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Clinical characteri...
Clinical characteristics and phylogenetic analysis of human enteric adenovirus type 41 (HAdV-F41) from children with gastroenteritis during SARS-CoV-2 pandemic
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- Bai, Ru (författare)
- Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, China; The Guangdong Second Provincial General Hospital, Guangzhou, China
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- Chen, Yanyuan (författare)
- Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, China
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- Ou, Junxian (författare)
- Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Institute of Medical Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China
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- Dong, Wenya (författare)
- Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, China
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- Zhong, Tianhua (författare)
- Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, China
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- Li, Yiqiang (författare)
- Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Institute of Medical Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China
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- Li, Congrong (författare)
- Biosafety Laboratory, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
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- Liu, Chengyi (författare)
- Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, China
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- Ji, Cunwei (författare)
- Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, China
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- Li, Huan (författare)
- Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, China
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- Luo, Yasha (författare)
- Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, China
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- Mei, Ya-Fang (författare)
- Umeå universitet,Avdelningen för virologi
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- Wu, Jie (författare)
- Guangdong Center for Disease Control and Prevention, Guangzhou, China
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- Seto, Donald (författare)
- Bioinformatics and Computational Biology Program, School of Systems Biology, George Mason University, VA, Manassas, United States
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- Yin, Aihua (författare)
- Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, China; Medical Genetic Center, Guangdong Women and Children Hospital, Guangzhou, China
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- Zhang, Qiwei (författare)
- Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Institute of Medical Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China
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- Luo, Mingyong (författare)
- Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, China
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(creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
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Ingår i: Infection, Genetics and Evolution. - : Elsevier. - 1567-1348 .- 1567-7257. ; 123
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Human adenovirus type 41 (HAdV-F41) usually causes pediatrics gastroenteritis. However, it was reported to be associated with the outbreaks of severe acute hepatitis of unknown aetiology (SAHUA) in pediatrics during COVID-19 pandemic. In this study, we investigated the prevalence of enteric HAdV-F41 in 37,920 paediatric gastroenteritis cases from 2017 to 2022 in Guangzhou, China. All children presented were tested negative for SARS-CoV-2 during the “zero-COVID” period. The main clinical symptom of the children was diarrhea (96.5%). No fatalities nor liver abnormal symptoms was found. In 2021, one year since the pandemic of COVID-19, the prevalence of HAdV-F41 abruptly increased from 3.71% to 8.64% (P < 0.001). All of HAdV-F41 circulating worldwide were classified into eight different subtypes (G1-G8) based on the phylogenetic clustering permutation of the four capsid genes of HAdV-F41. G3 was the predominant subtype (56.2%; 77/137). CRV5 isolates from SAHUA cases belong to this subtype, in which N312D and H335D mutations in the short fiber knob were identified in both Guangzhou and CRV5 isolates, presumably changing the virus tropism by directly interacting with the heparin sulfate (HS) receptor. Additionally, a novel recombinant G6 subtype, which is unique and only circulating in China was first identified in this study. This is the first study highlighting the prevalence of HAdV-F41 in paediatric cases of gastroenteritis during COVID-19 pandemic in China. The clinical and viral evolution finding of HAdV-F41 provide insight into the clinical characteristics of children with HAdV-F41 infections as well as the uncertain role of HAdV-F41 in the cause of SAHUA.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Clinical characteristics
- Evolution
- Genome
- HAdV-F41
- Recombination
- Severe acute hepatitis of unknown aetiology (SAHUA)
- Subtype
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Bai, Ru
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Chen, Yanyuan
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Ou, Junxian
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Dong, Wenya
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Zhong, Tianhua
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Li, Yiqiang
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visa fler...
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Li, Congrong
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Liu, Chengyi
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Ji, Cunwei
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Li, Huan
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Luo, Yasha
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Mei, Ya-Fang
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Wu, Jie
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Seto, Donald
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Yin, Aihua
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Zhang, Qiwei
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Luo, Mingyong
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visa färre...
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Umeå universitet