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Not all IGHV3-21 ch...
Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations.
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- Baliakas, Panagiotis (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi
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Agathangelidis, Andreas (author)
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- Hadzidimitriou, Anastasia (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi
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- Sutton, Lesley-Ann (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi
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Minga, Eva (author)
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Tsanousa, Athina (author)
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Scarfò, Lydia (author)
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Davis, Zadie (author)
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Yan, Xiao-Jie (author)
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Shanafelt, Tait (author)
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Plevova, Karla (author)
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Sandberg, Yorick (author)
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Vojdeman, Fie Juhl (author)
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Boudjogra, Myriam (author)
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Tzenou, Tatiana (author)
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Chatzouli, Maria (author)
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Chu, Charles C (author)
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Veronese, Silvio (author)
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Gardiner, Anne (author)
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- Mansouri, Larry (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi
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- Smedby, Karin E (author)
- Karolinska Institutet
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Pedersen, Lone Bredo (author)
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Moreno, Denis (author)
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Van Lom, Kirsten (author)
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Giudicelli, Véronique (author)
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Francova, Hana Skuhrova (author)
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Nguyen-Khac, Florence (author)
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Panagiotidis, Panagiotis (author)
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- Juliusson, Gunnar (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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Angelis, Lefteris (author)
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Anagnostopoulos, Achilles (author)
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Lefranc, Marie-Paule (author)
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Facco, Monica (author)
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Trentin, Livio (author)
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Catherwood, Mark (author)
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Montillo, Marco (author)
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Geisler, Christian H (author)
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Langerak, Anton W (author)
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Pospisilova, Sarka (author)
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Chiorazzi, Nicholas (author)
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Oscier, David (author)
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Jelinek, Diane F (author)
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Darzentas, Nikos (author)
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Belessi, Chrysoula (author)
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Davi, Frederic (author)
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Ghia, Paolo (author)
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- Rosenquist, Richard Brandell (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi
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- Stamatopoulos, Kostas (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi
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(creator_code:org_t)
- American Society of Hematology, 2015
- 2015
- English.
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In: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 125:5, s. 856-859
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://ashpublicati...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- An unresolved issue in chronic lymphocytic leukemia (CLL) is whether IGHV3-21 gene usage, in general, or the expression of stereotyped B-cell receptor immunoglobulin defining subset #2 (IGHV3-21/IGLV3-21), in particular, determines outcome for IGHV3-21-utilizing cases. We reappraised this issue in 8593 CLL patients of whom 437 (5%) used the IGHV3-21 gene with 254/437 (58%) classified as subset #2. Within subset #2, immunoglobulin heavy variable (IGHV)-mutated cases predominated, whereas non-subset #2/IGHV3-21 was enriched for IGHV-unmutated cases (P = .002). Subset #2 exhibited significantly shorter time-to-first-treatment (TTFT) compared with non-subset #2/IGHV3-21 (22 vs 60 months, P = .001). No such difference was observed between non-subset #2/IGHV3-21 vs the remaining CLL with similar IGHV mutational status. In conclusion, IGHV3-21 CLL should not be axiomatically considered a homogeneous entity with adverse prognosis, given that only subset #2 emerges as uniformly aggressive, contrasting non-subset #2/IGVH3-21 patients whose prognosis depends on IGHV mutational status as the remaining CLL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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Blood
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To the university's database
- By the author/editor
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Baliakas, Panagi ...
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Agathangelidis, ...
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Hadzidimitriou, ...
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Sutton, Lesley-A ...
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Minga, Eva
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Tsanousa, Athina
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show more...
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Scarfò, Lydia
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Davis, Zadie
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Yan, Xiao-Jie
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Shanafelt, Tait
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Plevova, Karla
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Sandberg, Yorick
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Vojdeman, Fie Ju ...
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Boudjogra, Myria ...
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Tzenou, Tatiana
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Chatzouli, Maria
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Chu, Charles C
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Veronese, Silvio
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Gardiner, Anne
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Mansouri, Larry
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Smedby, Karin E
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Pedersen, Lone B ...
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Moreno, Denis
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Van Lom, Kirsten
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Giudicelli, Véro ...
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Francova, Hana S ...
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Nguyen-Khac, Flo ...
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Panagiotidis, Pa ...
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Juliusson, Gunna ...
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Angelis, Lefteri ...
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Anagnostopoulos, ...
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Lefranc, Marie-P ...
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Facco, Monica
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Trentin, Livio
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Catherwood, Mark
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Montillo, Marco
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Geisler, Christi ...
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Langerak, Anton ...
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Pospisilova, Sar ...
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Chiorazzi, Nicho ...
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Oscier, David
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Jelinek, Diane F
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Darzentas, Nikos
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Belessi, Chrysou ...
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Davi, Frederic
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Ghia, Paolo
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Rosenquist, Rich ...
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Stamatopoulos, K ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Blood
- By the university
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Lund University
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Karolinska Institutet
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Uppsala University