Aggrecan degradation in osteoarthritis and rheumatoid arthritis

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Sökning: L773:1745 3674 OR L773:1745 3682 > (1995-1999) > Aggrecan degradatio...

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Fältnamn	Indikatorer	Metadata
000		03277naa a2200325 4500
001		oai:lup.lub.lu.se:42f61329-e53f-46dd-b6f4-83ec15791c65
003		SwePub
008		160504s1995 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/42f61329-e53f-46dd-b6f4-83ec15791c652 URI
024	7	a https://doi.org/10.3109/174536795091576602 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Lark, Michael W.u University of Cincinnati4 aut
245	1 0	a Aggrecan degradation in osteoarthritis and rheumatoid arthritis
264		c 2009-07-08
264	1	b Informa UK Limited,c 1995
300		a 6 s.
520		a Aggrecan turnover is critically important to maintain extracellular matrix homeostasis in articular cartilage. Cartilage aggrecan metabolism has been studied in chondrocyte cell cultures, cartilage explant cultures, and in whole animal models. In many of these studies, matrix metalloproteinases (MMPs) are proposed to degrade cartilage aggrecan. MMP expression appears elevated in joint tissues from patients with osteoarthritis (OA) and rheumatoid arthritis (RA) (Dean et al. 1989, Wolfe et al. 1993) and inhibitors of both MMPs and thiol proteinases have been shown to block aggrecan (Buttle et al. 1992) and type II collagen (Mort et al. 1993) degradation in cartilage explant cultures. Using antibodies and cDNA probes, elevations in expression and concentration of many of these enzymes in animal models and in OA and RA have been described. Human cartilage aggrecan has now been cloned and sequenced (Doege et al. 1991). This information, in combination with the ability to sequence aggrecan and aggrecan fragments at the protein level, has resulted in the identification of several aggrecan fragments which appear to result from proteinase degradation. In this report, we describe data which suggest that MMPs may in part be responsible for aggrecan catabolism in normal articular cartilage, as well as in the elevated catabolism seen in OA and RA.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
700	1	a Bayne, Ellen K.u University of Cincinnati4 aut
700	1	a Lohmander, L. Stefanu Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund OsteoArthritis Division - Nedbrytning av ledbrosk: en biologisk process som leder till artros,Forskargrupper vid Lunds universitet,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund OsteoArthritis Division - Molecular marker research group,Lund University Research Groups4 aut0 (Swepub:lu)ort-slo
710	2	a University of Cincinnatib Ortopedi, Lund4 org
773	0	t Acta Orthopaedicad : Informa UK Limitedg 66:S266, s. 92-97q 66:S266<92-97x 1745-3674x 0001-6470
856	4	u http://dx.doi.org/10.3109/17453679509157660y FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/42f61329-e53f-46dd-b6f4-83ec15791c65
856	4 8	u https://doi.org/10.3109/17453679509157660

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