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Circulating 25-Hydr...
Circulating 25-Hydroxyvitamin D-3 in Relation to Renal Cell Carcinoma Incidence and Survival in the EPIC Cohort
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Muller, David C. (author)
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Fanidi, Anouar (author)
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Midttun, Oivind (author)
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Steffen, Annika (author)
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Dossus, Laure (author)
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Boutron-Ruault, Marie-Christine (author)
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Severi, Gianluca (author)
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Kuehn, Tilman (author)
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Katzke, Verena (author)
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Alonso de la Torreon, Ramon (author)
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Gonzalez, Carlos A. (author)
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Sanchez, Maria-Jose (author)
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Dorronsoro, Miren (author)
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Santiuste, Carmen (author)
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Barricarte, Aurelio (author)
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Khaw, Kay-Tee (author)
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Wareham, Nick (author)
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Travis, Ruth C. (author)
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Trichopoulou, Antonia (author)
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Giotaki, Maria (author)
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Trichopoulos, Dimitrios (author)
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Palli, Domenico (author)
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Krogh, Vittorio (author)
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Tumino, Rosario (author)
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Vineis, Paolo (author)
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Panico, Salvatore (author)
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Tjonneland, Anne (author)
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Olsen, Anja (author)
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Bueno-de-Mesquita, H. Bas (author)
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Peeters, Petra H. (author)
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- Ljungberg, Börje (author)
- Umeå universitet,Urologi och andrologi,Njurcancer
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- Wennberg, Maria (author)
- Umeå universitet,Näringsforskning
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Murphy, Neil (author)
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Riboli, Elio (author)
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Ueland, Per Magne (author)
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Boeing, Heiner (author)
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Brennan, Paul (author)
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- Johansson, Mattias (author)
- International Agency for Research on Cancer (IARC-WHO), Lyon, France
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(creator_code:org_t)
- 2014-09-08
- 2014
- English.
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In: American Journal of Epidemiology. - : Oxford University Press (OUP). - 0002-9262 .- 1476-6256. ; 180:8, s. 810-820
- Related links:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Normal renal function is essential for vitamin D metabolism, but it is unclear whether circulating vitamin D is associated with risk of renal cell carcinoma (RCC). We assessed whether 25-hydroxyvitamin D-3 (25(OH)D-3) was associated with risk of RCC and death after RCC diagnosis in the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC recruited 385,747 participants with blood samples between 1992 and 2000. The current study included 560 RCC cases, 557 individually matched controls, and 553 additional controls. Circulating 25(OH)D-3 was assessed by mass spectrometry. Conditional and unconditional logistic regression models were used to calculate odds ratios and 95% confidence intervals. Death after RCC diagnosis was assessed using Cox proportional hazards models and flexible parametric survival models. A doubling of 25(OH)D-3 was associated with 28% lower odds of RCC after adjustment for season of and age at blood collection, sex, and country of recruitment (odds ratio = 0.72, 95% confidence interval: 0.60, 0.86; P = 0.0004). This estimatewas attenuated somewhat after additional adjustment for smoking status at baseline, circulating cotinine, body mass index (weight (kg)/height (m)(2)), and alcohol intake (odds ratio = 0.82, 95% confidence interval: 0.68, 0.99; P = 0.038). There was also some indication that both low and high 25(OH)D-3 levels were associated with higher risk of death from any cause among RCC cases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- nested case-control study
- prospective study
- renal cell carcinoma
- vitamin D
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Muller, David C.
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Fanidi, Anouar
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Midttun, Oivind
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Steffen, Annika
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Dossus, Laure
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Boutron-Ruault, ...
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show more...
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Severi, Gianluca
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Kuehn, Tilman
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Katzke, Verena
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Alonso de la Tor ...
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Gonzalez, Carlos ...
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Sanchez, Maria-J ...
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Dorronsoro, Mire ...
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Santiuste, Carme ...
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Barricarte, Aure ...
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Khaw, Kay-Tee
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Wareham, Nick
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Travis, Ruth C.
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Trichopoulou, An ...
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Giotaki, Maria
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Trichopoulos, Di ...
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Palli, Domenico
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Krogh, Vittorio
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Tumino, Rosario
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Vineis, Paolo
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Panico, Salvator ...
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Tjonneland, Anne
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Olsen, Anja
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Bueno-de-Mesquit ...
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Peeters, Petra H ...
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Ljungberg, Börje
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Wennberg, Maria
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Weiderpass, Elis ...
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Murphy, Neil
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Riboli, Elio
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Ueland, Per Magn ...
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Boeing, Heiner
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Brennan, Paul
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Johansson, Matti ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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American Journal ...
- By the university
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Umeå University
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Karolinska Institutet