Sökning: (swepub) lar1:(umu) pers:(Riboli Elio) pers:(Krogh Vittorio) pers:(Navarro Carmen) pers:(Khaw Kay Tee) > (2010-2014) > Genetic variation i...
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000 | 05543naa a2200841 4500 | |
001 | oai:lup.lub.lu.se:093a827e-00a0-4c14-a6d8-79f72bf4af79 | |
003 | SwePub | |
008 | 160401s2012 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-52851 | |
024 | 7 | a https://lup.lub.lu.se/record/24098952 URI |
024 | 7 | a https://doi.org/10.1093/carcin/bgr2852 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-528512 URI |
040 | a (SwePub)lud (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Duell, Eric J.4 aut |
245 | 1 0 | a Genetic variation in alcohol dehydrogenase (ADH1A, ADH1B, ADH1C, ADH7) and aldehyde dehydrogenase (ALDH2), alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort |
264 | c 2011-12-05 | |
264 | 1 | a Oxford :b Oxford University Press (OUP),c 2012 |
520 | a Studies that have examined the association between alcohol consumption and gastric cancer (GC) risk have been inconsistent. We conducted an investigation of 29 genetic variants in alcohol metabolism loci (alcohol dehydrogenase, ADH1 gene cluster: ADH1A, ADH1B and ADH1C; ADH7 and aldehyde dehydrogenase, ALDH2), alcohol intake and GC risk. We analyzed data from a nested case-control study (364 cases and 1272 controls) within the European Prospective Investigation into Cancer and Nutrition cohort. Single nucleotide polymorphisms (SNPs) were genotyped using a customized array. We observed a statistically significant association between a common 3'-flanking SNP near ADH1A (rs1230025) and GC risk [allelic odds ratio (OR)(A v T) = 1.30, 95% confidence interval (CI) = 1.07-1.59]. Two intronic variants, one in ADH1C (rs283411) and one in ALDH2 (rs16941667), also were associated with GC risk (ORT v C = 0.59; 95% CI = 0.38-0.91 and ORT v C = 1.34; 95% CI = 1.00-1.79, respectively). Individuals carrying variant alleles at both ADH1 (rs1230025) and ALDH2 (rs16941667) were twice as likely to develop GC (ORA+T = 2.0; 95% CI = 1.25-3.20) as those not carrying variant alleles. The association between rs1230025 and GC was modified by alcohol intake (< 5 g/day: ORA = 0.89, 95% CI = 0.57-1.39; >= 5 g/day: ORA = 1.45, 95% CI = 1.08-1.94, P-value = 0.05). The association was also modified by ethanol intake from beer. A known functional SNP in ADH1B (rs1229984) was associated with alcohol intake (P-value = 0.04) but not GC risk. Variants in ADH7 were not associated with alcohol intake or GC risk. In conclusion, genetic variants at ADH1 and ALDH2 loci may influence GC risk, and alcohol intake may further modify the effect of ADH1 rs1230025. Additional population-based studies are needed to confirm our results. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Sala, Nuria4 aut |
700 | 1 | a Travier, Noemie4 aut |
700 | 1 | a Munoz, Xavier4 aut |
700 | 1 | a Christine Boutron-Ruault, Marie4 aut |
700 | 1 | a Clavel-Chapelon, Francoise4 aut |
700 | 1 | a Barricarte, Aurelio4 aut |
700 | 1 | a Arriola, Larraitz4 aut |
700 | 1 | a Navarro, Carmen4 aut |
700 | 1 | a Sanchez-Cantalejo, Emilio4 aut |
700 | 1 | a Ramon Quiros, J.4 aut |
700 | 1 | a Krogh, Vittorio4 aut |
700 | 1 | a Vineis, Paolo4 aut |
700 | 1 | a Mattiello, Amalia4 aut |
700 | 1 | a Tumino, Rosario4 aut |
700 | 1 | a Khaw, Kay-Tee4 aut |
700 | 1 | a Wareham, Nicholas4 aut |
700 | 1 | a Allen, Naomi E.4 aut |
700 | 1 | a Peeters, Petra H.4 aut |
700 | 1 | a Numans, Mattijs E.4 aut |
700 | 1 | a Bueno-de-Mesquita, H. B.4 aut |
700 | 1 | a Hallmans, Göranu Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001 |
700 | 1 | a Bamia, Christina4 aut |
700 | 1 | a Benetou, Vassiliki4 aut |
700 | 1 | a Trichopoulos, Dimitrios4 aut |
700 | 1 | a Canzian, Federico4 aut |
700 | 1 | a Kaaks, Rudolf4 aut |
700 | 1 | a Boeing, Heiner4 aut |
700 | 1 | a Bergmann, Manuela M.4 aut |
700 | 1 | a Lund, Eiliv4 aut |
700 | 1 | a Ehrnström, Royu Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)pat-reh |
700 | 1 | a Johansen, Dortheu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)kirm-djo |
700 | 1 | a Hallmans, Goran4 aut |
700 | 1 | a Stenling, Rogeru Umeå universitet,Patologi4 aut0 (Swepub:umu)rost0001 |
700 | 1 | a Tjonneland, Anne4 aut |
700 | 1 | a Overvad, Kim4 aut |
700 | 1 | a Ostergaard, Jane Nautrup4 aut |
700 | 1 | a Ferrari, Pietro4 aut |
700 | 1 | a Fedirko, Veronika4 aut |
700 | 1 | a Jenab, Mazda4 aut |
700 | 1 | a Nesi, Gabriella4 aut |
700 | 1 | a Riboli, Elio4 aut |
700 | 1 | a Gonzalez, Carlos A.4 aut |
710 | 2 | a Umeå universitetb Näringsforskning4 org |
773 | 0 | t Carcinogenesisd Oxford : Oxford University Press (OUP)g 33:2, s. 361-367q 33:2<361-367x 0143-3334x 1460-2180 |
856 | 4 | u http://dx.doi.org/10.1093/carcin/bgr285y FULLTEXT |
856 | 4 | u https://academic.oup.com/carcin/article-pdf/33/2/361/7459302/bgr285.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/2409895 |
856 | 4 8 | u https://doi.org/10.1093/carcin/bgr285 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-52851 |
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