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Alcohol intake and ...
Alcohol intake and breast cancer in the European Prospective investigation into Cancer and Nutrition : Short title
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Romieu, Isabelle (author)
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Scoccianti, Chiara (author)
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Chajes, Veronique (author)
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de Batlle, Jordi (author)
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Biessy, Carine (author)
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Dossus, Laure (author)
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Baglietto, Laura (author)
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Clavel-Chapelon, Françoise (author)
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Overvad, Kim (author)
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Olsen, Anja (author)
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Tjønneland, Anne (author)
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Kaaks, Rudolf (author)
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- Lukanova, Annekatrin (author)
- Umeå universitet,Patologi
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Boeing, Heiner (author)
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Trichopoulou, Antonia (author)
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Lagiou, Pagona (author)
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Trichopoulos, Dimitrios (author)
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Palli, Domenico (author)
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Sieri, Sabina (author)
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Tumino, Rosario (author)
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Vineis, Paolo (author)
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Panico, Salvatore (author)
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Bueno-de-Mesquita, H B As (author)
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Gils, Carla H (author)
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Peeters, Petra (author)
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Lund, Eiliv (author)
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Skeie, Guri (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Quirós, J Ramón (author)
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Chirlaque, María-Dolores (author)
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Ardanaz, Eva (author)
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Sánchez, María-José (author)
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Duell, Eric J (author)
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Amiano, Pilar (author)
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- Borgquist, Signe (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Wirfält, Elisabet (author)
- Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups
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- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning,Enheten för biobanksforskning
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- Johansson, Ingegerd (author)
- Umeå universitet,Institutionen för odontologi,Näringsforskning
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- Nilsson, Lena Maria (author)
- Umeå universitet,Näringsforskning
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Khaw, Kay-Tee (author)
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Wareham, Nick (author)
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Key, Timothy J (author)
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Travis, Ruth C (author)
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Murphy, Neil (author)
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Wark, Petra A (author)
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Ferrari, Pietro (author)
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Riboli, Elio (author)
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(creator_code:org_t)
- 2015-07-14
- 2015
- English.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 137:8, s. 1921-1930
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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Abstract
Subject headings
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- Alcohol intake has been associated to breast cancer in pre and postmenopausal women; however results are inconclusive regarding tumor hormonal receptor status, and potential modifying factors like age at start drinking. Therefore, we investigated the relation between alcohol intake and the risk of breast cancer using prospective observational data from the European Prospective Investigation into Cancer and Nutrition (EPIC). Up to 334,850 women, aged 35-70 years at baseline, were recruited in ten European countries and followed up an average of 11 years. Alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. The study outcomes were the Hazard ratios (HR) of developing breast cancer according to hormonal receptor status. During 3,670,439 person-years, 11,576 incident breast cancer cases were diagnosed. Alcohol intake was significantly related to breast cancer risk, for each 10 g/day increase in alcohol intake the HR increased by 4.2% (95% CI: 2.7-5.8%). Taking 0 to 5 g/day as reference, alcohol intake of >5 to 15 g/day was related to a 5.9% increase in breast cancer risk (95% CI: 1-11%). Significant increasing trends were observed between alcohol intake and ER+/PR+, ER-/PR-, HER2- and ER-/PR-HER2- tumors. Breast cancer risk was stronger among women who started drinking prior to first full-time pregnancy. Overall, our results confirm the association between alcohol intake and both hormone receptor positive and hormone receptor negative breast tumors, suggesting that timing of exposure to alcohol drinking may affect the risk. Therefore, women should be advised to control their alcohol consumption. What's new? Although it is now established that alcohol consumption increases breast cancer risk, many questions remain. Using a prospective study design with 11,576 incident breast cancer cases across 10 European countries, the authors confirmed the increased risk of alcohol on breast cancer development. They further show that women who started drinking before their first full-term pregnancy have a higher risk than women who started afterwards. These effects were observed in hormone-receptor positive and -negative tumors pointing to non-hormonal pathways that need to be further investigated.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Alcohol consumption
- Breast cancer
- Prospective study
- prospective study
- breast cancer
- alcohol consumption
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Romieu, Isabelle
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Scoccianti, Chia ...
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Chajes, Veroniqu ...
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de Batlle, Jordi
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Biessy, Carine
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Dossus, Laure
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show more...
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Baglietto, Laura
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Clavel-Chapelon, ...
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Overvad, Kim
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Olsen, Anja
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Tjønneland, Anne
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Kaaks, Rudolf
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Lukanova, Anneka ...
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Boeing, Heiner
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Trichopoulou, An ...
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Lagiou, Pagona
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Trichopoulos, Di ...
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Palli, Domenico
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Sieri, Sabina
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Tumino, Rosario
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Vineis, Paolo
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Panico, Salvator ...
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Bueno-de-Mesquit ...
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Gils, Carla H
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Peeters, Petra
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Lund, Eiliv
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Skeie, Guri
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Weiderpass, Elis ...
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Quirós, J Ramón
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Chirlaque, María ...
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Ardanaz, Eva
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Sánchez, María-J ...
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Duell, Eric J
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Amiano, Pilar
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Borgquist, Signe
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Wirfält, Elisabe ...
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Hallmans, Göran
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Johansson, Ingeg ...
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Nilsson, Lena Ma ...
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Khaw, Kay-Tee
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Wareham, Nick
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Key, Timothy J
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Travis, Ruth C
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Murphy, Neil
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Wark, Petra A
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Ferrari, Pietro
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Riboli, Elio
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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International Jo ...
- By the university
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Umeå University
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Lund University
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Karolinska Institutet