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Sökning: WFRF:(Bushnell C) > (2010-2014) > Altered C-tactile p...

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FältnamnIndikatorerMetadata
00005730naa a2200589 4500
001oai:gup.ub.gu.se/175440
003SwePub
008240528s2013 | |||||||||||000 ||eng|
009oai:DiVA.org:liu-126209
0247 a https://gup.ub.gu.se/publication/1754402 URI
0247 a https://doi.org/10.1016/j.pain.2012.10.0242 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1262092 URI
040 a (SwePub)gud (SwePub)liu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Liljencrantz, Jaquetteu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:gu)xlijaq
2451 0a Altered C-tactile processing in human dynamic tactile allodynia
264 1b Ovid Technologies (Wolters Kluwer Health),c 2013
520 a Human unmyelinated (C) tactile afferents signal the pleasantness of gentle skin stroking on hairy (nonglabrous) skin. After neuronal injury, that same type of touch can elicit unpleasant sensations: tactile allodynia. The prevailing pathophysiological explanation is a spinal cord sensitization, triggered by nerve injury, which enables Aβ afferents to access pain pathways. However, a recent mouse knockout study demonstrates that C-tactile afferents are necessary for allodynia to develop, suggesting a role for not only Aβ but also C-tactile afferent signaling. To examine the contribution of C-tactile afferents to the allodynic condition in humans, we applied the heat/capsaicin model of tactile allodynia in 43 healthy subjects and in 2 sensory neuronopathy patients lacking Aβ afferents. Healthy subjects reported tactile-evoked pain, whereas the patients did not. Instead, patients reported their C-touch percept (faint sensation of pleasant touch) to be significantly weaker in the allodynic zone compared to untreated skin. Functional magnetic resonance imaging in 18 healthy subjects and in 1 scanned patient indicated that stroking in the allodynic and control zones evoked different responses in the primary cortical receiving area for thin fiber signaling, the posterior insular cortex. In addition, reduced activation in the medial prefrontal cortices, key areas for C-tactile hedonic processing, was identified. These findings suggest that dynamic tactile allodynia is associated with reduced C-tactile mediated hedonic touch processing. Nevertheless, because the patients did not develop allodynic pain, this seems dependent on Aβ signaling, at least under these experimental conditions.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653 a C-tactile afferents
653 a Functional magnetic resonance imaging
653 a Neuropathic pain
653 a Psychophysics
653 a Tactile
653 a human hairy skin
653 a posterior insular cortex
653 a bold-contrast sensitivity
653 a rat spinal-cord
653 a secondary hyperalgesia
653 a myelinated afferents
653 a neuropathic pain
653 a unmyelinated afferents
653 a sensory neuronopathy
653 a mechanical allodynia
653 a C-tactile afferents
7001 a Björnsdotter, Malinu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:liu)malab53
7001 a Morrison, India,d 1972u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:gu)xmorin
7001 a Bergstrand, Simonu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden4 aut
7001 a Ceko, M.u Alan Edwards Centre for Research on Pain, McGill University, Montreal, Canada4 aut
7001 a Seminowicz, D. A.u Alan Edwards Centre for Research on Pain, McGill University, Montreal, Canada4 aut
7001 a Cole, J.u Department of Clinical Neurophysiology, Poole Hospital and University of Bournemouth, Bournemouth, UK4 aut
7001 a Bushnell, M. C.u Alan Edwards Centre for Research on Pain, McGill University, Montreal, Canada4 aut
7001 a Olausson, Håkan,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden; Department of Integrative Physiology, School of Medicine, University of Western Sydney, Sydney, Australia4 aut0 (Swepub:gu)xolaha
7102 a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi4 org
7730 t Paind : Ovid Technologies (Wolters Kluwer Health)g 154:2, s. 227-234q 154:2<227-234x 0304-3959x 1872-6623
8564 8u https://gup.ub.gu.se/publication/175440
8564 8u https://doi.org/10.1016/j.pain.2012.10.024
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-126209

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