Conclusiveness resolves the conflict between quality of evidence and imprecision in GRADE

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Anttila, Sten (författare): Swedish Agency for Health Technology Assessment and Assessment of Social Services

Persson, Johannes (författare): Lund University,Lunds universitet,Teoretisk filosofi,Filosofiska institutionen,Institutioner,Humanistiska och teologiska fakulteterna,Theoretical Philosophy,Department of Philosophy,Departments,Joint Faculties of Humanities and Theology

Vareman, Niklas (författare): Lund University,Lunds universitet,Medicinsk etik,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Ethics,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine

Sahlin, Nils-Eric (författare): Lund University,Lunds universitet,Medicinsk etik,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Ethics,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine

(creator_code:org_t)

Elsevier BV, 2016
2016
Engelska 5 s.
Ingår i: Journal of Clinical Epidemiology. - : Elsevier BV. - 1878-5921 .- 0895-4356. ; 2016:75, s. 1-5

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Abstract Ämnesord

Stäng

The objective of our article is to show how “quality of evidence” and “imprecision,” as they are defined in Grading of Recommendations Assessment, Development, and Evaluation (GRADE) articles, may lead to confusion. We focus only on the context of systematic reviews.

ObjectivesThe objective of our article is to show how “quality of evidence” and “imprecision,” as they are defined in Grading of Recommendations Assessment, Development, and Evaluation (GRADE) articles, may lead to confusion. We focus only on the context of systematic reviews.Study Design and SettingWe analyze, with the aid of standard probabilistic and statistical concepts, the concepts of quality of evidence and imprecision as used in the GRADE framework. This enables us to point out some weaknesses in the relation between “quality of evidence” and “imprecision.”ResultsThe GRADE framework contains terms familiar from classical statistics, but these terms are used in nonstandard ways. Notably, “imprecision” does not have the meaning in the GRADE framework that it has in statistics, and the well-known table of “evidence levels” wrongly suggests that “quality of evidence” and “accuracy” express the same concept—they do not.ConclusionWe believe that “conclusiveness” rather than “imprecision” would be a suitable term to use when the question whether the CI excludes or includes certain critical margins is being addressed. Conclusiveness could also replace quality of evidence as the final step for a systematic reviewer.

Av författaren/redakt...: Anttila, Sten; Persson, Johanne ...; Vareman, Niklas; Sahlin, Nils-Eri ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Medicinsk etik

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