WFRF:(Cao Yun)
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LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05015naa a2200553 4500 | |
| 001 | oai:DiVA.org:liu-101394 | |
| 003 | SwePub | |
| 008 | 131121s2013 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:127623600 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1013942 URI |
| 024 | 7 | a https://doi.org/10.1016/j.cmet.2013.06.0032 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1276236002 URI |
| 040 | a (SwePub)liud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Dong, Meiu Shandong University, Peoples R China4 aut |
| 245 | 1 0 | a Cold Exposure Promotes Atherosclerotic Plaque Growth and Instability via UCP1-Dependent Lipolysis |
| 264 | 1 | b Elsevier (Cell Press),c 2013 |
| 338 | a electronic2 rdacarrier | |
| 500 | a Funding Agencies|Swedish Research Council||Swedish Cancer Foundation||Karolinska Institute Foundation||Karolinska Institute Distinguished Professor Award||Torsten Soderbergs Foundation||Tianjin Natural Science Foundation (CMM-Tianjin)|09ZCZDSF04400|ImClone Systems of Eli Lilly||European Union Integrated Project of Metoxia|222741|European Research Council (ERC) advanced grant ANGIOFAT|250021|National 973 Basic Research Program of China|2011CB5039062012CB518603|National High-Tech Research and Development Program of China|2012AA02A510|Program of Introducing Talents of Discipline to Universities|B07035|State Program of National Natural Science Foundation of China for Innovative Research Group|81021001|National Natural Science Foundation of China|811002078117325181100102812703508100012681000127| | |
| 520 | a Molecular mechanisms underlying the cold-associated high cardiovascular risk remain unknown. Here, we show that the cold-triggered food-intake-independent lipolysis significantly increased plasma levels of small low-density lipoprotein (LDL) remnants, leading to accelerated development of atherosclerotic lesions in mice. In two genetic mouse knockout models (apolipoprotein E-/- [ApoE(-/-)] and LDL receptor(-/-) [Ldlr(-/-)] mice), persistent cold exposure stimulated atherosclerotic plaque growth by increasing lipid deposition. Furthermore, marked increase of inflammatory cells and plaque-associated microvessels were detected in the cold-acclimated ApoE(-/-) and Ldlr(-/-) mice, leading to plaque instability. Deletion of uncoupling protein 1 (UCP1), a key mitochondrial protein involved in thermogenesis in brown adipose tissue (BAT), in the ApoE(-/-) strain completely protected mice from the cold-induced atherosclerotic lesions. Cold acclimation markedly reduced plasma levels of adiponectin, and systemic delivery of adiponectin protected ApoE(-/-) mice from plaque development. These findings provide mechanistic insights on low-temperature-associated cardiovascular risks. | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Yang, Xiaoyanu Shandong University, Peoples R China4 aut |
| 700 | 1 | a Lim, Sharonu Karolinska Institutet4 aut |
| 700 | 1 | a Cao, Ziquanu Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet4 aut0 (Swepub:liu)ziqca08 |
| 700 | 1 | a Honek, Jenniferu Karolinska Institutet4 aut |
| 700 | 1 | a Lu, Huixiau Shandong University, Peoples R China4 aut |
| 700 | 1 | a Zhang, Chengu Shandong University, Peoples R China4 aut |
| 700 | 1 | a Seki, Takahirou Karolinska Institutet4 aut |
| 700 | 1 | a Hosaka, Kayokou Karolinska Institutet4 aut |
| 700 | 1 | a Wahlberg, Ericu Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Thorax-kärlkliniken i Östergötland4 aut0 (Swepub:liu)eriwa73 |
| 700 | 1 | a Yang, Jianminu Shandong University, Peoples R China4 aut |
| 700 | 1 | a Zhang, Leiu Shandong University, Peoples R China4 aut |
| 700 | 1 | a Länne, Tosteu Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Thorax-kärlkliniken i Östergötland4 aut0 (Swepub:liu)tosla34 |
| 700 | 1 | a Sun, Baocunu Tianjin Medical University, Peoples R China4 aut |
| 700 | 1 | a Li, Xuriu Sun Yat Sen University, Peoples R China4 aut |
| 700 | 1 | a Liu, Yizhiu Sun Yat Sen University, Peoples R China4 aut |
| 700 | 1 | a Zhang, Yunu Shandong University, Peoples R China4 aut |
| 700 | 1 | a Cao, Yihaiu Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutetb Shandong University, Peoples R China4 org |
| 773 | 0 | t Cell Metabolismd : Elsevier (Cell Press)g 18:1, s. 118-129q 18:1<118-129x 1550-4131x 1932-7420 |
| 856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:666295/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u http://www.cell.com/article/S1550413113002477/pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-101394 |
| 856 | 4 8 | u https://doi.org/10.1016/j.cmet.2013.06.003 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:127623600 |
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- Dong, Mei
- Yang, Xiaoyan
- Lim, Sharon
- Cao, Ziquan
- Honek, Jennifer
- Lu, Huixia
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- Zhang, Cheng
- Seki, Takahiro
- Hosaka, Kayoko
- Wahlberg, Eric
- Yang, Jianmin
- Zhang, Lei
- Länne, Toste
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- Li, Xuri
- Liu, Yizhi
- Zhang, Yun
- Cao, Yihai
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