Mass Spectrometry Proteomics Characterization of Plasma Biomarkers for Colorectal Cancer Associated With Inflammation

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Mass Spectrometry Proteomics Characterization of Plasma Biomarkers for Colorectal Cancer Associated With Inflammation

Urbiola-Salvador, Victor (författare): Univ Gdansk, Intercollegiate Fac Biotechnol, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.;Univ Gdansk, Med Univ Gdansk, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.

Jablonska, Agnieszka (författare): Univ Gdansk, Intercollegiate Fac Biotechnol, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.;Univ Gdansk, Med Univ Gdansk, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.

Miroszewska, Dominika (författare): Univ Gdansk, Intercollegiate Fac Biotechnol, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.;Univ Gdansk, Med Univ Gdansk, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.

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Kamysz, Weronika (författare): Univ Gdansk, Intercollegiate Fac Biotechnol, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.;Univ Gdansk, Med Univ Gdansk, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.

Duzowska, Katarzyna (författare): Univ Gdansk, Med Univ Gdansk, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.;Med Univ Gdansk, Med Lab 3P, Gdansk, Pomeranian, Poland.

Drezek-Chyla, Kinga (författare): Med Univ Gdansk, Med Lab 3P, Gdansk, Pomeranian, Poland.

Baber, Ronny (författare): Univ Leipzig, Inst Lab Med Clin Chem & Mol Diagnost, Univ Klinikum Leipzig, Leipzig, Saxony, Germany.;Univ Leipzig, Leipzig Med Biobank, Leipzig, Saxony, Germany.

Thieme, Rene (författare): Univ Hosp Leipzig, Dept Visceral Transplant Thorac & Vasc Surg, Leipzig, Saxony, Germany.

Gockel, Ines (författare): Univ Hosp Leipzig, Dept Visceral Transplant Thorac & Vasc Surg, Leipzig, Saxony, Germany.

Zdrenka, Marek (författare): Prof Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Tumor Pathol & Pathomorphol, Bydgoszcz, Kuyavian Pomera, Poland.

Srutek, Ewa (författare): Prof Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Tumor Pathol & Pathomorphol, Bydgoszcz, Kuyavian Pomera, Poland.

Szylberg, Lukasz (författare): Prof Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Tumor Pathol & Pathomorphol, Bydgoszcz, Kuyavian Pomera, Poland.;Nicolaus Copernicus Univ Torun, Dept Obstet Gynaecol & Oncol, Coll Med Bydgoszcz, Bydgoszcz, Kuyavian Pomera, Poland.

Jankowski, Michal (författare): Nicolaus Copernicus Univ, Surg Oncol, Ludw Rydygiers Coll Med, Torun, Kuyavian Pomera, Poland.;Prof Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Surg Oncol, Bydgoszcz, Kuyavian Pomera, Poland.

Bala, Dariusz (författare): Nicolaus Copernicus Univ, Surg Oncol, Ludw Rydygiers Coll Med, Torun, Kuyavian Pomera, Poland.;Prof Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Surg Oncol, Bydgoszcz, Kuyavian Pomera, Poland.

Zegarski, Wojciech (författare): Nicolaus Copernicus Univ, Surg Oncol, Ludw Rydygiers Coll Med, Torun, Kuyavian Pomera, Poland.;Prof Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Surg Oncol, Bydgoszcz, Kuyavian Pomera, Poland.;Specialist Hosp Koscierzyna, Clin Gen & Oncol Surg, Koscierzyna, Pomeranian, Poland.

Nowikiewicz, Tomasz (författare): Nicolaus Copernicus Univ, Surg Oncol, Ludw Rydygiers Coll Med, Torun, Kuyavian Pomera, Poland.;Prof Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Breast Canc & Reconstruct Surg, Bydgoszcz, Kuyavian Pomera, Poland.

Makarewicz, Wojciech (författare): Prof Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Breast Canc & Reconstruct Surg, Bydgoszcz, Kuyavian Pomera, Poland.

Adamczyk, Agnieszka (författare): Maria Sklodowska Curie Natl Res Inst Oncol, Dept Tumor Pathol, Krakow, Poland.

Ambicka, Aleksandra (författare): Maria Sklodowska Curie Natl Res Inst Oncol, Dept Tumor Pathol, Krakow, Poland.

Przewoznik, Marcin (författare): Maria Sklodowska Curie Natl Res Inst Oncol, Dept Tumor Pathol, Krakow, Poland.

Harazin-Lechowska, Agnieszka (författare): Maria Sklodowska Curie Natl Res Inst Oncol, Dept Tumor Pathol, Krakow, Poland.

Rys, Janusz (författare): Maria Sklodowska Curie Natl Res Inst Oncol, Dept Tumor Pathol, Krakow, Poland.

Macur, Katarzyna (författare): Univ Gdansk, Lab Mass Spectrometry, Core Facil Labs, Intercollegiate Fac Biotechnol, Gdansk, Pomeranian, Poland.

Czaplewska, Paulina (författare): Univ Gdansk, Med Univ Gdansk, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.;Univ Gdansk, Lab Mass Spectrometry, Core Facil Labs, Intercollegiate Fac Biotechnol, Gdansk, Pomeranian, Poland.

Filipowicz, Natalia (författare): Med Univ Gdansk, Med Lab 3P, Gdansk, Pomeranian, Poland.

Piotrowski, Arkadiusz (författare): Med Univ Gdansk, Med Lab 3P, Gdansk, Pomeranian, Poland.

Dumanski, Jan P. (författare): Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerprecisionsmedicin,Med Univ Gdansk, Med Lab 3P, Gdansk, Pomeranian, Poland.;Med Univ Gdansk, Dept Biol & Pharmaceut Bot, Gdansk, Pomeranian, Poland.

Chen, Zhi (författare): Univ Gdansk, Intercollegiate Fac Biotechnol, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.;Univ Gdansk, Med Univ Gdansk, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.;Univ Oulu, Fac Biochem & Mol Med, Oulu, Finland.

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Univ Gdansk, Intercollegiate Fac Biotechnol, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland;Univ Gdansk, Med Univ Gdansk, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland. Univ Gdansk, Med Univ Gdansk, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.;Med Univ Gdansk, Med Lab 3P, Gdansk, Pomeranian, Poland. (creator_code:org_t)

Sage Publications, 2024
2024
Engelska.
Ingår i: Biomarker Insights. - : Sage Publications. - 1177-2719. ; 19

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://uu.diva-port... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Background: Colorectal cancer (CRC) prognosis is determined by the disease stage with low survival rates for advanced stages. Current CRC screening programs are mainly using colonoscopy, limited by its invasiveness and high cost. Therefore, non-invasive, cost-effective, and accurate alternatives are urgently needed.Objective and design: This retrospective multi-center plasma proteomics study was performed to identify potential blood-based biomarkers in 36 CRC patients and 26 healthy volunteers by high-resolution mass spectrometry proteomics followed by the validation in an independent CRC cohort (60 CRC patients and 44 healthy subjects) of identified selected biomarkers.Results: Among the 322 identified plasma proteins, 37 were changed between CRC patients and healthy volunteers and were associated with the complement cascade, cholesterol metabolism, and SERPIN family members. Increased levels in CRC patients of the complement proteins C1QB, C4B, and C5 as well as pro-inflammatory proteins, lipopolysaccharide-binding protein (LBP) and serum amyloid A4, constitutive (SAA4) were revealed for first time. Importantly, increased level of C5 was verified in an independent validation CRC cohort. Increased C4B and C8A levels were correlated with cancer-associated inflammation and CRC progression, while cancer-associated inflammation was linked to the acute-phase reactant leucine-rich alpha-2-glycoprotein 1 (LRG1) and ceruloplasmin. Moreover, a 4-protein signature including C4B, C8A, apolipoprotein C2 (APO) C2, and immunoglobulin heavy constant gamma 2 was changed between early and late CRC stages.Conclusion: Our results suggest that C5 could be a potential biomarker for CRC diagnosis. Further validation studies will aid the application of these new potential biomarkers to improve CRC diagnosis and patient care.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Plasma proteomics
colorectal cancer
biomarker
mass spectrometry
complement cascade
diagnosis
inflammation
cancer progression

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