onr:"swepub:oai:prod.swepub.kib.ki.se:132527774"
Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:132527774" > Meta-analysis of ge...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05890naa a2201465 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:132527774 | |
| 003 | SwePub | |
| 008 | 240829s2015 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1325277742 URI |
| 024 | 7 | a https://doi.org/10.1038/srep173692 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Cheng, THT4 aut |
| 245 | 1 0 | a Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1 |
| 264 | c 2015-12-01 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2015 |
| 520 | a High-risk mutations in several genes predispose to both colorectal cancer (CRC) and endometrial cancer (EC). We therefore hypothesised that some lower-risk genetic variants might also predispose to both CRC and EC. Using CRC and EC genome-wide association series, totalling 13,265 cancer cases and 40,245 controls, we found that the protective allele [G] at one previously-identified CRC polymorphism, rs2736100 near TERT, was associated with EC risk (odds ratio (OR) = 1.08, P = 0.000167); this polymorphism influences the risk of several other cancers. A further CRC polymorphism near TERC also showed evidence of association with EC (OR = 0.92; P = 0.03). Overall, however, there was no good evidence that the set of CRC polymorphisms was associated with EC risk and neither of two previously-reported EC polymorphisms was associated with CRC risk. A combined analysis revealed one genome-wide significant polymorphism, rs3184504, on chromosome 12q24 (OR = 1.10, P = 7.23 × 10−9) with shared effects on CRC and EC risk. This polymorphism, a missense variant in the gene SH2B3, is also associated with haematological and autoimmune disorders, suggesting that it influences cancer risk through the immune response. Another polymorphism, rs12970291 near gene TSHZ1, was associated with both CRC and EC (OR = 1.26, P = 4.82 × 10−8), with the alleles showing opposite effects on the risks of the two cancers. | |
| 700 | 1 | a Thompson, D4 aut |
| 700 | 1 | a Painter, J4 aut |
| 700 | 1 | a O'Mara, T4 aut |
| 700 | 1 | a Gorman, M4 aut |
| 700 | 1 | a Martin, L4 aut |
| 700 | 1 | a Palles, C4 aut |
| 700 | 1 | a Jones, A4 aut |
| 700 | 1 | a Buchanan, DD4 aut |
| 700 | 1 | a Win, AK4 aut |
| 700 | 1 | a Hopper, J4 aut |
| 700 | 1 | a Jenkins, M4 aut |
| 700 | 1 | a Lindor, NM4 aut |
| 700 | 1 | a Newcomb, PA4 aut |
| 700 | 1 | a Gallinger, S4 aut |
| 700 | 1 | a Conti, D4 aut |
| 700 | 1 | a Schumacher, F4 aut |
| 700 | 1 | a Casey, G4 aut |
| 700 | 1 | a Giles, GG4 aut |
| 700 | 1 | a Pharoah, P4 aut |
| 700 | 1 | a Peto, J4 aut |
| 700 | 1 | a Cox, A4 aut |
| 700 | 1 | a Swerdlow, A4 aut |
| 700 | 1 | a Couch, F4 aut |
| 700 | 1 | a Cunningham, JM4 aut |
| 700 | 1 | a Goode, EL4 aut |
| 700 | 1 | a Winham, SJ4 aut |
| 700 | 1 | a Lambrechts, D4 aut |
| 700 | 1 | a Fasching, P4 aut |
| 700 | 1 | a Burwinkel, B4 aut |
| 700 | 1 | a Brenner, H4 aut |
| 700 | 1 | a Brauch, H4 aut |
| 700 | 1 | a Chang-Claude, J4 aut |
| 700 | 1 | a Salvesen, HB4 aut |
| 700 | 1 | a Kristensen, V4 aut |
| 700 | 1 | a Darabi, H4 aut |
| 700 | 1 | a Li, JM4 aut |
| 700 | 1 | a Liu, T4 aut |
| 700 | 1 | a Lindblom, Au Karolinska Institutet4 aut |
| 700 | 1 | a Hall, Pu Karolinska Institutet4 aut |
| 700 | 1 | a de Polanco, ME4 aut |
| 700 | 1 | a Sans, M4 aut |
| 700 | 1 | a Carracedo, A4 aut |
| 700 | 1 | a Castellvi-Bel, S4 aut |
| 700 | 1 | a Rojas-Martinez, A4 aut |
| 700 | 1 | a Aguiar, S4 aut |
| 700 | 1 | a Teixeira, MR4 aut |
| 700 | 1 | a Dunning, AM4 aut |
| 700 | 1 | a Dennis, J4 aut |
| 700 | 1 | a Otton, G4 aut |
| 700 | 1 | a Proietto, T4 aut |
| 700 | 1 | a Holliday, E4 aut |
| 700 | 1 | a Attia, J4 aut |
| 700 | 1 | a Ashton, K4 aut |
| 700 | 1 | a Scott, RJ4 aut |
| 700 | 1 | a McEvoy, M4 aut |
| 700 | 1 | a Dowdy, SC4 aut |
| 700 | 1 | a Fridley, BL4 aut |
| 700 | 1 | a Werner, HMJ4 aut |
| 700 | 1 | a Trovik, J4 aut |
| 700 | 1 | a Njolstad, TS4 aut |
| 700 | 1 | a Tham, Eu Karolinska Institutet4 aut |
| 700 | 1 | a Mints, Mu Karolinska Institutet4 aut |
| 700 | 1 | a Runnebaum, I4 aut |
| 700 | 1 | a Hillemanns, P4 aut |
| 700 | 1 | a Dork, T4 aut |
| 700 | 1 | a Amant, F4 aut |
| 700 | 1 | a Schrauwen, S4 aut |
| 700 | 1 | a Hein, A4 aut |
| 700 | 1 | a Beckmann, MW4 aut |
| 700 | 1 | a Ekici, A4 aut |
| 700 | 1 | a Czene, Ku Karolinska Institutet4 aut |
| 700 | 1 | a Meindl, A4 aut |
| 700 | 1 | a Bolla, MK4 aut |
| 700 | 1 | a Michailidou, K4 aut |
| 700 | 1 | a Tyrer, JP4 aut |
| 700 | 1 | a Wang, Q4 aut |
| 700 | 1 | a Ahmed, S4 aut |
| 700 | 1 | a Healey, CS4 aut |
| 700 | 1 | a Shah, M4 aut |
| 700 | 1 | a Annibali, D4 aut |
| 700 | 1 | a Depreeuw, J4 aut |
| 700 | 1 | a Al-Tassan, NA4 aut |
| 700 | 1 | a Harris, R4 aut |
| 700 | 1 | a Meyer, BF4 aut |
| 700 | 1 | a Whiffin, N4 aut |
| 700 | 1 | a Hosking, FJ4 aut |
| 700 | 1 | a Kinnersley, B4 aut |
| 700 | 1 | a Farrington, SM4 aut |
| 700 | 1 | a Timofeeva, M4 aut |
| 700 | 1 | a Tenesa, A4 aut |
| 700 | 1 | a Campbell, H4 aut |
| 700 | 1 | a Haile, RW4 aut |
| 700 | 1 | a Hodgson, S4 aut |
| 700 | 1 | a Carvajal-Carmona, L4 aut |
| 700 | 1 | a Cheadle, JP4 aut |
| 700 | 1 | a Easton, D4 aut |
| 700 | 1 | a Dunlop, M4 aut |
| 700 | 1 | a Houlston, R4 aut |
| 700 | 1 | a Spurdle, A4 aut |
| 700 | 1 | a Tomlinson, I4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Scientific reportsd : Springer Science and Business Media LLCg 5, s. 17369-q 5<17369-x 2045-2322 |
| 856 | 4 | u https://www.nature.com/articles/srep17369.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:132527774 |
| 856 | 4 8 | u https://doi.org/10.1038/srep17369 |
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- Cheng, THT
- Thompson, D
- Painter, J
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- Palles, C
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- Buchanan, DD
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- Cox, A
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- Couch, F
- Cunningham, JM
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- Chang-Claude, J
- Salvesen, HB
- Kristensen, V
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