Genome-wide association study identifies new prostate cancer susceptibility loci

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Andriole Gerald L) > Genome-wide associa...

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		05300naa a2201057 4500
001		oai:DiVA.org:umu-47641
003		SwePub
008		110927s2011 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:123200258
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-476412 URI
024	7	a https://doi.org/10.1093/hmg/ddr2952 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1232002582 URI
040		a (SwePub)umud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Schumacher, Fredrick R.4 aut
245	1 0	a Genome-wide association study identifies new prostate cancer susceptibility loci
264		c 2011-07-08
264	1	a London :b IRL Press,c 2011
338		a print2 rdacarrier
520		a Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countries and the second leading cause of cancer mortality, yet little is known regarding its etiology and factors that influence clinical outcome. Genome-wide association studies (GWAS) of PrCa have identified at least 30 distinct loci associated with small differences in risk. We conducted a GWAS in 2782 advanced PrCa cases (Gleason grade >= 8 or tumor stage C/D) and 4458 controls with 571 243 single nucleotide polymorphisms (SNPs). Based on in silico replication of 4679 SNPs (Stage 1, P < 0.02) in two published GWAS with 7358 PrCa cases and 6732 controls, we identified a new susceptibility locus associated with overall PrCa risk at 2q37.3 (rs2292884, P = 4.3 x 10(-8)). We also confirmed a locus suggested by an earlier GWAS at 12q13 (rs902774, P = 8.6 x 10(-9)). The estimated per-allele odds ratios for these loci (1.14 for rs2292884 and 1.17 for rs902774) did not differ between advanced and non-advanced PrCa (case-only test for heterogeneity P = 0.72 and P = 0.61, respectively). Further studies will be needed to assess whether these or other loci are differentially associated with PrCa subtypes.
650	7	a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng
700	1	a Berndt, Sonja I.4 aut
700	1	a Siddiq, Afshan4 aut
700	1	a Jacobs, Kevin B.4 aut
700	1	a Wang, Zhaoming4 aut
700	1	a Lindstrom, Sara4 aut
700	1	a Stevens, Victoria L.4 aut
700	1	a Chen, Constance4 aut
700	1	a Mondul, Alison M.4 aut
700	1	a Travis, Ruth C.4 aut
700	1	a Stram, Daniel O.4 aut
700	1	a Eeles, Rosalind A.4 aut
700	1	a Easton, Douglas F.4 aut
700	1	a Giles, Graham4 aut
700	1	a Hopper, John L.4 aut
700	1	a Neal, David E.4 aut
700	1	a Hamdy, Freddie C.4 aut
700	1	a Donovan, Jenny L.4 aut
700	1	a Muir, Kenneth4 aut
700	1	a Al Olama, Ali Amin4 aut
700	1	a Kote-Jarai, Zsofia4 aut
700	1	a Guy, Michelle4 aut
700	1	a Severi, Gianluca4 aut
700	1	a Gronberg, Henriku Karolinska Institutet4 aut
700	1	a Isaacs, William B.4 aut
700	1	a Karlsson, Robertu Karolinska Institutet4 aut
700	1	a Wiklund, Fredriku Karolinska Institutet4 aut
700	1	a Xu, Jianfeng4 aut
700	1	a Allen, Naomi E.4 aut
700	1	a Andriole, Gerald L.4 aut
700	1	a Barricarte, Aurelio4 aut
700	1	a Boeing, Heiner4 aut
700	1	a Bueno-de-Mesquita, H. Bas4 aut
700	1	a Crawford, E. David4 aut
700	1	a Diver, W. Ryan4 aut
700	1	a Gonzalez, Carlos A.4 aut
700	1	a Gaziano, J. Michael4 aut
700	1	a Giovannucci, Edward L.4 aut
700	1	a Johansson, Mattiasu Umeå universitet,Urologi och andrologi,International Agency for Research on Cancer (IARC), Lyon, France4 aut0 (Swepub:umu)masmas97
700	1	a Le Marchand, Loic4 aut
700	1	a Ma, Jing4 aut
700	1	a Sieri, Sabina4 aut
700	1	a Stattin, Päru Umeå universitet,Urologi och andrologi4 aut0 (Swepub:umu)past0003
700	1	a Stampfer, Meir J.4 aut
700	1	a Tjonneland, Anne4 aut
700	1	a Vineis, Paolo4 aut
700	1	a Virtamo, Jarmo4 aut
700	1	a Vogel, Ulla4 aut
700	1	a Weinstein, Stephanie J.4 aut
700	1	a Yeager, Meredith4 aut
700	1	a Thun, Michael J.4 aut
700	1	a Kolonel, Laurence N.4 aut
700	1	a Henderson, Brian E.4 aut
700	1	a Albanes, Demetrius4 aut
700	1	a Hayes, Richard B.4 aut
700	1	a Feigelson, Heather Spencer4 aut
700	1	a Riboli, Elio4 aut
700	1	a Hunter, David J.4 aut
700	1	a Chanock, Stephen J.4 aut
700	1	a Haiman, Christopher A.4 aut
700	1	a Kraft, Peter4 aut
710	2	a Karolinska Institutetb Urologi och andrologi4 org
773	0	t Human Molecular Geneticsd London : IRL Pressg 20:19, s. 3867-3875q 20:19<3867-3875x 0964-6906x 1460-2083
856	4	u https://academic.oup.com/hmg/article-pdf/20/19/3867/17252879/ddr295.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-47641
856	4 8	u https://doi.org/10.1093/hmg/ddr295
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:123200258

Hitta via bibliotek

Human Molecular Genetics (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Schumacher, Fred ...; Berndt, Sonja I.; Siddiq, Afshan; Jacobs, Kevin B.; Wang, Zhaoming; Lindstrom, Sara; visa fler...; Stevens, Victori ...; Chen, Constance; Mondul, Alison M ...; Travis, Ruth C.; Stram, Daniel O.; Eeles, Rosalind ...; Easton, Douglas ...; Giles, Graham; Hopper, John L.; Neal, David E.; Hamdy, Freddie C ...; Donovan, Jenny L ...; Muir, Kenneth; Al Olama, Ali Am ...; Kote-Jarai, Zsof ...; Guy, Michelle; Severi, Gianluca; Gronberg, Henrik; Isaacs, William ...; Karlsson, Robert; Wiklund, Fredrik; Xu, Jianfeng; Allen, Naomi E.; Andriole, Gerald ...; Barricarte, Aure ...; Boeing, Heiner; Bueno-de-Mesquit ...; Crawford, E. Dav ...; Diver, W. Ryan; Gonzalez, Carlos ...; Gaziano, J. Mich ...; Giovannucci, Edw ...; Johansson, Matti ...; Le Marchand, Loi ...; Ma, Jing; Sieri, Sabina; Stattin, Pär; Stampfer, Meir J ...; Tjonneland, Anne; Vineis, Paolo; Virtamo, Jarmo; Vogel, Ulla; Weinstein, Steph ...; Yeager, Meredith; Thun, Michael J.; Kolonel, Laurenc ...; Henderson, Brian ...; Albanes, Demetri ...; Hayes, Richard B ...; Feigelson, Heath ...; Riboli, Elio; Hunter, David J.; Chanock, Stephen ...; Haiman, Christop ...; Kraft, Peter; visa färre...

Om ämnet

NATURVETENSKAP: NATURVETENSKAP; och Biologi; och Biokemi och mole ...

Artiklar i publikationen: Human Molecular ...

Av lärosätet: Umeå universitet; Karolinska Institutet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se