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Genome-wide associa...
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
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Saxena, Richa (author)
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Voight, Benjamin F. (author)
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- Lyssenko, Valeriya (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Burtt, Noel P. (author)
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de Bakker, Paul I. W. (author)
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Chen, Hong (author)
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Roix, Jeffrey J. (author)
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Kathiresan, Sekar (author)
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Hirschhorn, Joel N. (author)
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Daly, Mark J. (author)
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Hughes, Thomas E. (author)
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Altshuler, David (author)
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- Almgren, Peter (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Florez, Jose C. (author)
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Meyer, Joanne (author)
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Ardlie, Kristin (author)
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- Bengtsson Boström, Kristina (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Isomaa, Bo (author)
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Lettre, Guillaume (author)
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- Lindblad, Ulf (author)
- Lund University,Lunds universitet,Samhällsmedicin,Forskargrupper vid Lunds universitet,Community Medicine,Lund University Research Groups
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Lyon, Helen N. (author)
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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Newton-Cheh, Christopher (author)
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- Nilsson, Peter (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Orho-Melander, Marju (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Råstam, Lennart (author)
- Lund University,Lunds universitet,Samhällsmedicin,Forskargrupper vid Lunds universitet,Community Medicine,Lund University Research Groups
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Speliotes, Elizabeth K. (author)
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Taskinen, Marja-Riitta (author)
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Tuomi, Tiinamaija (author)
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Guiducci, Candace (author)
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- Berglund, Anna (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Carlson, Joyce (author)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups
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Gianniny, Lauren (author)
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Hackett, Rachel (author)
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Hall, Liselotte (author)
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- Holmkvist, Johan (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Laurila, Esa (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Sjögren, Marketa (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - hypertoni,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Cardiovascular Research - Hypertension
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Sterner, Maria (author)
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Surti, Aarti (author)
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- Svensson, Margareta (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Svensson, Malin (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Tewhey, Ryan (author)
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Blumenstiel, Brendan (author)
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Parkin, Melissa (author)
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DeFelice, Matthew (author)
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Barry, Rachel (author)
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Brodeur, Wendy (author)
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Camarata, Jody (author)
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Chia, Nancy (author)
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Fava, Mary (author)
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Gibbons, John (author)
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Handsaker, Bob (author)
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Healy, Claire (author)
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Nguyen, Kieu (author)
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Gates, Casey (author)
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Sougnez, Carrie (author)
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Gage, Diane (author)
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Nizzari, Marcia (author)
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Gabriel, Stacey B. (author)
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Chirn, Gung-Wei (author)
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Ma, Qicheng (author)
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- Parikh, Hemang (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Richardson, Delwood (author)
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Ricke, Darrell (author)
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Purcell, Shaun (author)
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2007
- 2007
- English.
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In: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 316:5829, s. 1331-1336
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D - in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1 - and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study. We identified and confirmed association of a SNP in an intron of glucokinase regulatory protein (GCKR) with serum triglycerides. The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- By the author/editor
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Saxena, Richa
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Voight, Benjamin ...
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Lyssenko, Valeri ...
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Burtt, Noel P.
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de Bakker, Paul ...
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Chen, Hong
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show more...
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Roix, Jeffrey J.
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Kathiresan, Seka ...
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Hirschhorn, Joel ...
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Daly, Mark J.
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Hughes, Thomas E ...
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Groop, Leif
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Altshuler, David
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Almgren, Peter
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Florez, Jose C.
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Meyer, Joanne
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Ardlie, Kristin
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Bengtsson Boströ ...
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Isomaa, Bo
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Lettre, Guillaum ...
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Lindblad, Ulf
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Lyon, Helen N.
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Melander, Olle
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Newton-Cheh, Chr ...
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Nilsson, Peter
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Orho-Melander, M ...
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Råstam, Lennart
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Speliotes, Eliza ...
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Taskinen, Marja- ...
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Tuomi, Tiinamaij ...
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Guiducci, Candac ...
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Berglund, Anna
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Carlson, Joyce
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Gianniny, Lauren
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Hackett, Rachel
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Hall, Liselotte
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Holmkvist, Johan
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Laurila, Esa
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Sjögren, Marketa
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Sterner, Maria
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Surti, Aarti
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Svensson, Margar ...
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Svensson, Malin
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Tewhey, Ryan
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Blumenstiel, Bre ...
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Parkin, Melissa
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DeFelice, Matthe ...
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Barry, Rachel
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Brodeur, Wendy
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Camarata, Jody
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Chia, Nancy
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Fava, Mary
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Gibbons, John
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Handsaker, Bob
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Healy, Claire
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Nguyen, Kieu
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Gates, Casey
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Sougnez, Carrie
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Gage, Diane
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Nizzari, Marcia
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Gabriel, Stacey ...
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Chirn, Gung-Wei
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Ma, Qicheng
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Parikh, Hemang
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Richardson, Delw ...
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Ricke, Darrell
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Purcell, Shaun
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medicinal Chemis ...
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MEDICAL AND HEAL ...
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Lund University