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Ab initio phasing o...
Ab initio phasing of the diffraction of crystals with translational disorder
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- Morgan, Andrew J. (författare)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany;Univ Melbourne, Sch Phys, ARC Ctr Excellence Adv Mol Imaging Sch Phys, Parkville, Vic 3010, Australia
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- Ayyer, Kartik (författare)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany;Max Planck Inst Struct & Dynam Matter, Luruper Chaussee 149, D-22761 Hamburg, Germany;Ctr Free Electron Laser Sci, Luruper Chaussee 149, D-22761 Hamburg, Germany
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- Barty, Anton (författare)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany
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- Chen, Joe P. J. (författare)
- Arizona State Univ, Dept Phys, Tempe, AZ 85287 USA
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- Ekeberg, Tomas, 1983- (författare)
- Uppsala universitet,Molekylär biofysik,Deutsch Elektronen Synchrotron DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany
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- Oberthuer, Dominik (författare)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany
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- White, Thomas A. (författare)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany
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- Yefanov, Oleksandr (författare)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany
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- Chapman, Henry N. (författare)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Electron Laser Sci, Notkestr 85, D-22607 Hamburg, Germany;Univ Hamburg, Dept Phys, Luruper Chaussee 149, D-22761 Hamburg, Germany;Ctr Ultrafast Imaging, Luruper Chaussee 149, D-22761 Hamburg, Germany
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(creator_code:org_t)
- INT UNION CRYSTALLOGRAPHY, 2019
- 2019
- Engelska.
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Ingår i: Acta Crystallographica Section A. - : INT UNION CRYSTALLOGRAPHY. - 2053-2733. ; 75, s. 25-40
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- To date X-ray protein crystallography is the most successful technique available for the determination of high-resolution 3D structures of biological molecules and their complexes. In X-ray protein crystallography the structure of a protein is refined against the set of observed Bragg reflections from a protein crystal. The resolution of the refined protein structure is limited by the highest angle at which Bragg reflections can be observed. In addition, the Bragg reflections alone are typically insufficient (by a factor of two) to determine the structure ab initio, and so prior information is required. Crystals formed from an imperfect packing of the protein molecules may also exhibit continuous diffraction between and beyond these Bragg reflections. When this is due to random displacements of the molecules from each crystal lattice site, the continuous diffraction provides the necessary information to determine the protein structure without prior knowledge, to a resolution that is not limited by the angular extent of the observed Bragg reflections but instead by that of the diffraction as a whole. This article presents an iterative projection algorithm that simultaneously uses the continuous diffraction as well as the Bragg reflections for the determination of protein structures. The viability of this method is demonstrated on simulated crystal diffraction.
Ämnesord
- NATURVETENSKAP -- Biologi -- Strukturbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Structural Biology (hsv//eng)
Nyckelord
- X-ray diffraction
- diffuse scattering
- phase retrieval
- macromolecular crystallography
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Morgan, Andrew J ...
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Ayyer, Kartik
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Barty, Anton
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Chen, Joe P. J.
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Ekeberg, Tomas, ...
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Oberthuer, Domin ...
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visa fler...
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White, Thomas A.
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Yefanov, Oleksan ...
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Chapman, Henry N ...
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Strukturbiologi
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Acta Crystallogr ...
- Av lärosätet
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Uppsala universitet