Sökning: L773:1942 0080 > Four-Group Classifi...
Fältnamn | Indikatorer | Metadata |
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000 | 03747naa a2200409 4500 | |
001 | oai:DiVA.org:umu-90857 | |
003 | SwePub | |
008 | 140701s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-908572 URI |
024 | 7 | a https://doi.org/10.1161/CIRCIMAGING.113.0012752 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Bang, Casper N.4 aut |
245 | 1 0 | a Four-Group Classification of Left Ventricular Hypertrophy Based on Ventricular Concentricity and Dilatation Identifies a Low-Risk Subset of Eccentric Hypertrophy in Hypertensive Patients |
264 | 1 | c 2014 |
338 | a print2 rdacarrier | |
520 | a Background-Left ventricular hypertrophy (LVH; high LV mass [LVM]) is traditionally classified as concentric or eccentric based on LV relative wall thickness. We evaluated the prediction of subsequent adverse events in a new 4-group LVH classification based on LV dilatation (high LV end-diastolic volume [EDV] index) and concentricity (mass/end-diastolic volume [M/EDV](2/3)) in hypertensive patients. Methods and Results-In the Losartan Intervention for Endpoint Reduction (LIFE) echocardiography substudy, 939 hypertensive patients with measurable LVM at baseline were randomized to a mean of 4.8 years of losartan- or atenolol-based treatment. Patients with LVH (LVM/body surface area >= 116 and >= 96 g/m(2) in men and woman, respectively) were divided into 4 groups-concentric nondilated (increased M/EDV, normal EDV), eccentric dilated (increased EDV, normal M/EDV), concentric dilated (increased M/EDV and EDV), and eccentric nondilated (normal M/EDV and EDV)-and compared with patients with normal LVM. Time-varying LVH classes were tested for association with all-cause and cardiovascular mortality and a composite end point of myocardial infarction, stroke, heart failure, and cardiovascular death in multivariable Cox analyses. At baseline, the LVs were categorized as eccentric nondilated in 12%, eccentric dilated in 20%, concentric nondilated in 29%, concentric dilated in 14%, and normal LVM in 25%. Treatment changed the prevalence of 4 LVH groups to 23%, 4%, 5%, and 7%; 62% had normal LVM after 4 years. In time-varying Cox analyses, compared with normal LVM, those with eccentric dilated and both concentric nondilated and dilated LVH had increased risks of all-cause or cardiovascular mortality or the composite end point, whereas the eccentric nondilated group did not. Conclusions-Hypertensive patients with relatively mild LVH without either increased LV volume or concentricity have similar risk of all-cause mortality or cardiovascular events because hypertensive patients with normal LVM seem to be a low-risk group. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a hypertension | |
653 | a hypertrophy | |
653 | a left ventricular geometry | |
700 | 1 | a Gerdts, Eva4 aut |
700 | 1 | a Aurigemma, Gerard P.4 aut |
700 | 1 | a Boman, Kurtu Umeå universitet,Medicin4 aut0 (Swepub:umu)kubo0001 |
700 | 1 | a de Simone, Giovanni4 aut |
700 | 1 | a Dahlof, Bjorn4 aut |
700 | 1 | a Kober, Lars4 aut |
700 | 1 | a Wachtell, Kristian4 aut |
700 | 1 | a Devereux, Richard B.4 aut |
710 | 2 | a Umeå universitetb Medicin4 org |
773 | 0 | t Circulation Cardiovascular Imagingg 7:3, s. 422-429q 7:3<422-429x 1941-9651x 1942-0080 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-90857 |
856 | 4 8 | u https://doi.org/10.1161/CIRCIMAGING.113.001275 |
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