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Global effect of mo...
Global effect of modifiable risk factors on cardiovascular disease and mortality
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- Magnussen, Christina (författare)
- Center for Population Health Innovation, University Heart and Vascular Center Hamburg, Germany; University Medical Center Hamburg Eppendorf, Germany; German Center for Cardiovascular Research (DZHK) Partner Site Hamburg Kiel Lübeck, Germany
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- Melander, O. (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Leong, Darryl P. (författare)
- Department of Medicine (Cardiology), McMaster University, Hamilton, Canada
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- Alegre-Diaz, Jesus (författare)
- Experimental Medicine Research Unit, School of Medicine, National Autonomous University of Mexico, Mexico City, Mexico
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- Amouyel, Philippe (författare)
- Université de Lille, Inserm, Centre Hospitalier University de Lille, Institut Pasteur de Lille, UMR1167 RID-AGE Risk Factors and Molecular Determinants of Aging-Related Diseases, Epidemiology and Public Health Department, Lille, France
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- Aviles-Santa, Larissa (författare)
- Division of Clinical and Health Services Research, National Institute on Minority Health and Health Disparities, National Institutes of Health, MD, Bethesda, United States
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- De Bacquer, Dirk (författare)
- Department of Public Health and Primary Care, Ghent University, Ghent, Belgium
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- Ballantyne, Christie M. (författare)
- Department of Medicine, Baylor College of Medicine, TX, Houston, United States
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- Bernabé-Ortiz, Antonio (författare)
- Cronicas Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru
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- Bobak, Martin (författare)
- Department of Epidemiology and Public Health, University College London, London, United Kingdom
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- Brenner, Hermann (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, and Network Aging Research, Heidelberg University, Heidelberg, Germany
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- Carrillo-Larco, Rodrigo M. (författare)
- Emory Global Diabetes Research Center, Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, United States
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- De Lemos, James (författare)
- Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, TX, Dallas, United States
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- Dobson, Annette (författare)
- School of Public Health, University of Queensland, Brisbane, Australia
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- Dörr, Marcus (författare)
- Department of Internal Medicine B, University Medicine Greifswald, Dzhk Partner Site Greifswald, Greifswald, Germany
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- Donfrancesco, Chiara (författare)
- Department of Cardiovascular and Endocrine Metabolic Diseases and Aging, Istituto Superiore di Sanità, Rome, Italy
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- Drygas, Wojciech (författare)
- Department of Epidemiology, Cardiovascular Disease Prevention and Health Promotion, National Institute of Cardiology, Lazarski University, Warsaw, Poland
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- Dullaart, Robin P. (författare)
- Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
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- Engström, G. (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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- Ferrario, Marco M. (författare)
- Research Center in Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy
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- Ferrières, Jean (författare)
- Department of Cardiology, Inserm UMR1295, Toulouse Rangueil University Hospital, Toulouse, France
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- De Gaetano, Giovanni (författare)
- Department of Epidemiology and Prevention, Irccs Neuromed, Pozzilli, Italy
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- Goldbourt, Uri (författare)
- Department of Epidemiology, Tel Aviv University School of Public Health, Tel Aviv, Israel
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- Gonzalez, Clicerio (författare)
- Centro de Estudios en Diabetes, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Cuernavaca, Mexico
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- Grassi, Guido (författare)
- Clinica Medica, University of Milano Bicocca, Milan, Italy
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- Hodge, Allison M. (författare)
- Division of Cancer Epidemiology, Cancer Council Victoria, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Australia
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- Hveem, Kristian (författare)
- Hunt (Trøndelag Health Study) Research Center, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Trondheim, Norway
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- Iacoviello, Licia (författare)
- Research Center in Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy; Department of Epidemiology and Prevention, Irccs Neuromed, Pozzilli, Italy
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- Ikram, M. Kamran (författare)
- Department of Neurology, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands; Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands
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- Irazola, Vilma (författare)
- Department of Chronic Diseases, Institute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina
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- Jobe, Modou (författare)
- Medical Research Council Unit the Gambia, London School of Hygiene and Tropical Medicine, Banjul, Gambia
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- Jousilahti, Pekka (författare)
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
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- Kaleebu, Pontiano (författare)
- Medical Research Council Uganda Virus Research Institute, London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda
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- Kavousi, Maryam (författare)
- Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands
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- Kee, Frank (författare)
- The Centre for Public Health, Queens University Belfast, Belfast, United Kingdom
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- Khalili, Davood (författare)
- Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Iran
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- Koenig, Wolfgang (författare)
- Dzhk Partner Site Munich Heart Alliance, Technical University of Munich, Munich, Germany; German Heart Center, Technical University of Munich, Munich, Germany; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany; Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany
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- Kontsevaya, Anna (författare)
- National Research Center for Therapy and Preventive Medicine, Ministry of Healthcare of the Russian Federation, Moscow, Russian Federation
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- Kuulasmaa, Kari (författare)
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
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- Lackner, Karl J. (författare)
- Institute of Clinical Chemistry and Laboratory Medicine, Germany; University Medical Center of the Johannes Gutenberg University Mainz, Dzhk Partner Site Rhine Main, Mainz, Germany
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- Leistner, David M. (författare)
- University Heart and Vascular Center Frankfurt, Dzhk Partner Site Rhine Main, Frankfurt, Germany
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- Lind, Lars (författare)
- Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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- Linneberg, Allan (författare)
- Department of Clinical Medicine, Faculty of Health and Medical Sciences, Copenhagen, Denmark; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark
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- Lorenz, Thiess (författare)
- Center for Population Health Innovation, University Heart and Vascular Center Hamburg, Germany; University Medical Center Hamburg Eppendorf, Germany; German Center for Cardiovascular Research (DZHK) Partner Site Hamburg Kiel Lübeck, Germany
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- Lyngbakken, Magnus Nakrem (författare)
- Department of Cardiology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway; K.G. Jebsen Center for Cardiac Biomarkers, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
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- Malekzadeh, Reza (författare)
- Liver and Pancreaticobiliary Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; Digestive Oncology Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; Digestive Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
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- Malyutina, Sofia (författare)
- Research Institute of Internal and Preventive Medicine, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russian Federation
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- Mathiesen, Ellisiv B. (författare)
- Department of Clinical Medicine, University of Tromsø the Arctic University of Norway, Tromsø, Norway
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- Melander, Olle (författare)
- Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
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- Metspalu, Andres (författare)
- Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia
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- Miranda, J. Jaime (författare)
- Cronicas Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru; Sydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Australia
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- Moitry, Marie (författare)
- Department of Public Health, Strasbourg University Hospital, University of Strasbourg, Strasbourg, France
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- Mugisha, Joseph (författare)
- Medical Research Council Uganda Virus Research Institute, London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda
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- Nalini, Mahdi (författare)
- Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States; Digestive Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
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- Nambi, Vijay (författare)
- Michael E. DeBakey Veterans Affairs Hospital, Baylor College of Medicine, TX, Houston, United States
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- Ninomiya, Toshiharu (författare)
- Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
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- Oppermann, Karen (författare)
- School of Medicine, University of Passo Fundo, Passo Fundo, Brazil
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- D'Orsi, Eleonora (författare)
- Department of Public Health, Postgraduate Program in Public Health, Federal University of Santa Catarina, Florianopolis, Brazil
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- Pająk, Andrzej (författare)
- Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland
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- Palmieri, Luigi (författare)
- Department of Cardiovascular and Endocrine Metabolic Diseases and Aging, Istituto Superiore di Sanità, Rome, Italy
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- Panagiotakos, Demosthenes (författare)
- School of Health Sciences and Education, Harokopio University, Athens, Greece
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- Perianayagam, Arokiasamy (författare)
- National Council of Applied Economic Research, Delhi, India; International Institute for Population Sciences, Mumbai, India
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- Peters, Annette (författare)
- Dzhk Partner Site Munich Heart Alliance, Technical University of Munich, Munich, Germany; Institute for Medical Information Processing, Biometry, and Epidemiology, Medical Faculty, Ludwig Maximilians Universität München, Munich, Germany; German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD) Partner Site Munich Neuherberg, Neuherberg, Germany
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- Poustchi, Hossein (författare)
- Digestive Oncology Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; Digestive Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
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- Prentice, Andrew M. (författare)
- Medical Research Council Unit the Gambia, London School of Hygiene and Tropical Medicine, Banjul, Gambia
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- Prescott, Eva (författare)
- Department of Cardiology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
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- Risérus, Ulf (författare)
- Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Sweden
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- Salomaa, Veikko (författare)
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
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- Sans, Susana (författare)
- Catalan Department of Health, Barcelona, Spain,University Medical Center Hamburg-Eppendorf
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- Sakata, Satoko (författare)
- Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
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- Schöttker, Ben (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, and Network Aging Research, Heidelberg University, Heidelberg, Germany
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- Schutte, Aletta E. (författare)
- George Institute for Global Health, Sydney, Australia; School of Population Health, Kensington, Australia; Hypertension in Africa Research Team, South African Medical Research Council Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa
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- Sepanlou, Sadaf G. (författare)
- Digestive Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
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- Sharma, Sanjib Kumar (författare)
- Department of Internal Medicine, B.P. Koirala Institute of Health Sciences, Dharan, Nepal
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- Shaw, Jonathan E. (författare)
- Baker Heart and Diabetes Institute, Melbourne, Australia
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- Simons, Leon A. (författare)
- University of New South Wales, Kensington, Australia
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- Söderberg, Stefan (författare)
- Umeå universitet,Kardiologi,Avdelningen för medicin
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- Tamosiunas, Abdonas (författare)
- Laboratory of Population Studies, Institute of Cardiology, Department of Preventive Medicine, Faculty of Public Health, Lithuanian University of Health Sciences, Kaunas, Lithuania
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- Thorand, Barbara (författare)
- Institute for Medical Information Processing, Biometry, and Epidemiology, Medical Faculty, Ludwig Maximilians Universität München, Munich, Germany; German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD) Partner Site Munich Neuherberg, Neuherberg, Germany
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- Tunstall-Pedoe, Hugh (författare)
- Cardiovascular Epidemiology Unit, Institute of Cardiovascular Research, University of Dundee, Dundee, United Kingdom
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- Twerenbold, Raphael (författare)
- Center for Population Health Innovation, University Heart and Vascular Center Hamburg, Germany; University Medical Center Hamburg Eppendorf, Germany; German Center for Cardiovascular Research (DZHK) Partner Site Hamburg Kiel Lübeck, Germany
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- Vanuzzo, Diego (författare)
- Monica (Monitoring Cardiovascular Diseases) Friuli Study Group, Udine, Italy
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- Veronesi, Giovanni (författare)
- Research Center in Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy
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- Waibel, Julia (författare)
- Center for Population Health Innovation, University Heart and Vascular Center Hamburg, Germany; University Medical Center Hamburg Eppendorf, Germany; German Center for Cardiovascular Research (DZHK) Partner Site Hamburg Kiel Lübeck, Germany
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- Wannamethee, S. Goya (författare)
- Research Department of Primary Care and Population Health, University College London, London, United Kingdom
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- Watanabe, Masafumi (författare)
- Global Center of Excellence Program Study Group, Yamagata University School of Medicine, Yamagata, Japan
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- Wild, Philipp S. (författare)
- Preventive Cardiology and Preventive Medicine, Mainz, Germany; Clinical Epidemiology and Systems Medicine, Center for Thrombosis and Hemostasis, Mainz, Germany; University Medical Center of the Johannes Gutenberg University Mainz, Dzhk Partner Site Rhine Main, Mainz, Germany; Institute for Molecular Biology, Mainz, Germany
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- Yao, Yao (författare)
- China Center for Health Development Studies, National School of Development, Peking University, China; Key Laboratory of Epidemiology of Major Diseases, Peking University, Ministry of Education, Beijing, China
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- Zeng, Yi (författare)
- Center for Healthy Aging and Development Studies, National School of Development, Peking University, China; Center for the Study of Aging and Human Development and Geriatrics Division, Medical School of Duke University, NC, Durham, United States
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- Ziegler, Andreas (författare)
- Center for Population Health Innovation, University Heart and Vascular Center Hamburg, Germany; University Medical Center Hamburg Eppendorf, Germany; School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa; Cardio-CARE, Davos, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland
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- Blankenberg, Stefan (författare)
- Center for Population Health Innovation, University Heart and Vascular Center Hamburg, Germany; University Medical Center Hamburg Eppendorf, Germany; German Center for Cardiovascular Research (DZHK) Partner Site Hamburg Kiel Lübeck, Germany; Cardio-CARE, Davos, Switzerland
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(creator_code:org_t)
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et al
- Massachusetts Medical Society, 2023
- 2023
- Engelska.
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Ingår i: New England Journal of Medicine. - : Massachusetts Medical Society. - 0028-4793 .- 1533-4406. ; 389:14, s. 1273-1285
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background: Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.Methods: We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality.Results: Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6).Conclusions: Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. (Funded by the German Center for Cardiovascular Research (DZHK); ClinicalTrials.gov number, NCT05466825.)
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Cardiology
- Cardiology General
- Coronary Disease/Myocardial Infarction
- Diabetes
- Endocrinology
- Hypertension
- Lipids
- Obesity
- Prevention
- Public Health
- Public Health General
- Cardiovascular Diseases
- Cohort Studies
- Diabetes Mellitus
- Female
- Humans
- Male
- Middle Aged
- Risk Factors
- Smoking
- high density lipoprotein cholesterol
- adult
- all cause mortality
- Article
- body mass
- cardiovascular disease
- cardiovascular mortality
- cohort analysis
- confidence interval
- controlled study
- current smoker
- death
- diabetes mellitus
- female
- follow up
- groups by age and sex
- human
- incidence
- major clinical study
- male
- middle aged
- prevalence
- proportional hazards model
- risk factor
- systolic blood pressure
- treatment outcome
- smoking
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Magnussen, Chris ...
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Melander, O.
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Leong, Darryl P.
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Alegre-Diaz, Jes ...
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Amouyel, Philipp ...
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Aviles-Santa, La ...
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De Bacquer, Dirk
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Ballantyne, Chri ...
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Bernabé-Ortiz, A ...
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Bobak, Martin
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Brenner, Hermann
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Carrillo-Larco, ...
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De Lemos, James
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Dobson, Annette
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Dörr, Marcus
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Donfrancesco, Ch ...
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Drygas, Wojciech
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Dullaart, Robin ...
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Engström, G.
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Ferrario, Marco ...
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Ferrières, Jean
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De Gaetano, Giov ...
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Goldbourt, Uri
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Gonzalez, Clicer ...
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Grassi, Guido
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Hodge, Allison M ...
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Hveem, Kristian
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Iacoviello, Lici ...
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Ikram, M. Kamran
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Irazola, Vilma
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Jobe, Modou
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Jousilahti, Pekk ...
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Kaleebu, Pontian ...
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Kavousi, Maryam
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Kee, Frank
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Khalili, Davood
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Koenig, Wolfgang
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Kontsevaya, Anna
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Kuulasmaa, Kari
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Lackner, Karl J.
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Leistner, David ...
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Lind, Lars
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Linneberg, Allan
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Lorenz, Thiess
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Lyngbakken, Magn ...
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Malekzadeh, Reza
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Malyutina, Sofia
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Mathiesen, Ellis ...
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Melander, Olle
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Metspalu, Andres
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Miranda, J. Jaim ...
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Moitry, Marie
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Mugisha, Joseph
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Nalini, Mahdi
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Nambi, Vijay
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Ninomiya, Toshih ...
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Oppermann, Karen
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D'Orsi, Eleonora
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Pająk, Andrzej
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Palmieri, Luigi
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Panagiotakos, De ...
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Perianayagam, Ar ...
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Peters, Annette
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Poustchi, Hossei ...
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Prentice, Andrew ...
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Prescott, Eva
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Risérus, Ulf
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Salomaa, Veikko
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Sans, Susana
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Sakata, Satoko
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Schöttker, Ben
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Schutte, Aletta ...
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Sepanlou, Sadaf ...
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Sharma, Sanjib K ...
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Shaw, Jonathan E ...
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Simons, Leon A.
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Söderberg, Stefa ...
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Tamosiunas, Abdo ...
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Thorand, Barbara
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Tunstall-Pedoe, ...
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Twerenbold, Raph ...
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Vanuzzo, Diego
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Veronesi, Giovan ...
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Waibel, Julia
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Wannamethee, S. ...
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Watanabe, Masafu ...
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Wild, Philipp S.
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Yao, Yao
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Zeng, Yi
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Ziegler, Andreas
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Blankenberg, Ste ...
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