Immunological findings in blood and bronchoalveolar lavage fluid in chronic bronchitis patients with recurrent infectious exacerbations

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Bengtsson Ingemar) > (1990-1999) > Immunological findi...

4 of 4
Previous record
Next record
To hitlist

Immunological findings in blood and bronchoalveolar lavage fluid in chronic bronchitis patients with recurrent infectious exacerbations

Qvarfordt, Ingemar, 1954 (author): Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine

Riise, Gerdt C., 1956 (author): Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine

Larsson, Sven, 1943 (author): Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine

Almqvist, G. (author)

Rollof, J. (author)

Bengtsson, T. (author)

Andersson, Bengt A., 1952 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicinsk mikrobiologi och immunologi,Institute of Medical Microbiology/Immunology

show less...

(creator_code:org_t)

1998
1998
English.
In: Eur Respir J. - 0903-1936. ; 11:1, s. 46-54

Related links:: https://gup.ub.gu.se...

Journal article (peer-reviewed)

Abstract Subject headings

Bronchial infections are common in smokers and seem to be related to the presence of chronic bronchitis (CB). Why only some smokers develop repeated bronchial infections is not known. The aim of this study was to screen for immunological changes associated with disease in patients with CB and recurrent infectious exacerbations compared to asymptomatic smokers. Sixteen smokers with stable CB and recurrent infectious exacerbations, and 18 asymptomatic smokers, all without any immunomodulating treatment, underwent bronchoscopy and bronchoalveolar lavage (BAL). Smoking history and current smoking status were comparable. Serum levels of immunoglobulin (Ig)A, IgM, IgG and IgG subclasses were measured. Blood and BAL lymphocyte phenotypes and proliferative responses of peripheral blood mononuclear cells (PBMCs) to various stimulators were analysed. Unstimulated and tetanus toxoid-stimulated production of cytokines in PBMC cultures was measured. Natural killer (NK-) cell activity was analysed. A significantly (p<0.05) lower level of IgG3 was found in the CB group, and a significantly (p<0.01) higher proliferative response of PBMCs was found in the CB group after stimulation with diphtheria toxoid. Detectable levels of interleukin (IL)-6, tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma, but not of IL-2, IL-4 or transforming growth factor-beta2, were found in supernatants from cultured cells in both study groups. Stimulated TNF-alpha production was significantly (p<0.05) higher in the CB group. NK-cell activity did not differ significantly between the study groups. There were no major differences between the groups in lymphocyte subpopulations in blood or BAL. In conclusion, no major alterations in the analysed indices of cell-mediated and humoral immunity were found in patients with chronic bronchitis prone to recurrent infectious exacerbations when compared with asymptomatic smoking controls.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

Keyword

Adult
Blood/*immunology
Blood Cells/pathology
Bronchitis/*complications/*immunology
Bronchoalveolar Lavage Fluid/cytology/*immunology
Cell Division/physiology
Chronic Disease
Cross-Sectional Studies
Cytokines/biosynthesis
Female
Flow Cytometry
Humans
Immunoglobulins/analysis
Infection/*complications
Lymphocyte Subsets/pathology
Lymphocytes/pathology
Male
Middle Aged
Recurrence
Smoking

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

Eur Respir J (Search for host publication in LIBRIS)

To the university's database

4 of 4
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Qvarfordt, Ingem ...; Riise, Gerdt C., ...; Larsson, Sven, 1 ...; Almqvist, G.; Rollof, J.; Bengtsson, T.; show more...; Andersson, Bengt ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dermatology and ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Microbiology in ...

Articles in the publication: Eur Respir J

By the university: University of Gothenburg

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se