WFRF:(Aare Sudhakar)
Sökning: WFRF:(Aare Sudhakar) > The role of sepsis ...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03637naa a2200397 4500 | |
| 001 | oai:DiVA.org:uu-180380 | |
| 003 | SwePub | |
| 008 | 120905s2012 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:125349417 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1803802 URI |
| 024 | 7 | a https://doi.org/10.1152/physiolgenomics.00031.20122 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1253494172 URI |
| 040 | a (SwePub)uud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Aare, Sudhakaru Uppsala universitet,Klinisk neurofysiologi4 aut0 (Swepub:uu)sudaa881 |
| 245 | 1 0 | a The role of sepsis in the development of limb muscle weakness in a porcine intensive care unit model |
| 264 | 1 | b American Physiological Society,c 2012 |
| 338 | a print2 rdacarrier | |
| 520 | a Severe muscle wasting and loss of muscle function in critically ill mechanically ventilated intensive care unit (ICU) patients have significant negative consequences on their recovery and rehabilitation that persist long after their hospital discharge; moreover the underlying mechanisms are unclear. Mechanical ventilation (MV) and immobilization-induced modifications play an important role in these consequences, including endotoxin induced sepsis. The present study aims to investigate how sepsis aggravates ventilator and immobilization-related limb muscle dysfunction. Hence, biceps femoris muscle gene expression was investigated in pigs exposed to ICU intervention, i.e., immobilization, sedation, and MV, alone or in combination with sepsis for five days. In previous studies, we have shown that ICU intervention alone or in combination with sepsis did not affect muscle fiber size on day 5, but a significant decrease was observed in single fiber maximal force normalized to cross-sectional area (specific force) when sepsis was added to the ICU intervention. According to microarray data, the addition of sepsis to the ICU intervention induced a deregulation of more than 500 genes, such as an increased expression of genes involved in chemokine activity, kinase activity and transcriptional regulation. Genes involved in the regulation of the oxidative stress response, cytoskeletal/sarcomeric and heat shock proteins were on the other hand down-regulated when sepsis was added to the ICU intervention. Thus, sepsis has a significant negative effect on muscle function in critically ill ICU patients and chemokine activity and heat shock protein genes are forwarded to play an instrumental role in this specific muscle wasting condition. | |
| 653 | a Sepsis | |
| 653 | a porcine | |
| 653 | a muscle wasting | |
| 653 | a intensive care | |
| 700 | 1 | a Radell, Peteru Karolinska Institutet4 aut |
| 700 | 1 | a Eriksson, Larsu Karolinska Institutet4 aut |
| 700 | 1 | a Chen, Yi-Wenu Research center for genetic medicine,children national medical center washington4 aut |
| 700 | 1 | a Hoffman, Eric Pu Research center for genetic medicine,children national medical center washington4 aut |
| 700 | 1 | a Larsson, Larsu Uppsala universitet,Klinisk neurofysiologi4 aut0 (Swepub:uu)lalar021 |
| 710 | 2 | a Uppsala universitetb Klinisk neurofysiologi4 org |
| 773 | 0 | t Physiological Genomicsd : American Physiological Societyg 44:18, s. 865-877q 44:18<865-877x 1094-8341x 1531-2267 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-180380 |
| 856 | 4 8 | u https://doi.org/10.1152/physiolgenomics.00031.2012 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:125349417 |
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- Aare, Sudhakar
- Radell, Peter
- Eriksson, Lars
- Chen, Yi-Wen
- Hoffman, Eric P
- Larsson, Lars
- Artiklar i publikationen
- Physiological Ge ...
- Av lärosätet
- Uppsala universitet
- Karolinska Institutet
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