SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(ADEM A)
 

Search: WFRF:(ADEM A) > (2020-2023) > Identification of G...

Identification of Genetic Variation Influencing Metformin Response in a Multiancestry Genome-Wide Association Study in the Diabetes Prevention Program (DPP)

Li, Josephine H. (author)
Massachusetts General Hospital,Broad Institute,Harvard Medical School
Perry, James A. (author)
University of Maryland School of Medicine
Jablonski, Kathleen A. (author)
George Washington University
show more...
Srinivasan, Shylaja (author)
University of California, San Francisco
Chen, Ling (author)
Massachusetts General Hospital,Broad Institute
Todd, Jennifer N. (author)
Boston Children's Hospital,Broad Institute,Massachusetts General Hospital
Harden, Maegan (author)
Broad Institute
Mercader, Josep M. (author)
Massachusetts General Hospital,Harvard Medical School,Broad Institute
Pan, Qing (author)
George Washington University
Dawed, Adem Y. (author)
University of Dundee
Yee, Sook Wah (author)
University of California, San Francisco
Pearson, Ewan R. (author)
University of Dundee
Giacomini, Kathleen M. (author)
University of California, San Francisco
Giri, Ayush (author)
Vanderbilt University Medical Center
Hung, Adriana M. (author)
Vanderbilt University Medical Center
Xiao, Shujie (author)
Henry Ford Health System
Williams, L. Keoki (author)
Henry Ford Health System
Franks, Paul W. (author)
Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
Hanson, Robert L. (author)
National Institute of Diabetes and Digestive and Kidney Diseases
Kahn, Steven E. (author)
Washington University School of Medicine
Knowler, William C. (author)
National Institute of Diabetes and Digestive and Kidney Diseases
Pollin, Toni I. (author)
University of Maryland School of Medicine
Florez, Jose C. (author)
Massachusetts General Hospital,Broad Institute,Harvard Medical School
show less...
 (creator_code:org_t)
2022-12-16
2023
English 12 s.
In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 72:8, s. 1161-1172
Related links:
http://dx.doi.org/10... (free)
show more...
https://lup.lub.lu.s...
https://doi.org/10.2...
show less...
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Genome-wide significant loci for metformin response in type 2 diabetes reported elsewhere have not been repli-cated in the Diabetes Prevention Program (DPP). To as-sess pharmacogenetic interactions in prediabetes, we conducted a genome-wide association study (GWAS) in the DPP. Cox proportional hazards models tested associations with diabetes incidence in the metformin (MET; n = 876) and placebo (PBO; n = 887) arms. Multiple linear regression assessed association with 1-year change in metformin-related quantitative traits, adjusted for baseline trait, age, sex, and 10 ancestry principal compo-nents. We tested for gene-by-treatment interaction. No significant associations emerged for diabetes inci-dence. We identified four genome-wide significant variants after correcting for correlated traits (P < 9 × 1029). In the MET arm, rs144322333 near ENOSF1 (minor al-lele frequency [MAF]AFR = 0.07; MAFEUR = 0.002) was associated with an increase in percentage of glycated hemoglobin (per minor allele, b = 0.39 [95% CI 0.28, 0.50]; P = 2.8 × 10212). rs145591055 near OMSR (MAF = 0.10 in American Indians) was associated with weight loss (kilograms) (per G allele, b = 27.55 [95% CI 29.88, 25.22]; P = 3.2 × 10210) in the MET arm. Neither variant was significant in PBO; gene-by-treatment interaction was significant for both variants [P(G×T) < 1.0 × 1024 ]. Replication in individuals with diabetes did not yield significant findings. A GWAS for metformin response in prediabetes revealed novel ethnic-specific associations that require further investigation but may have implications for tailored therapy.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Publication and Content Type

art (subject category)
ref (subject category)

Find in a library

  • Diabetes (Search for host publication in LIBRIS)

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view