Inherited Ataxia and Intrathecal Baclofen for the Treatment of Spasticity and Painful Spasms

Berntsson, Shala G., 1964- (author): Uppsala universitet,Landtblom: Neurovetenskap,Uppsala Univ, Sweden

Gauffin, Helena, 1964- (author): Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping

Melberg, Atle (author): Uppsala universitet,Landtblom: Neurovetenskap,Uppsala Univ, Sweden

Holtz, Anders (author): Uppsala universitet,Enblad: Neurokirurgi,Uppsala Univ, Sweden

Landtblom, Anne-Marie (author): Linköpings universitet,Uppsala universitet,Landtblom: Neurovetenskap,Univ Linköping, Med Fac, Dept Clin & Expt Med, Neurol, Linköping, Sweden,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping,Uppsala Univ, Sweden

(creator_code:org_t)

2019-03-14
2019
English.
In: Stereotactic and Functional Neurosurgery. - : S. Karger AG. - 1011-6125 .- 1423-0372. ; 97:1, s. 18-23

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; https://urn.kb.se/re...; show less...

Abstract Subject headings

Background: Intrathecal baclofen (ITB) treatment is considered a powerful tool in the management of severe spasticity in neurological conditions such as multiple sclerosis, cerebral palsy, and traumatic spinal cord and brain injury.Objectives: The objective of this study was to assess the effectiveness of the ITB in patients with inherited ataxia suffering from severe painful spasms and/or spasticity.Method: A total of 5 patients with spinocerebellar ataxia 3 or 7 or Friedreich's ataxia were included in this observational multicenter study. The patients were interviewed and completed outcome measures assessing pain (The Brief Pain Inventory), fatigue (Fatigue Severity Scale), and life satisfaction (LiSAT-9) before and 1 year after the treatment. Spasticity (Modified Ashworth Scale) and spasm frequency (SPFS) were measured objectively for each patient.Results: The mean treatment time was 1.9 years. Evaluation of established standard forms revealed symptomatic relief from spasticity, spasms, pain, and fatigue in addition to improved body posture, sleep, and life satisfaction after ITB treatment.Conclusions: We report the potential beneficial effects of ITB treatment in patients with inherited ataxia who also suffer from spasticity/spasms. ITB treatment indication in neurological disorders allows for extension to the treatment of spasticity/spasms in patients with hereditary ataxia.

By the author/editor: Berntsson, Shala ...; Gauffin, Helena, ...; Melberg, Atle; Holtz, Anders; Landtblom, Anne- ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

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