Sökning: WFRF:(Byers Robert M.) >
Clinical insights i...
Clinical insights into small cell lung cancer : Tumor heterogeneity, diagnosis, therapy, and future directions
-
- Megyesfalvi, Zsolt (författare)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Medical University of Vienna,National Institute of Oncology, Budapest
-
- Gay, Carl M. (författare)
- University of Texas
-
- Popper, Helmut (författare)
- Medical University of Graz
-
visa fler...
-
- Pirker, Robert (författare)
- Medical University of Vienna
-
- Ostoros, Gyula (författare)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary
-
- Heeke, Simon (författare)
- University of Texas
-
- Lang, Christian (författare)
- Medical University of Vienna
-
- Hoetzenecker, Konrad (författare)
- Medical University of Vienna
-
- Schwendenwein, Anna (författare)
- Medical University of Vienna
-
- Boettiger, Kristiina (författare)
- Medical University of Vienna
-
- Bunn, Paul A. (författare)
- University of Colorado School of Medicine
-
- Renyi-Vamos, Ferenc (författare)
- National Institute of Oncology, Budapest,National Korányi Institute for Tuberculosis and Pulmonology, Hungary
-
- Schelch, Karin (författare)
- Medical University of Vienna
-
- Prosch, Helmut (författare)
- Vienna General Hospital / University Hospital Vienna
-
- Byers, Lauren A. (författare)
- University of Texas
-
- Hirsch, Fred R. (författare)
- University of Colorado,Icahn School of Medicine at Mount Sinai
-
- Dome, Balazs (författare)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,Semmelweis University,National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Medical University of Vienna
-
visa färre...
-
(creator_code:org_t)
- 2023
- 2023
- Engelska.
-
Ingår i: CA: a cancer journal for clinicians. - 0007-9235. ; 73:6, s. 620-652
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- Small cell lung cancer (SCLC) is characterized by rapid growth and high metastatic capacity. It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority of SCLCs exhibit neuroendocrine features, an important subset of tumors lacks these properties. Genomic profiling of SCLC reveals genetic instability, almost universal inactivation of the tumor suppressor genes TP53 and RB1, and a high mutation burden. Because of early metastasis, only a small fraction of patients are amenable to curative-intent lung resection, and these individuals require adjuvant platinum-etoposide chemotherapy. Therefore, the vast majority of patients are currently being treated with chemoradiation with or without immunotherapy. In patients with disease confined to the chest, standard therapy includes thoracic radiotherapy and concurrent platinum-etoposide chemotherapy. Patients with metastatic (extensive-stage) disease are treated with a combination of platinum-etoposide chemotherapy plus immunotherapy with an anti-programmed death-ligand 1 monoclonal antibody. Although SCLC is initially very responsive to platinum-based chemotherapy, these responses are transient because of the development of drug resistance. In recent years, the authors have witnessed an accelerating pace of biologic insights into the disease, leading to the redefinition of the SCLC classification scheme. This emerging knowledge of SCLC molecular subtypes has the potential to define unique therapeutic vulnerabilities. Synthesizing these new discoveries with the current knowledge of SCLC biology and clinical management may lead to unprecedented advances in SCLC patient care. Here, the authors present an overview of multimodal clinical approaches in SCLC, with a special focus on illuminating how recent advancements in SCLC research could accelerate clinical development.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- chemotherapy
- diagnosis
- immunotherapy
- molecular subtypes
- small cell lung cancer
Publikations- och innehållstyp
- for (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Megyesfalvi, Zso ...
-
Gay, Carl M.
-
Popper, Helmut
-
Pirker, Robert
-
Ostoros, Gyula
-
Heeke, Simon
-
visa fler...
-
Lang, Christian
-
Hoetzenecker, Ko ...
-
Schwendenwein, A ...
-
Boettiger, Krist ...
-
Bunn, Paul A.
-
Renyi-Vamos, Fer ...
-
Schelch, Karin
-
Prosch, Helmut
-
Byers, Lauren A.
-
Hirsch, Fred R.
-
Dome, Balazs
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
CA: a cancer jou ...
- Av lärosätet
-
Lunds universitet