WFRF:(Carbonnel M.)
Sökning: WFRF:(Carbonnel M.) > Circulating plasma ...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05254naa a2200877 4500 | |
| 001 | oai:DiVA.org:umu-154947 | |
| 003 | SwePub | |
| 008 | 190107s2018 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:139626610 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1549472 URI |
| 024 | 7 | a https://doi.org/10.1002/ijc.317972 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1396266102 URI |
| 040 | a (SwePub)umud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Matejcic, M.4 aut |
| 245 | 1 0 | a Circulating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort |
| 264 | c 2018-09-21 | |
| 264 | 1 | b WILEY,c 2018 |
| 338 | a print2 rdacarrier | |
| 520 | a There are both limited and conflicting data on the role of dietary fat and specific fatty acids in the development of pancreatic cancer. In this study, we investigated the association between plasma phospholipid fatty acids and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The fatty acid composition was measured by gas chromatography in plasma samples collected at recruitment from375 incident pancreatic cancer cases and375 matched controls. Associations of specific fatty acids with pancreatic cancer risk were evaluated using multivariable conditional logistic regression models with adjustment for established pancreatic cancer risk factors. Statistically significant inverse associations were found between pancreatic cancer incidence and levels of heptadecanoic acid (ORT3‐T1[odds ratio for highest versus lowest tertile] =0.63; 95%CI[confidence interval] = 0.41–0.98; ptrend = 0.036), n‐3 polyunsaturated α‐linolenic acid (ORT3‐T1 = 0.60; 95%CI = 0.39–0.92; ptrend = 0.02) and docosapentaenoic acid (ORT3‐T1 = 0.52; 95%CI = 0.32–0.85; ptrend = 0.008). Industrial trans‐fatty acids were positively associated with pancreatic cancer risk among men (ORT3‐T1 = 3.00; 95%CI = 1.13–7.99; ptrend = 0.029), while conjugated linoleic acids were inversely related to pancreatic cancer among women only (ORT3‐T1 = 0.37; 95%CI = 0.17–0.81; ptrend = 0.008). Among current smokers, the long‐chain n‐6/n‐3 polyunsaturated fatty acids ratio was positively associated with pancreatic cancer risk (ORT3‐T1 = 3.40; 95%CI = 1.39–8.34; ptrend = 0.007). Results were robust to a range of sensitivity analyses. Our findings suggest that higher circulating levels of saturated fatty acids with an odd number of carbon atoms and n‐3 polyunsaturated fatty acids may be related to lower risk of pancreatic cancer. The influence of some fatty acids on the development of pancreatic cancer may be sex‐specific and modulated by smoking. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a biomarkers | |
| 653 | a plasma phospholipids | |
| 653 | a fatty acids | |
| 653 | a tobacco smoking | |
| 653 | a pancreatic cancer | |
| 700 | 1 | a Lesueur, F.4 aut |
| 700 | 1 | a Biessy, C.4 aut |
| 700 | 1 | a Renault, A. L.4 aut |
| 700 | 1 | a Mebirouk, N.4 aut |
| 700 | 1 | a Yammine, S.4 aut |
| 700 | 1 | a Keski-Rahkonen, P.4 aut |
| 700 | 1 | a Li, K.4 aut |
| 700 | 1 | a Hemon, B.4 aut |
| 700 | 1 | a Weiderpass, E.u Karolinska Institutet4 aut |
| 700 | 1 | a Rebours, V.4 aut |
| 700 | 1 | a Boutron-Ruault, M. C.4 aut |
| 700 | 1 | a Carbonnel, F.4 aut |
| 700 | 1 | a Kaaks, R.4 aut |
| 700 | 1 | a Katzke, V.4 aut |
| 700 | 1 | a Kuhn, T.4 aut |
| 700 | 1 | a Boeing, H.4 aut |
| 700 | 1 | a Trichopoulou, A.4 aut |
| 700 | 1 | a Palli, D.4 aut |
| 700 | 1 | a Agnoli, C.4 aut |
| 700 | 1 | a Panico, S.4 aut |
| 700 | 1 | a Tumino, R.4 aut |
| 700 | 1 | a Sacerdote, C.4 aut |
| 700 | 1 | a Quiros, J. R.4 aut |
| 700 | 1 | a Duell, E. J.4 aut |
| 700 | 1 | a Porta, M.4 aut |
| 700 | 1 | a Sanchez, M. J.4 aut |
| 700 | 1 | a Chirlaque, M. D.4 aut |
| 700 | 1 | a Barricarte, A.4 aut |
| 700 | 1 | a Amiano, P.4 aut |
| 700 | 1 | a Ye, Weiminu Karolinska Institutet,Umeå universitet,Enheten för biobanksforskning,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden4 aut |
| 700 | 1 | a Peeters, P. H.4 aut |
| 700 | 1 | a Khaw, K. T.4 aut |
| 700 | 1 | a Perez-Cornago, A.4 aut |
| 700 | 1 | a Key, T. J.4 aut |
| 700 | 1 | a Bueno-de-Mesquita, H. B.4 aut |
| 700 | 1 | a Riboli, E.4 aut |
| 700 | 1 | a Vineis, P.4 aut |
| 700 | 1 | a Romieu, I.4 aut |
| 700 | 1 | a Gunter, M. J.4 aut |
| 700 | 1 | a Chajes, V.4 aut |
| 710 | 2 | a Karolinska Institutetb Enheten för biobanksforskning4 org |
| 773 | 0 | t International Journal of Cancerd : WILEYg 143:10, s. 2437-2448q 143:10<2437-2448x 0020-7136x 1097-0215 |
| 856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.31797 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-154947 |
| 856 | 4 8 | u https://doi.org/10.1002/ijc.31797 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:139626610 |
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- Matejcic, M.
- Lesueur, F.
- Biessy, C.
- Renault, A. L.
- Mebirouk, N.
- Yammine, S.
- visa fler...
- Keski-Rahkonen, ...
- Li, K.
- Hemon, B.
- Weiderpass, E.
- Rebours, V.
- Boutron-Ruault, ...
- Carbonnel, F.
- Kaaks, R.
- Katzke, V.
- Kuhn, T.
- Boeing, H.
- Trichopoulou, A.
- Palli, D.
- Agnoli, C.
- Panico, S.
- Tumino, R.
- Sacerdote, C.
- Quiros, J. R.
- Duell, E. J.
- Porta, M.
- Sanchez, M. J.
- Chirlaque, M. D.
- Barricarte, A.
- Amiano, P.
- Ye, Weimin
- Peeters, P. H.
- Khaw, K. T.
- Perez-Cornago, A ...
- Key, T. J.
- Bueno-de-Mesquit ...
- Riboli, E.
- Vineis, P.
- Romieu, I.
- Gunter, M. J.
- Chajes, V.
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