WFRF:(Agardh Daniel)
Sökning: WFRF:(Agardh Daniel) > HLA-DQB1*0201/0302 ...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04222naa a2200433 4500 | |
| 001 | oai:lup.lub.lu.se:95362067-c7d2-43e7-a61a-f11f4424608e | |
| 003 | SwePub | |
| 008 | 160401s1996 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/11102752 URI |
| 024 | 7 | a https://doi.org/10.1007/s0012500505752 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Agardh, Danielu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Pediatrisk endokrinologi,Celiac Disease and Diabetes Unit,Lund University Research Groups,Paediatric Endocrinology4 aut0 (Swepub:lu)med-dia |
| 245 | 1 0 | a HLA-DQB1*0201/0302 is associated with severe retinopathy in patients with IDDM |
| 264 | 1 | b Springer Science and Business Media LLC,c 1996 |
| 520 | a Some insulin-dependent diabetic (IDDM) patients develop severe forms of retinopathy. Putative risk factors such as hypertension, poor metabolic control, nephropathy and growth hormone levels do not fully explain the progress of retinopathy in these patients. It has been discussed whether there is a genetic marker, since some diabetic patients without any known predisposing risk factors develop severe retinopathy and others do not. In the present study, HLA-DR and DQ were compared in two patient groups with IDDM. One group consisted of patients with early-onset diabetes, with severe non-proliferative or proliferative retinopathy; the other group had no or only mild signs of retinopathy. High resolution HLA typing was carried out by polymerase chain reaction (PCR) and hybridization with allele specific probes. Alleles on the DR3-DQ2 haplotype, DRB1*0301, DQA1*0501 and DQB1*0201, were more frequent in patients with severe retinopathy. A difference was seen when combining certain alleles in the genotypes of DQA1*03/0501 (p > 0.05) and DQB1*0201/0302 (p < 0.01). The findings of the present study suggest that DQB1*0201/0302 is the strongest genetic marker for severe retinopathy and DRB1*0301/0401 only has a secondary influence when combined with this genotype. It seems as if IDDM patients who are positive for the genotype DR3-DQ2/DR4-DQ8 (DRB1*0301-DQA1*0501-DQB1*0201/DRB1*0401 -DQA1*03-DQB1*0302) are at greater risk of developing severe retinopathy. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 653 | a Severe retinopathy | |
| 653 | a insulin-dependent diabetes mellitus | |
| 653 | a HLA-DR | |
| 653 | a HLA-DQ | |
| 653 | a allele | |
| 653 | a haplotype | |
| 653 | a genotype | |
| 700 | 1 | a Gaur, L K4 aut |
| 700 | 1 | a Agardh, Elisabetu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine4 aut0 (Swepub:lu)ofta-eag |
| 700 | 1 | a Landin-Olsson, Monau Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-mla |
| 700 | 1 | a Agardh, Carl-Davidu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine4 aut0 (Swepub:lu)endo-cag |
| 700 | 1 | a Lernmark, Åkeu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 aut0 (Swepub:lu)endo-ale |
| 710 | 2 | a Celiaki och diabetesb Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Diabetologiad : Springer Science and Business Media LLCg 39:11, s. 1313-1317q 39:11<1313-1317x 1432-0428x 0012-186X |
| 856 | 4 | u http://dx.doi.org/10.1007/s001250050575y FULLTEXT |
| 856 | 4 | u https://link.springer.com/content/pdf/10.1007%2Fs001250050575.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1110275 |
| 856 | 4 8 | u https://doi.org/10.1007/s001250050575 |
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