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Dietary Flavonoid I...
Dietary Flavonoid Intake and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Cohort
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Vermeulen, Esther (author)
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Zamora-Ros, Raul (author)
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Duell, Eric J. (author)
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Lujan-Barroso, Leila (author)
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Boeing, Heiner (author)
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Aleksandrova, Krasimira (author)
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Bueno-de-Mesquita, H. Bas (author)
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Scalbert, Augustin (author)
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Romieu, Isabelle (author)
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Fedirko, Veronika (author)
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Touillaud, Marina (author)
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Fagherazzi, Guy (author)
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Perquier, Florence (author)
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Molina-Montes, Esther (author)
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Chirlaque, Maria-Dolores (author)
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Argueelles, Marcial Vicente (author)
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Amiano, Pilar (author)
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Barricarte, Aurelio (author)
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Pala, Valeria (author)
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Mattiello, Amalia (author)
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Saieva, Calogero (author)
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Tumino, Rosario (author)
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Ricceri, Fulvio (author)
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Trichopoulou, Antonia (author)
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Vasilopoulou, Effie (author)
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Ziara, Gianna (author)
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Crowe, Francesca L. (author)
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Khaw, Kay-Thee (author)
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Wareham, Nicholas J. (author)
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Vasilopoulou, Effie (author)
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Ziara, Gianna (author)
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Crowe, Francesca L. (author)
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Khaw, Kay-Thee (author)
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Wareham, Nicholas J. (author)
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Lukanova, Annekatrin (author)
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Grote, Verena A. (author)
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Tjonneland, Anne (author)
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Halkjaer, Jytte (author)
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Bredsdorff, Lea (author)
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Overvad, Kim (author)
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Siersema, Peter D. (author)
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Peeters, Petra H. M. (author)
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May, Anne M. (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Skeie, Guri (author)
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Hjartaker, Anette (author)
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- Landberg, Rikard (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för livsmedelsvetenskap,Department of Food Science
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- Johansson, Ingegerd (author)
- Umeå universitet,Tandläkarutbildning
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- Sonestedt, Emily (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Ericson, Ulrika (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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Riboli, Elio (author)
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Gonzalez, Carlos A. (author)
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(creator_code:org_t)
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- 2013-05-06
- 2013
- English.
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In: American Journal of Epidemiology. - : Oxford University Press (OUP). - 0002-9262 .- 1476-6256. ; 178:4, s. 570-581
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https://urn.kb.se/re...
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Abstract
Subject headings
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- We prospectively investigated dietary flavonoid intake and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The study included 477,312 adult subjects from 10 European countries. At baseline, country-specific validated dietary questionnaires were used. During a mean follow-up of 11 years (1992-2010), there were 341 incident esophageal cancer cases, of which 142 were esophageal adenocarcinoma (EAC), 176 were esophageal squamous cell carcinoma (ESCC), and 23 were other types of esophageal cancer. In crude models, a doubling in total dietary flavonoid intake was inversely associated with esophageal cancer risk (hazard ratio (HR) (log(2))=0.87, 95% confidence interval (CI): 0.78, 0.98) but not in multi-variable models (HR (log(2))=0.97, 95% CI: 0.86, 1.10). After covariate adjustment, no statistically significant association was found between any flavonoid subclass and esophageal cancer, EAC, or ESCC. However, among current smokers, flavonols were statistically significantly associated with a reduced esophageal cancer risk (HR (log(2)) = 0.72, 95% CI: 0.56, 0.94), whereas total flavonoids, flavanols, and flavan-3-ol monomers tended to be inversely associated with esophageal cancer risk. No associations were found in either never or former smokers. These findings suggest that dietary flavonoid intake was not associated with overall esophageal cancer, EAC, or ESCC risk, although total flavonoids and some flavonoid subclasses, particularly flavonols, may reduce the esophageal cancer risk among current smokers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- esophageal cancer
- European Prospective Investigation into Cancer and
- Nutrition
- flavonoids
- intake
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Vermeulen, Esthe ...
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Zamora-Ros, Raul
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Duell, Eric J.
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Lujan-Barroso, L ...
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Boeing, Heiner
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Aleksandrova, Kr ...
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show more...
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Bueno-de-Mesquit ...
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Scalbert, August ...
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Romieu, Isabelle
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Fedirko, Veronik ...
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Touillaud, Marin ...
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Fagherazzi, Guy
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Perquier, Floren ...
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Molina-Montes, E ...
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Chirlaque, Maria ...
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Argueelles, Marc ...
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Amiano, Pilar
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Barricarte, Aure ...
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Pala, Valeria
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Mattiello, Amali ...
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Saieva, Calogero
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Tumino, Rosario
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Ricceri, Fulvio
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Trichopoulou, An ...
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Vasilopoulou, Ef ...
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Ziara, Gianna
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Crowe, Francesca ...
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Khaw, Kay-Thee
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Wareham, Nichola ...
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Lukanova, Anneka ...
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Grote, Verena A.
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Tjonneland, Anne
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Halkjaer, Jytte
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Bredsdorff, Lea
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Overvad, Kim
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Siersema, Peter ...
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Peeters, Petra H ...
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May, Anne M.
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Weiderpass, Elis ...
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Skeie, Guri
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Hjartaker, Anett ...
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Landberg, Rikard
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Johansson, Ingeg ...
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Sonestedt, Emily
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Ericson, Ulrika
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Riboli, Elio
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Gonzalez, Carlos ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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American Journal ...
- By the university
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Lund University
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Swedish University of Agricultural Sciences
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Karolinska Institutet
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Umeå University