, PA 16802 USA. (author)
Asselbergs, Folkert W.UCL, Inst Cardiovasc Sci, London NW1 2DA, England.;UCL, UCL Inst Hlth Informat, Farr Inst Hlth Informat Res, London, England.;Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.;Univ Med Ctr Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands. (author)
Casas, Juan-PabloUCL, UCL Inst Hlth Informat, Farr Inst Hlth Informat Res, London, England. (author)
Keating, Brendan J.Univ Penn, Dept Surg, Philadelphia, PA 19104 USA. (author)
Preiss, DavidUniv Oxford, Clin Trial Serv Unit, Nuffield Dept Populat Hlth, Oxford, England.;Univ Oxford, Epidemiol Studies Unit CTSU, Nuffield Dept Populat Hlth, Oxford, England.;Univ Oxford, Med Res Council, Populat Hlth Res Unit, Oxford, England. (author)
Hingorani, Aroon D.UCL, Inst Cardiovasc Sci, London NW1 2DA, England.;UCL, UCL Inst Hlth Informat, Farr Inst Hlth Informat Res, London, England. (author)
Sattar, NaveedUniv Glasgow, Cardiovasc & Med Sci, Glasgow, Lanark, Scotland. (author)
UCL, Inst Cardiovasc Sci, London NW1 2DA, England.;UCL, UCL Inst Hlth Informat, Farr Inst Hlth Informat Res, London, England.UCL, Inst Cardiovasc Sci, London NW1 2DA, England.;Imperial Coll London, Dept Med, Fac Med, London, England. (creator_code:org_t)

Related titles

In:The Lancet Diabetes and Endocrinology: ELSEVIER SCIENCE INC5:2, s. 97-1052213-85872213-8595

Internet link

Find in a library

The Lancet Diabetes and Endocrinology (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Schmidt, Amand F ...; Swerdlow, Daniel ...; Holmes, Michael ...; Patel, Riyaz S.; Fairhurst-Hunter ...; Lyall, Donald M.; show more...; Hartwig, Fernand ...; Horta, Bernardo ...; Hypponen, Elina; Power, Christine; Moldovan, Max; van Iperen, Erik; Hovingh, G. Kees; Demuth, Ilja; Norman, Kristina; Steinhagen-Thies ...; Demuth, Juri; Bertram, Lars; Liu, Tian; Coassin, Stefan; Willeit, Johann; Kiechl, Stefan; Willeit, Karin; Mason, Dan; Wright, John; Morris, Richard; Wanamethee, Goya; Whincup, Peter; Ben-Shlomo, Yoav; McLachlan, Stela; Price, Jackie F.; Kivimaki, Mika; Welch, Catherine; Sanchez-Galvez, ...; Marques-Vidal, P ...; Nicolaides, Andr ...; Panayiotou, Andr ...; Onland-Moret, N. ...; van der Schouw, ...; Matullo, Giusepp ...; Fiorito, Giovann ...; Guarrera, Simone ...; Sacerdote, Carlo ...; Wareham, Nichola ...; Langenberg, Clau ...; Scott, Robert; Luan, Jian'an; Bobak, Martin; Malyutina, Sofi ...; Pajak, Andrzej; Kubinova, Ruzena; Tamosiunas, Abdo ...; Pikhart, Hynek; Husemoen, Lise L ...; Grarup, Niels; Pedersen, Oluf; Hansen, Torben; Linneberg, Allan; Simonsen, Kennet ...; Cooper, Jackie; Humphries, Steve ...; Brilliant, Murra ...; Kitchner, Terrie; Hakonarson, Hako ...; Carrell, David S ...; McCarty, Catheri ...; Kirchner, H. Les ...; Larson, Eric B.; Crosslin, David ...; de Andrade, Mari ...; Roden, Dan M.; Denny, Joshua C.; Carty, Cara; Hancock, Stephen; Attia, John; Holliday, Elizab ...; Donnell, Martin ...; Yusuf, Salim; Chong, Michael; Pare, Guillaume; van der Harst, P ...; Said, M. Abdulla ...; Eppinga, Ruben N ...; Verweij, Niek; Snieder, Harold; Christen, Tim; Mook-Kanamori, D ...; Gustafsson, Stef ...; Lind, Lars; Ingelsson, Erik; Pazoki, Raha; Franco, Oscar; Hofman, Albert; Uitterlinden, An ...; Dehghan, Abbas; Teumer, Alexande ...; Baumeister, Seba ...; Doerr, Marcus; Lerch, Markus M.; Voelker, Uwe; Voelzke, Henry; Ward, Joey; Pell, Jill P.; Smith, Daniel J.; Meade, Tom; Maitland-van der ...; Baranova, Ekater ...; Young, Robin; Ford, Ian; Campbell, Archie; Padmanabhan, San ...; Bots, Michiel L.; Grobbee, Diederi ...; Froguel, Philipp ...; Thuillier, Dorot ...; Balkau, Beverley; Bonnefond, Ameli ...; Cariou, Bertrand; Smart, Melissa; Bao, Yanchun; Kumari, Meena; Mahajan, Anubha; Ridker, Paul M.; Chasman, Daniel ...; Reiner, Alex P.; Lange, Leslie A.; Ritchie, Marylyn ...; Asselbergs, Folk ...; Casas, Juan-Pabl ...; Keating, Brendan ...; Preiss, David; Hingorani, Aroon ...; Sattar, Naveed; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

Articles in the publication: The Lancet Diabe ...

By the university: Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se