WFRF:(Brunet J. M.)
Sökning: WFRF:(Brunet J. M.) > (1995-1999) > Pregnancy and risk ...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03617naa a2200409 4500 | |
| 001 | oai:lup.lub.lu.se:a57c2e1a-c8f1-4551-b3dd-c1a92e34aeac | |
| 003 | SwePub | |
| 008 | 160401s1999 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/11146392 URI |
| 024 | 7 | a https://doi.org/10.1016/S0140-6736(99)04336-62 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Jernström, Helenau Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-hje |
| 245 | 1 0 | a Pregnancy and risk of early breast cancer in carriers of BRCA1 and BRCA2 |
| 264 | 1 | c 1999 |
| 520 | a BACKGROUND: Early age at first full-term pregnancy and increasing parity are associated with a reduced risk of breast cancer. However, whether pregnancy decreases the risk of early-onset hereditary breast cancer is unknown. There is concern that pregnancy may increase breast-cancer risk in carriers of BRCA1 and BRCA2 germline mutations. We aimed to establish whether pregnancy is a risk factor for hereditary breast cancer. METHODS: We did a matched case-control study of breast cancer in women who carry deleterious BRCA1 or BRCA2 mutations. Cases were carriers who developed breast cancer by age 40 years, and controls were carriers of the same age without breast cancer, or who were diagnosed with breast cancer after age 40 years. Women who had undergone preventive mastectomy, hysterectomy, or oophorectomy, or who were diagnosed with ovarian cancer before the age at which breast cancer was diagnosed in the matched case were excluded. Information about pregnancies and pregnancy outcome was derived from a questionnaire completed by women in the course of genetic counselling. FINDINGS: A higher proportion of cases than controls had had a full term pregnancy (173/236 vs 146/236; odds ratio 1.71 [95% CI 1.13-2.62], p=0.01). The mean number of births was also greater for cases than for controls (1.62 vs 1.38, p=0.04). The risk increased with the number of births and did not diminish with time since last pregnancy. There were no significant differences in age at first birth or age at last birth between cases and controls. INTERPRETATION: Carriers of the BRCA1 and BRCA2 mutations who have children are significantly more likely to develop breast cancer by age 40 than carriers who are nulliparous. Each pregnancy is associated with an increased cancer risk. An early first pregnancy does not confer protection for carriers of BRCA1 or BRCA2 mutations. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 700 | 1 | a Lerman, C4 aut |
| 700 | 1 | a Ghadirian, P4 aut |
| 700 | 1 | a Lynch, H T4 aut |
| 700 | 1 | a Weber, B4 aut |
| 700 | 1 | a Garber, J4 aut |
| 700 | 1 | a Daly, M4 aut |
| 700 | 1 | a Olopade, O I4 aut |
| 700 | 1 | a Foulkes, W D4 aut |
| 700 | 1 | a Warner, E4 aut |
| 700 | 1 | a Brunet, J S4 aut |
| 700 | 1 | a Narod, S A4 aut |
| 710 | 2 | a Bröstcancer-genetikb Sektion I4 org |
| 773 | 0 | t The Lancetg 354:9193, s. 1846-1850q 354:9193<1846-1850x 1474-547X |
| 856 | 4 | u http://dx.doi.org/10.1016/S0140-6736(99)04336-6y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1114639 |
| 856 | 4 8 | u https://doi.org/10.1016/S0140-6736(99)04336-6 |
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- Daly, M
- Olopade, O I
- Foulkes, W D
- Warner, E
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